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Abstract
Synthetic polymers have had a major impact on the biomedical field. However, all polymers have their advantages and disadvantages, so that the selection of a certain polymeric material always is a compromise with regard to many properties, such as synthetic accessibility, solubility, thermal properties, biocompatibility, and degradability. The development of novel polymers with superior properties for medical applications is the focus of many research groups. The present study highlights the use of poly(2-isopropenyl-2-oxazoline) (PiPOx), as biocompatible functional polymer to develop synthetic hydrogel materials using a simple straightforward synthesis protocol. A library of hydrogels was obtained by chemical cross-linking of PiPO(x), using eight different nontoxic and bio-based dicarboxylic acids. The equilibrium swelling degree of the final material can be modulated by simple modification of the composition of the reaction mixture, including the polymer concentration in the feed ratio between the 2-oxazoline pendent groups and the carboxylic acid groups as well as the cross-linker length. The hydrogels with the highest water uptake were selected for further investigations regarding their potential use as biomaterials. We evaluated the thermoresponsiveness, the pH degradability under physiological conditions, and demonstrated proof-of-concept drug delivery experiments. The in vitro cellular studies demonstrated the noncytotoxic character of the PiPOx hydrogels, and their protein repellent properties, while mineralization studies revealed that such scaffolds do not promote mineralization/calcification phenomena. In view of these results, these hydrogels show potential use as ophthalmologic materials or in drug delivery applications.
Keywords
POLY(2-OXAZOLINE) HYDROGELS, DRUG-DELIVERY, IN-VITRO, TISSUE, POLYMERIZATION, BIOMATERIALS, COPOLYMERS, DRESSINGS, KINETICS, DESIGN

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Citation

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MLA
Jerca, Florica Adriana, et al. “Poly(2-Isopropenyl-2-Oxazoline) Hydrogels for Biomedical Applications.” CHEMISTRY OF MATERIALS, vol. 30, no. 21, 2018, pp. 7938–49, doi:10.1021/acs.chemmater.8b03545.
APA
Jerca, F. A., Anghelache, A. M., Ghibu, E., Cecoltan, S., Stancu, I.-C., Trusca, R., … Jerca, V.-V. (2018). Poly(2-isopropenyl-2-oxazoline) hydrogels for biomedical applications. CHEMISTRY OF MATERIALS, 30(21), 7938–7949. https://doi.org/10.1021/acs.chemmater.8b03545
Chicago author-date
Jerca, Florica Adriana, Alina Maria Anghelache, Emilian Ghibu, Sergiu Cecoltan, Izabela-Cristina Stancu, Roxana Trusca, Eugeniu Vasile, et al. 2018. “Poly(2-Isopropenyl-2-Oxazoline) Hydrogels for Biomedical Applications.” CHEMISTRY OF MATERIALS 30 (21): 7938–49. https://doi.org/10.1021/acs.chemmater.8b03545.
Chicago author-date (all authors)
Jerca, Florica Adriana, Alina Maria Anghelache, Emilian Ghibu, Sergiu Cecoltan, Izabela-Cristina Stancu, Roxana Trusca, Eugeniu Vasile, Mircea Teodorescu, Dumitru Mircea Vuluga, Richard Hoogenboom, and Valentin-Victor Jerca. 2018. “Poly(2-Isopropenyl-2-Oxazoline) Hydrogels for Biomedical Applications.” CHEMISTRY OF MATERIALS 30 (21): 7938–7949. doi:10.1021/acs.chemmater.8b03545.
Vancouver
1.
Jerca FA, Anghelache AM, Ghibu E, Cecoltan S, Stancu I-C, Trusca R, et al. Poly(2-isopropenyl-2-oxazoline) hydrogels for biomedical applications. CHEMISTRY OF MATERIALS. 2018;30(21):7938–49.
IEEE
[1]
F. A. Jerca et al., “Poly(2-isopropenyl-2-oxazoline) hydrogels for biomedical applications,” CHEMISTRY OF MATERIALS, vol. 30, no. 21, pp. 7938–7949, 2018.
@article{8600132,
  abstract     = {{Synthetic polymers have had a major impact on the biomedical field. However, all polymers have their advantages and disadvantages, so that the selection of a certain polymeric material always is a compromise with regard to many properties, such as synthetic accessibility, solubility, thermal properties, biocompatibility, and degradability. The development of novel polymers with superior properties for medical applications is the focus of many research groups. The present study highlights the use of poly(2-isopropenyl-2-oxazoline) (PiPOx), as biocompatible functional polymer to develop synthetic hydrogel materials using a simple straightforward synthesis protocol. A library of hydrogels was obtained by chemical cross-linking of PiPO(x), using eight different nontoxic and bio-based dicarboxylic acids. The equilibrium swelling degree of the final material can be modulated by simple modification of the composition of the reaction mixture, including the polymer concentration in the feed ratio between the 2-oxazoline pendent groups and the carboxylic acid groups as well as the cross-linker length. The hydrogels with the highest water uptake were selected for further investigations regarding their potential use as biomaterials. We evaluated the thermoresponsiveness, the pH degradability under physiological conditions, and demonstrated proof-of-concept drug delivery experiments. The in vitro cellular studies demonstrated the noncytotoxic character of the PiPOx hydrogels, and their protein repellent properties, while mineralization studies revealed that such scaffolds do not promote mineralization/calcification phenomena. In view of these results, these hydrogels show potential use as ophthalmologic materials or in drug delivery applications.}},
  author       = {{Jerca, Florica Adriana and Anghelache, Alina Maria and Ghibu, Emilian and Cecoltan, Sergiu and Stancu, Izabela-Cristina and Trusca, Roxana and Vasile, Eugeniu and Teodorescu, Mircea and Vuluga, Dumitru Mircea and Hoogenboom, Richard and Jerca, Valentin-Victor}},
  issn         = {{0897-4756}},
  journal      = {{CHEMISTRY OF MATERIALS}},
  keywords     = {{POLY(2-OXAZOLINE) HYDROGELS,DRUG-DELIVERY,IN-VITRO,TISSUE,POLYMERIZATION,BIOMATERIALS,COPOLYMERS,DRESSINGS,KINETICS,DESIGN}},
  language     = {{eng}},
  number       = {{21}},
  pages        = {{7938--7949}},
  title        = {{Poly(2-isopropenyl-2-oxazoline) hydrogels for biomedical applications}},
  url          = {{http://dx.doi.org/10.1021/acs.chemmater.8b03545}},
  volume       = {{30}},
  year         = {{2018}},
}

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