Advanced search
1 file | 533.57 KB

Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies

(2018) RHEUMATOLOGY. 58(1). p.120-130
Author
Organization
Abstract
Objective: The aim of this study was to investigate the clinical and immunological significance of nailfold videocapillaroscopy (NVC) abnormalities in patients with idiopathic inflammatory myopathies (IIMs). Methods: Seventy consecutive Japanese patients with untreated IIMs, enrolled between April 2014 and August 2017, were prospectively studied. Clinical features, NVC findings, autoantibody profile by immunoprecipitation and ELISA, and histopathological findings of skin biopsies of DM rash were assessed at baseline and after 1-year of immunosuppressive therapy. Results: NVC abnormalities were found in 55.7% (39/70) of IIM patients, with significantly higher prevalence in DM (65.4%) compared with PM (27.8%) (P = 0.01). In subsets of patients classified by autoantibody specificities, the prevalence of NVC abnormalities was significantly higher in patients with anti-MDA5 (87.5%) and anti-transcriptional intermediary factor 1 gamma (88.9%) vs anti-aminoacyl-tRNA synthetase (26.9%, P < 0.001). Perivascular lymphocytic infiltration in the upper dermis of skin rash biopsy of DM was more severe in patients with NVC abnormalities (P < 0.05). Unexpectedly, NVC abnormalities disappeared in 75% of IIM patients after 1-year of immunosuppressive therapy in contrast to stable NVC changes seen in scleroderma patients. Conclusion: Nailfold microvascular abnormalities were common in DM patients, associated with anti-MDA5 and transcriptional intermediary factor 1 gamma antibodies, and perivascular inflammation in skin histology. NVC abnormalities in IIMs may become clinically useful markers for defining subsets of DM and understanding the pathogenesis of the clinical features seen in these patients.
Keywords
DM, PM, nailfold videocapillaroscopy, nnyositis-specific autoantibodies, systemic sclerosis, RHEUMATOLOGY CLASSIFICATION CRITERIA, 2017 EUROPEAN LEAGUE, SYSTEMIC-SCLEROSIS, RHEUMATISM/AMERICAN COLLEGE, IMMUNOSUPPRESSIVE TREATMENT, CAPILLAROSCOPIC ANALYSIS, MICROVASCULAR CHANGES, AMERICAN-COLLEGE, DERMATOMYOSITIS, POLYMYOSITIS

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 533.57 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Kubo, Satoshi, Yasuyuki Todoroki, Shingo Nakayamada, Kazuhisa Nakano, Minoru Satoh, Aya Nawata, Yurie Satoh, et al. 2018. “Significance of Nailfold Videocapillaroscopy in Patients with Idiopathic Inflammatory Myopathies.” Rheumatology 58 (1): 120–130.
APA
Kubo, S., Todoroki, Y., Nakayamada, S., Nakano, K., Satoh, M., Nawata, A., Satoh, Y., et al. (2018). Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies. RHEUMATOLOGY, 58(1), 120–130.
Vancouver
1.
Kubo S, Todoroki Y, Nakayamada S, Nakano K, Satoh M, Nawata A, et al. Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies. RHEUMATOLOGY. 2018;58(1):120–30.
MLA
Kubo, Satoshi et al. “Significance of Nailfold Videocapillaroscopy in Patients with Idiopathic Inflammatory Myopathies.” RHEUMATOLOGY 58.1 (2018): 120–130. Print.
@article{8600430,
  abstract     = {Objective: The aim of this study was to investigate the clinical and immunological significance of nailfold videocapillaroscopy (NVC) abnormalities in patients with idiopathic inflammatory myopathies (IIMs). 
Methods: Seventy consecutive Japanese patients with untreated IIMs, enrolled between April 2014 and August 2017, were prospectively studied. Clinical features, NVC findings, autoantibody profile by immunoprecipitation and ELISA, and histopathological findings of skin biopsies of DM rash were assessed at baseline and after 1-year of immunosuppressive therapy. 
Results: NVC abnormalities were found in 55.7% (39/70) of IIM patients, with significantly higher prevalence in DM (65.4%) compared with PM (27.8%) (P = 0.01). In subsets of patients classified by autoantibody specificities, the prevalence of NVC abnormalities was significantly higher in patients with anti-MDA5 (87.5%) and anti-transcriptional intermediary factor 1 gamma (88.9%) vs anti-aminoacyl-tRNA synthetase (26.9%, P < 0.001). Perivascular lymphocytic infiltration in the upper dermis of skin rash biopsy of DM was more severe in patients with NVC abnormalities (P < 0.05). Unexpectedly, NVC abnormalities disappeared in 75% of IIM patients after 1-year of immunosuppressive therapy in contrast to stable NVC changes seen in scleroderma patients. 
Conclusion: Nailfold microvascular abnormalities were common in DM patients, associated with anti-MDA5 and transcriptional intermediary factor 1 gamma antibodies, and perivascular inflammation in skin histology. NVC abnormalities in IIMs may become clinically useful markers for defining subsets of DM and understanding the pathogenesis of the clinical features seen in these patients.},
  author       = {Kubo, Satoshi and Todoroki, Yasuyuki and Nakayamada, Shingo and Nakano, Kazuhisa and Satoh, Minoru and Nawata, Aya and Satoh, Yurie and Miyagawa, Ippei and Saito, Kazuyoshi and Smith, Vanessa and Cutolo, Maurizio and Tanaka, Yoshiya},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  keywords     = {DM,PM,nailfold videocapillaroscopy,nnyositis-specific autoantibodies,systemic sclerosis,RHEUMATOLOGY CLASSIFICATION CRITERIA,2017 EUROPEAN LEAGUE,SYSTEMIC-SCLEROSIS,RHEUMATISM/AMERICAN COLLEGE,IMMUNOSUPPRESSIVE TREATMENT,CAPILLAROSCOPIC ANALYSIS,MICROVASCULAR CHANGES,AMERICAN-COLLEGE,DERMATOMYOSITIS,POLYMYOSITIS},
  language     = {eng},
  number       = {1},
  pages        = {120--130},
  title        = {Significance of nailfold videocapillaroscopy in patients with idiopathic inflammatory myopathies},
  url          = {http://dx.doi.org/10.1093/rheumatology/key257},
  volume       = {58},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: