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Stationary-phase optimized selectivity in liquid chromatography (SOS-LC) for pharmaceutical analysis

Frederic Lynen (UGent) , Ravindra Suryakant Hegade (UGent) , Maarten De Beer (UGent) , Kai Chen (UGent) , Sander Delahaye (UGent) and Patrick Sandra (UGent)
(2018) LC GC EUROPE. 31(2). p.82-89
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Organization
Abstract
Chromatographic method development for pharmaceutical analysis can benefit from in silico steered serial coupling of column segments containing different stationary phases of varying length. Contrary to column coupling through trial and error, in stationary-phase optimized selectivity (SOS)-based chromatography the retention of all solutes is predicted for all possible column combinations allowing a rational selection of the optimal column combination. The possibilities of the strategy now surpass the initial usage in isocratic high performance liquid chromatography (HPLC) on dedicated commercial column segments, and allow applications in gradient-, green-, preparative-, and in supercritical fluid chromatography (SFC) on conventional column hardware. Current possibilities, pharmaceutical applications, a downloadable algorithm, and weaknesses of the approach are discussed to allow broader implementation of this methodology in separation science.
Keywords
GRADIENT ELUTION, SEPARATION, BEHAVIOR, COLUMNS

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Citation

Please use this url to cite or link to this publication:

MLA
Lynen, Frederic et al. “Stationary-phase Optimized Selectivity in Liquid Chromatography (SOS-LC) for Pharmaceutical Analysis.” LC GC EUROPE 31.2 (2018): 82–89. Print.
APA
Lynen, F., Hegade, R. S., De Beer, M., Chen, K., Delahaye, S., & Sandra, P. (2018). Stationary-phase optimized selectivity in liquid chromatography (SOS-LC) for pharmaceutical analysis. LC GC EUROPE, 31(2), 82–89.
Chicago author-date
Lynen, Frederic, Ravindra Suryakant Hegade, Maarten De Beer, Kai Chen, Sander Delahaye, and Patrick Sandra. 2018. “Stationary-phase Optimized Selectivity in Liquid Chromatography (SOS-LC) for Pharmaceutical Analysis.” Lc Gc Europe 31 (2): 82–89.
Chicago author-date (all authors)
Lynen, Frederic, Ravindra Suryakant Hegade, Maarten De Beer, Kai Chen, Sander Delahaye, and Patrick Sandra. 2018. “Stationary-phase Optimized Selectivity in Liquid Chromatography (SOS-LC) for Pharmaceutical Analysis.” Lc Gc Europe 31 (2): 82–89.
Vancouver
1.
Lynen F, Hegade RS, De Beer M, Chen K, Delahaye S, Sandra P. Stationary-phase optimized selectivity in liquid chromatography (SOS-LC) for pharmaceutical analysis. LC GC EUROPE. 2018;31(2):82–9.
IEEE
[1]
F. Lynen, R. S. Hegade, M. De Beer, K. Chen, S. Delahaye, and P. Sandra, “Stationary-phase optimized selectivity in liquid chromatography (SOS-LC) for pharmaceutical analysis,” LC GC EUROPE, vol. 31, no. 2, pp. 82–89, 2018.
@article{8599671,
  abstract     = {Chromatographic method development for pharmaceutical analysis can benefit from in silico steered serial coupling of column segments containing different stationary phases of varying length. Contrary to column coupling through trial and error, in stationary-phase optimized selectivity (SOS)-based chromatography the retention of all solutes is predicted for all possible column combinations allowing a rational selection of the optimal column combination. The possibilities of the strategy now surpass the initial usage in isocratic high performance liquid chromatography (HPLC) on dedicated commercial column segments, and allow applications in gradient-, green-, preparative-, and in supercritical fluid chromatography (SFC) on conventional column hardware. Current possibilities, pharmaceutical applications, a downloadable algorithm, and weaknesses of the approach are discussed to allow broader implementation of this methodology in separation science.},
  author       = {Lynen, Frederic and Hegade, Ravindra Suryakant and De Beer, Maarten and Chen, Kai and Delahaye, Sander and Sandra, Patrick},
  issn         = {1471-6577},
  journal      = {LC GC EUROPE},
  keywords     = {GRADIENT ELUTION,SEPARATION,BEHAVIOR,COLUMNS},
  language     = {eng},
  number       = {2},
  pages        = {82--89},
  title        = {Stationary-phase optimized selectivity in liquid chromatography (SOS-LC) for pharmaceutical analysis},
  volume       = {31},
  year         = {2018},
}

Web of Science
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