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The emerging role of ADAM metalloproteinases in immunity

Bart Lambrecht (UGent) , Matthias Vanderkerken (UGent) and Hamida Hammad (UGent)
(2018) NATURE REVIEWS IMMUNOLOGY. 18(12). p.745-758
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Abstract
Proteolysis is an irreversible physiological process that can result in the termination or activation of protein function. Many transmembrane proteins that are involved in the cellular communication between immune cells and structural cells-for example, Notch, CD23, CD44, and membrane-anchored cytokines and their receptors-are cleaved by the ADAM (a disintegrin and metalloproteinase) family of enzymes. Here, we review recent insights into the molecular activation, substrate specificity and function of ADAM proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17.
Keywords
ALPHA-CONVERTING-ENZYME, T-CELL IMMUNOGLOBULIN, ZONE B-CELLS, NECROSIS-FACTOR-ALPHA, MUCIN DOMAIN 3, PROTEOLYTIC ACTIVATION, TSPANC8, TETRASPANINS, PHOSPHATIDYLSERINE EXPOSURE, SURFACE EXPRESSION, CYTOPLASMIC DOMAIN

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Chicago
Lambrecht, Bart, Matthias Vanderkerken, and Hamida Hammad. 2018. “The Emerging Role of ADAM Metalloproteinases in Immunity.” Nature Reviews Immunology 18 (12): 745–758.
APA
Lambrecht, B., Vanderkerken, M., & Hammad, H. (2018). The emerging role of ADAM metalloproteinases in immunity. NATURE REVIEWS IMMUNOLOGY, 18(12), 745–758.
Vancouver
1.
Lambrecht B, Vanderkerken M, Hammad H. The emerging role of ADAM metalloproteinases in immunity. NATURE REVIEWS IMMUNOLOGY. 2018;18(12):745–58.
MLA
Lambrecht, Bart, Matthias Vanderkerken, and Hamida Hammad. “The Emerging Role of ADAM Metalloproteinases in Immunity.” NATURE REVIEWS IMMUNOLOGY 18.12 (2018): 745–758. Print.
@article{8600892,
  abstract     = {Proteolysis is an irreversible physiological process that can result in the termination or activation of protein function. Many transmembrane proteins that are involved in the cellular communication between immune cells and structural cells-for example, Notch, CD23, CD44, and membrane-anchored cytokines and their receptors-are cleaved by the ADAM (a disintegrin and metalloproteinase) family of enzymes. Here, we review recent insights into the molecular activation, substrate specificity and function of ADAM proteins in the development and regulation of the immune system, with a particular focus on the roles of ADAM10 and ADAM17.},
  author       = {Lambrecht, Bart and Vanderkerken, Matthias and Hammad, Hamida},
  issn         = {1474-1733},
  journal      = {NATURE REVIEWS IMMUNOLOGY},
  keywords     = {ALPHA-CONVERTING-ENZYME,T-CELL IMMUNOGLOBULIN,ZONE B-CELLS,NECROSIS-FACTOR-ALPHA,MUCIN DOMAIN 3,PROTEOLYTIC ACTIVATION,TSPANC8,TETRASPANINS,PHOSPHATIDYLSERINE EXPOSURE,SURFACE EXPRESSION,CYTOPLASMIC DOMAIN},
  language     = {eng},
  number       = {12},
  pages        = {745--758},
  title        = {The emerging role of ADAM metalloproteinases in immunity},
  url          = {http://dx.doi.org/10.1038/s41577-018-0068-5},
  volume       = {18},
  year         = {2018},
}

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