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Invasive aspergillosis mimicking metastatic lung cancer

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Abstract
In a patient with a medical history of cancer, the most probable diagnosis of an (18)FDG-avid pulmonary mass combined with intracranial abnormalities on brain imaging is metastasized cancer. However, sometimes a differential diagnosis with an infectious cause such as aspergillosis can be very challenging as both cancer and infection are sometimes difficult to distinguish. Pulmonary aspergillosis can present as an infectious pseudotumour with clinical and imaging characteristics mimicking lung cancer. Even in the presence of cerebral lesions, radiological appearance of abscesses can look like brain metastasis. These similarities can cause significant diagnostic difficulties with a subsequent therapeutic delay and a potential adverse outcome. Awareness of this infectious disease that can mimic lung cancer, even in an immunocompetent patient, is important. We report a case of a 65-year-old woman with pulmonary aspergillosis disseminated to the brain mimicking metastatic lung cancer.
Keywords
PULMONARY ASPERGILLOSIS, COMPUTED-TOMOGRAPHY, BRAIN METASTASES, DIAGNOSIS, MRI, CT, lung cancer, lung neoplasms, brain metastasis, brain neoplasms, brain, abscess, aspergillosis, differential diagnosis

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Citation

Please use this url to cite or link to this publication:

MLA
Vanfleteren, Michiel et al. “Invasive Aspergillosis Mimicking Metastatic Lung Cancer.” FRONTIERS IN ONCOLOGY 8 (2018): n. pag. Print.
APA
Vanfleteren, M., Dingemans, A.-M. C., Surmont, V., Vermaelen, K., Postma, A. A., Oude lashof, A. M., Pitz, C. C., et al. (2018). Invasive aspergillosis mimicking metastatic lung cancer. FRONTIERS IN ONCOLOGY, 8.
Chicago author-date
Vanfleteren, Michiel, Anne-Marie C Dingemans, Veerle Surmont, Karim Vermaelen, Alida A Postma, Astrid ML Oude lashof, Cordula CM Pitz, and Lizza EL Hendriks. 2018. “Invasive Aspergillosis Mimicking Metastatic Lung Cancer.” Frontiers in Oncology 8.
Chicago author-date (all authors)
Vanfleteren, Michiel, Anne-Marie C Dingemans, Veerle Surmont, Karim Vermaelen, Alida A Postma, Astrid ML Oude lashof, Cordula CM Pitz, and Lizza EL Hendriks. 2018. “Invasive Aspergillosis Mimicking Metastatic Lung Cancer.” Frontiers in Oncology 8.
Vancouver
1.
Vanfleteren M, Dingemans A-MC, Surmont V, Vermaelen K, Postma AA, Oude lashof AM, et al. Invasive aspergillosis mimicking metastatic lung cancer. FRONTIERS IN ONCOLOGY. 2018;8.
IEEE
[1]
M. Vanfleteren et al., “Invasive aspergillosis mimicking metastatic lung cancer,” FRONTIERS IN ONCOLOGY, vol. 8, 2018.
@article{8601285,
  abstract     = {In a patient with a medical history of cancer, the most probable diagnosis of an (18)FDG-avid pulmonary mass combined with intracranial abnormalities on brain imaging is metastasized cancer. However, sometimes a differential diagnosis with an infectious cause such as aspergillosis can be very challenging as both cancer and infection are sometimes difficult to distinguish. Pulmonary aspergillosis can present as an infectious pseudotumour with clinical and imaging characteristics mimicking lung cancer. Even in the presence of cerebral lesions, radiological appearance of abscesses can look like brain metastasis. These similarities can cause significant diagnostic difficulties with a subsequent therapeutic delay and a potential adverse outcome. Awareness of this infectious disease that can mimic lung cancer, even in an immunocompetent patient, is important. We report a case of a 65-year-old woman with pulmonary aspergillosis disseminated to the brain mimicking metastatic lung cancer.},
  articleno    = {188},
  author       = {Vanfleteren, Michiel and Dingemans, Anne-Marie C and Surmont, Veerle and Vermaelen, Karim and Postma, Alida A and Oude lashof, Astrid ML and Pitz, Cordula CM and Hendriks, Lizza EL},
  issn         = {2234-943X},
  journal      = {FRONTIERS IN ONCOLOGY},
  keywords     = {PULMONARY ASPERGILLOSIS,COMPUTED-TOMOGRAPHY,BRAIN METASTASES,DIAGNOSIS,MRI,CT,lung cancer,lung neoplasms,brain metastasis,brain neoplasms,brain,abscess,aspergillosis,differential diagnosis},
  language     = {eng},
  pages        = {7},
  title        = {Invasive aspergillosis mimicking metastatic lung cancer},
  url          = {http://dx.doi.org/10.3389/fonc.2018.00188},
  volume       = {8},
  year         = {2018},
}

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