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The eGVHD App has the potential to improve the accuracy of graft-versus-host disease assessment : a multicenter randomized controlled trial

(2018) HAEMATOLOGICA. 103(10). p.1698-1707
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Organization
Abstract
Graft-versus-host disease (GvHD) assessment has been shown to be a challenge for healthcare professionals, leading to the development of the eGVHD App (www.uzleuven.be/egvhd). In this study, we formally evaluated the accuracy of using the App compared to traditional assessment methods to assess GvHD. Our national multicenter randomized controlled trial involved seven Belgian transplantation centers and 78 healthcare professionals selected using a 2-stage convenience sampling approach between January and April 2017. Using a 1:1 randomization stratified by profession, healthcare professionals were assigned to use either the App ("APP") or their usual GvHD assessment aids ("No APP") to assess the diagnosis and severity score of 10 expert-validated clinical vignettes. Our main outcome measure was the difference in accuracy for GvHD severity scoring between both groups. The odds of being correct were 6.14 (95% CI: 2.83-13.34) and 6.29 (95% CI: 4.32-9.15) times higher in favor of the "APP" group for diagnosis and scoring, respectively (P<0.001). Appassisted GvHD severity scoring was significantly superior for both acute and chronic GvHD, with an Odds Ratio of 17.89 and 4.34 respectively (P<0.001) and showed a significantly increased inter-observer agreement compared to standard practice. Despite a mean increase of 24 minutes (95% CI: 20.45-26.97) in the time needed to score the whole GvHD test package in the "APP" group (P<0.001), usability feedback was positive. The eGVHD App shows superior GvHD assessment accuracy compared to standard practice and has the potential to improve the quality of outcome data registration in allogeneic stem cell transplantation.
Keywords
CONSENSUS DEVELOPMENT PROJECT, WORKING GROUP-REPORT, CLINICAL-TRIALS, THERAPEUTIC RESPONSE, NIH CRITERIA, ACUTE GVHD, DIAGNOSIS, MARROW, CGVHD

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MLA
Schoemans, Helene M et al. “The eGVHD App Has the Potential to Improve the Accuracy of Graft-versus-host Disease Assessment : a Multicenter Randomized Controlled Trial.” HAEMATOLOGICA 103.10 (2018): 1698–1707. Print.
APA
Schoemans, H. M., Goris, K., Van Durm, R., Fieuws, S., De Geest, S., Pavletic, S. Z., Im, A., et al. (2018). The eGVHD App has the potential to improve the accuracy of graft-versus-host disease assessment : a multicenter randomized controlled trial. HAEMATOLOGICA, 103(10), 1698–1707.
Chicago author-date
Schoemans, Helene M, Kathy Goris, Raf Van Durm, Steffen Fieuws, Sabina De Geest, Steven Z Pavletic, Annie Im, et al. 2018. “The eGVHD App Has the Potential to Improve the Accuracy of Graft-versus-host Disease Assessment : a Multicenter Randomized Controlled Trial.” Haematologica 103 (10): 1698–1707.
Chicago author-date (all authors)
Schoemans, Helene M, Kathy Goris, Raf Van Durm, Steffen Fieuws, Sabina De Geest, Steven Z Pavletic, Annie Im, Daniel Wolff, Stephanie J Lee, Hildegard Greinix, Rafael F Duarte, Xavier Poire, Dominik Selleslag, Philippe Lewalle, Tessa Kerre, Carlos Graux, Frederic Baron, Johan A Maertens, and Fabienne Dobbels. 2018. “The eGVHD App Has the Potential to Improve the Accuracy of Graft-versus-host Disease Assessment : a Multicenter Randomized Controlled Trial.” Haematologica 103 (10): 1698–1707.
Vancouver
1.
Schoemans HM, Goris K, Van Durm R, Fieuws S, De Geest S, Pavletic SZ, et al. The eGVHD App has the potential to improve the accuracy of graft-versus-host disease assessment : a multicenter randomized controlled trial. HAEMATOLOGICA. 2018;103(10):1698–707.
IEEE
[1]
H. M. Schoemans et al., “The eGVHD App has the potential to improve the accuracy of graft-versus-host disease assessment : a multicenter randomized controlled trial,” HAEMATOLOGICA, vol. 103, no. 10, pp. 1698–1707, 2018.
@article{8600152,
  abstract     = {Graft-versus-host disease (GvHD) assessment has been shown to be a challenge for healthcare professionals, leading to the development of the eGVHD App (www.uzleuven.be/egvhd). In this study, we formally evaluated the accuracy of using the App compared to traditional assessment methods to assess GvHD. Our national multicenter randomized controlled trial involved seven Belgian transplantation centers and 78 healthcare professionals selected using a 2-stage convenience sampling approach between January and April 2017. Using a 1:1 randomization stratified by profession, healthcare professionals were assigned to use either the App ("APP") or their usual GvHD assessment aids ("No APP") to assess the diagnosis and severity score of 10 expert-validated clinical vignettes. Our main outcome measure was the difference in accuracy for GvHD severity scoring between both groups. The odds of being correct were 6.14 (95% CI: 2.83-13.34) and 6.29 (95% CI: 4.32-9.15) times higher in favor of the "APP" group for diagnosis and scoring, respectively (P<0.001). Appassisted GvHD severity scoring was significantly superior for both acute and chronic GvHD, with an Odds Ratio of 17.89 and 4.34 respectively (P<0.001) and showed a significantly increased inter-observer agreement compared to standard practice. Despite a mean increase of 24 minutes (95% CI: 20.45-26.97) in the time needed to score the whole GvHD test package in the "APP" group (P<0.001), usability feedback was positive. The eGVHD App shows superior GvHD assessment accuracy compared to standard practice and has the potential to improve the quality of outcome data registration in allogeneic stem cell transplantation.},
  author       = {Schoemans, Helene M and Goris, Kathy and Van Durm, Raf and Fieuws, Steffen and De Geest, Sabina and Pavletic, Steven Z and Im, Annie and Wolff, Daniel and Lee, Stephanie J and Greinix, Hildegard and Duarte, Rafael F and Poire, Xavier and Selleslag, Dominik and Lewalle, Philippe and Kerre, Tessa and Graux, Carlos and Baron, Frederic and Maertens, Johan A and Dobbels, Fabienne},
  issn         = {0390-6078},
  journal      = {HAEMATOLOGICA},
  keywords     = {CONSENSUS DEVELOPMENT PROJECT,WORKING GROUP-REPORT,CLINICAL-TRIALS,THERAPEUTIC RESPONSE,NIH CRITERIA,ACUTE GVHD,DIAGNOSIS,MARROW,CGVHD},
  language     = {eng},
  number       = {10},
  pages        = {1698--1707},
  title        = {The eGVHD App has the potential to improve the accuracy of graft-versus-host disease assessment : a multicenter randomized controlled trial},
  url          = {http://dx.doi.org/10.3324/haematol.2018.190777},
  volume       = {103},
  year         = {2018},
}

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