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3'-Phosphoadenosine 5'-phosphate accumulation delays the circadian system

(2018) PLANT PHYSIOLOGY. 176(4). p.3120-3135
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Abstract
The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear. Redox regulation of the SAL1 phosphatase during abiotic stress initiates a signaling pathway from chloroplast to nucleus by regulating the accumulation of a metabolite, 3'-phosphoadenosine 5'-phosphate (PAP). Consequently, PAP accumulates in response to redox stress and inhibits the activity of exoribonucleases (XRNs) in the nucleus and cytosol. We demonstrated that osmotic stress induces a lengthening of circadian period and that genetically inducing the SAL1-PAP-XRN pathway in plants lacking either SAL1 or XRNs similarly delays the circadian system. Exogenous application of PAP was also sufficient to extend circadian period. Thus, SAL1-PAP-XRN signaling likely regulates circadian rhythms in response to redox stress. Our findings exemplify how two central processes in plants, molecular timekeeping and responses to abiotic stress, can be interlinked to regulate gene expression.
Keywords
PSEUDO-RESPONSE REGULATORS, INOSITOL POLYPHOSPHATE 1-PHOSPHATASE, ARABIDOPSIS-THALIANA, ABIOTIC STRESS, OXIDATIVE STRESS, FLOWERING TIME, 3(2), 5-BISPHOSPHATE NUCLEOTIDASE, TRANSCRIPTION FACTOR, SIGNAL-TRANSDUCTION, NEGATIVE REGULATOR

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Citation

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MLA
Litthauer, Suzanne, Kai Xun Chan, and Matthew Alan Jones. “3’-Phosphoadenosine 5'-phosphate Accumulation Delays the Circadian System.” PLANT PHYSIOLOGY 176.4 (2018): 3120–3135. Print.
APA
Litthauer, S., Chan, K. X., & Jones, M. A. (2018). 3’-Phosphoadenosine 5'-phosphate accumulation delays the circadian system. PLANT PHYSIOLOGY, 176(4), 3120–3135.
Chicago author-date
Litthauer, Suzanne, Kai Xun Chan, and Matthew Alan Jones. 2018. “3’-Phosphoadenosine 5'-phosphate Accumulation Delays the Circadian System.” Plant Physiology 176 (4): 3120–3135.
Chicago author-date (all authors)
Litthauer, Suzanne, Kai Xun Chan, and Matthew Alan Jones. 2018. “3’-Phosphoadenosine 5'-phosphate Accumulation Delays the Circadian System.” Plant Physiology 176 (4): 3120–3135.
Vancouver
1.
Litthauer S, Chan KX, Jones MA. 3’-Phosphoadenosine 5'-phosphate accumulation delays the circadian system. PLANT PHYSIOLOGY. 2018;176(4):3120–35.
IEEE
[1]
S. Litthauer, K. X. Chan, and M. A. Jones, “3’-Phosphoadenosine 5’-phosphate accumulation delays the circadian system,” PLANT PHYSIOLOGY, vol. 176, no. 4, pp. 3120–3135, 2018.
@article{8600845,
  abstract     = {The circadian system optimizes cellular responses to stress, but the signaling pathways that convey the metabolic consequences of stress into this molecular timekeeping mechanism remain unclear. Redox regulation of the SAL1 phosphatase during abiotic stress initiates a signaling pathway from chloroplast to nucleus by regulating the accumulation of a metabolite, 3'-phosphoadenosine 5'-phosphate (PAP). Consequently, PAP accumulates in response to redox stress and inhibits the activity of exoribonucleases (XRNs) in the nucleus and cytosol. We demonstrated that osmotic stress induces a lengthening of circadian period and that genetically inducing the SAL1-PAP-XRN pathway in plants lacking either SAL1 or XRNs similarly delays the circadian system. Exogenous application of PAP was also sufficient to extend circadian period. Thus, SAL1-PAP-XRN signaling likely regulates circadian rhythms in response to redox stress. Our findings exemplify how two central processes in plants, molecular timekeeping and responses to abiotic stress, can be interlinked to regulate gene expression.},
  author       = {Litthauer, Suzanne and Chan, Kai Xun and Jones, Matthew Alan},
  issn         = {0032-0889},
  journal      = {PLANT PHYSIOLOGY},
  keywords     = {PSEUDO-RESPONSE REGULATORS,INOSITOL POLYPHOSPHATE 1-PHOSPHATASE,ARABIDOPSIS-THALIANA,ABIOTIC STRESS,OXIDATIVE STRESS,FLOWERING TIME,3(2),5-BISPHOSPHATE NUCLEOTIDASE,TRANSCRIPTION FACTOR,SIGNAL-TRANSDUCTION,NEGATIVE REGULATOR},
  language     = {eng},
  number       = {4},
  pages        = {3120--3135},
  title        = {3'-Phosphoadenosine 5'-phosphate accumulation delays the circadian system},
  url          = {http://dx.doi.org/10.1104/pp.17.01611},
  volume       = {176},
  year         = {2018},
}

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