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Oxygen reserve index : validation of a new variable

(2019) ANESTHESIA AND ANALGESIA. 129(2). p.409-415
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Abstract
BACKGROUND: Pulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (Pao(2)) in the range of 100-200 mm Hg, may allow additional monitoring of oxygen status. METHODS: In this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00-1.00) were compared with measured Pao(2) values. Repeated-measurements correlation analysis was performed to assess the ORi/Pao(2) relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged Pao(2), <100 mm Hg). RESULTS: Within the ORi-sensitive range, a strong positive correlation was found between ORi and Pao(2) for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of Pao(2) was good within this range (concordance rate = 94%). The prediction of Pao(2) <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity. CONCLUSIONS: In this prospective volunteer validation study, a strong and positive correlation between Pao(2) and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.
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MLA
Vos, Jaap Jan, et al. “Oxygen Reserve Index : Validation of a New Variable.” ANESTHESIA AND ANALGESIA, vol. 129, no. 2, 2019, pp. 409–15.
APA
Vos, J. J., Willems, C. H., van Amsterdam, K., van den Berg, J. P., Spanjersberg, R., Struys, M., & Scheeren, T. W. (2019). Oxygen reserve index : validation of a new variable. ANESTHESIA AND ANALGESIA, 129(2), 409–415.
Chicago author-date
Vos, Jaap Jan, Cornelis H Willems, Kai van Amsterdam, Johannes P van den Berg, Rob Spanjersberg, Michel Struys, and Thomas WL Scheeren. 2019. “Oxygen Reserve Index : Validation of a New Variable.” ANESTHESIA AND ANALGESIA 129 (2): 409–15.
Chicago author-date (all authors)
Vos, Jaap Jan, Cornelis H Willems, Kai van Amsterdam, Johannes P van den Berg, Rob Spanjersberg, Michel Struys, and Thomas WL Scheeren. 2019. “Oxygen Reserve Index : Validation of a New Variable.” ANESTHESIA AND ANALGESIA 129 (2): 409–415.
Vancouver
1.
Vos JJ, Willems CH, van Amsterdam K, van den Berg JP, Spanjersberg R, Struys M, et al. Oxygen reserve index : validation of a new variable. ANESTHESIA AND ANALGESIA. 2019;129(2):409–15.
IEEE
[1]
J. J. Vos et al., “Oxygen reserve index : validation of a new variable,” ANESTHESIA AND ANALGESIA, vol. 129, no. 2, pp. 409–415, 2019.
@article{8600015,
  abstract     = {BACKGROUND: Pulse oximetry-derived oxygen saturation is typically >97% in normoxia and hyperoxia, limiting its clinical use. The new Oxygen Reserve Index (ORi), a relative indicator of the partial pressure of oxygen dissolved in arterial blood (Pao(2)) in the range of 100-200 mm Hg, may allow additional monitoring of oxygen status.
METHODS: In this prospective validation intervention study, 20 healthy volunteers were breathing standardized oxygen concentrations ranging from mild hypoxia (fraction of inspired oxygen = 0.14) to hyperoxia (fraction of inspired oxygen = 1.0) via a tight-fitting face mask. ORi was measured noninvasively by multiwavelength pulse co-oximetry using 2 finger sensors. These ORi values (unitless scale, 0.00-1.00) were compared with measured Pao(2) values. Repeated-measurements correlation analysis was performed to assess the ORi/Pao(2) relationship. ORi trending ability was assessed using a 4-quadrant plot. The area under the receiver operating characteristics curve was calculated to assess the prediction of hypoxia (low-ranged Pao(2), <100 mm Hg).
RESULTS: Within the ORi-sensitive range, a strong positive correlation was found between ORi and Pao(2) for both sensors (R = 0.78 and 0.83; P < .0001). ORi trending of Pao(2) was good within this range (concordance rate = 94%). The prediction of Pao(2) <100 mm Hg was also good, with an area under the receiver operating characteristics curve of 0.91 and 99% sensitivity and 82% specificity.
CONCLUSIONS: In this prospective volunteer validation study, a strong and positive correlation between Pao(2) and ORi was found, together with a good trending ability. Based on these data, the future use of ORi as a continuous noninvasive monitoring tool for assessing oxygenation status in patients receiving supplemental oxygen might be supported.},
  author       = {Vos, Jaap Jan and Willems, Cornelis H and van Amsterdam, Kai and van den Berg, Johannes P and Spanjersberg, Rob and Struys, Michel and Scheeren, Thomas WL},
  issn         = {0003-2999},
  journal      = {ANESTHESIA AND ANALGESIA},
  keywords     = {ANESTHESIA},
  language     = {eng},
  number       = {2},
  pages        = {409--415},
  title        = {Oxygen reserve index : validation of a new variable},
  url          = {http://dx.doi.org/10.1213/ane.0000000000003706},
  volume       = {129},
  year         = {2019},
}

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