Advanced search
1 file | 1.87 MB

Comparison of ERS'93 to the newly published GLI'17 reference values for carbon monoxide transfer factor

(2019) RESPIRATORY MEDICINE. 146. p.113-115
Author
Organization
Abstract
Background: The new predicted values for the carbon monoxide transfer factor (TL, CO) for Caucasians by the Global Lung Function Initiative are available since September 2017. Several authors have previously shown that the predicted values of Cotes et al. (ERS'93), overestimated TL, CO. However, the GLI'17 authors omitted to compare their predicted values with the ERS'93 equations, still in use throughout Europe. We present the differences between the two sets of predicted values, and in an attempt to improve the readability, used the contour plots instead of the classical 2-dimensional representations. Methods: Predicted values were computed for males and females for ages between 18 and 70 years and heights between 155 and 180 cm using Matlab software with increments of one unit (1 yr, 1 cm). Results: We demonstrate that GLI-'17 predicted values of TL, CO are systematically lower than those of ERS-'93, but also that the magnitude of the differences varies according to age, height and sex. More specifically, differences increase in both males and females by decreasing age and height, reaching up to 16% in males and 24% in females. Conclusion: The predicted values of TL, CO by Cotes at al. are systematically larger than the new GLI' 17 values. Plotting all the possible differences between predicted variables using contour graphs allows to identify the groups of subjects in whom significant changes in their predicted values will occur. Our findings should prompt physicians to investigate how switching to GLI-17 equations affects the clinical interpretation of TL, CO measurements in a real-live setting.
Keywords
SPIROMETRY, Carbon monoxide transfer factor, Pulmonary function tests, Reference, values

Downloads

  • 1-s2.0-S0954611118303913-main.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.87 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Oostveen, Ellie, Eric Derom, Anne-Marie Vints, and Giuseppe Liistro. 2019. “Comparison of ERS’93 to the Newly Published GLI'17 Reference Values for Carbon Monoxide Transfer Factor.” Respiratory Medicine 146: 113–115.
APA
Oostveen, E., Derom, E., Vints, A.-M., & Liistro, G. (2019). Comparison of ERS’93 to the newly published GLI'17 reference values for carbon monoxide transfer factor. RESPIRATORY MEDICINE, 146, 113–115.
Vancouver
1.
Oostveen E, Derom E, Vints A-M, Liistro G. Comparison of ERS’93 to the newly published GLI'17 reference values for carbon monoxide transfer factor. RESPIRATORY MEDICINE. London: W B Saunders Co Ltd; 2019;146:113–5.
MLA
Oostveen, Ellie et al. “Comparison of ERS’93 to the Newly Published GLI'17 Reference Values for Carbon Monoxide Transfer Factor.” RESPIRATORY MEDICINE 146 (2019): 113–115. Print.
@article{8601235,
  abstract     = {Background: The new predicted values for the carbon monoxide transfer factor (TL, CO) for Caucasians by the Global Lung Function Initiative are available since September 2017. Several authors have previously shown that the predicted values of Cotes et al. (ERS'93), overestimated TL, CO. However, the GLI'17 authors omitted to compare their predicted values with the ERS'93 equations, still in use throughout Europe. We present the differences between the two sets of predicted values, and in an attempt to improve the readability, used the contour plots instead of the classical 2-dimensional representations. Methods: Predicted values were computed for males and females for ages between 18 and 70 years and heights between 155 and 180 cm using Matlab software with increments of one unit (1 yr, 1 cm). Results: We demonstrate that GLI-'17 predicted values of TL, CO are systematically lower than those of ERS-'93, but also that the magnitude of the differences varies according to age, height and sex. More specifically, differences increase in both males and females by decreasing age and height, reaching up to 16\% in males and 24\% in females. Conclusion: The predicted values of TL, CO by Cotes at al. are systematically larger than the new GLI' 17 values. Plotting all the possible differences between predicted variables using contour graphs allows to identify the groups of subjects in whom significant changes in their predicted values will occur. Our findings should prompt physicians to investigate how switching to GLI-17 equations affects the clinical interpretation of TL, CO measurements in a real-live setting.},
  author       = {Oostveen, Ellie and Derom, Eric and Vints, Anne-Marie and Liistro, Giuseppe},
  issn         = {0954-6111},
  journal      = {RESPIRATORY MEDICINE},
  language     = {eng},
  pages        = {113--115},
  publisher    = {W B Saunders Co Ltd},
  title        = {Comparison of ERS'93 to the newly published GLI'17 reference values for carbon monoxide transfer factor},
  url          = {http://dx.doi.org/10.1016/j.rmed.2018.12.005},
  volume       = {146},
  year         = {2019},
}

Altmetric
View in Altmetric
Web of Science
Times cited: