Advanced search
1 file | 4.98 MB

Bifunctionalized redox-responsive layers prepared from a thiolactone copolymer

(2018) LANGMUIR. 34(18). p.5234-5244
Author
Organization
Abstract
The development of multifunctional surfaces is of general interest for the fabrication of biomedical, catalytic, microfluidic or biosensing devices. Herein, we report on the preparation of copolymer layers immobilized on gold surface and showing both free thiol and amino groups. These layers are produced by aminolysis of a thiolactone-based copolymer in the presence of a diamine, according to a one-step procedure. The free thiol and amino groups present in the modified copolymer layers can be successfully functionalized with respectively thiolated and carboxylic derivatives, in order to produce bifunctionalized surfaces. In addition, we show that the grafted thiolated derivative can be released by cleavage of the disulfide bond under mild reducing conditions. On the other hand, a side cross-linking reaction occurring during the grafting process and resulting in the formation of copolymer aggregates on the metal surface is evidenced. The methodology developed for the preparation of these bifunctionalized redox-responsive layers should be advantageously used to produce bioactive surfaces with drug loading/release properties.
Keywords
SELF-ASSEMBLED MONOLAYERS, IMPEDANCE SPECTROSCOPY, ENZYME, IMMOBILIZATION, CELL-ADHESION, GOLD, BIOMATERIALS, PEPTIDES, SURFACES, TOOL, ANTIBACTERIAL

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 4.98 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Chattaway, Claire, Sabrina Belbekhouche, Filip Du Prez, Karine Glinel, and Sophie Demoustier-Champagne. 2018. “Bifunctionalized Redox-responsive Layers Prepared from a Thiolactone Copolymer.” Langmuir 34 (18): 5234–5244.
APA
Chattaway, C., Belbekhouche, S., Du Prez, F., Glinel, K., & Demoustier-Champagne, S. (2018). Bifunctionalized redox-responsive layers prepared from a thiolactone copolymer. LANGMUIR, 34(18), 5234–5244.
Vancouver
1.
Chattaway C, Belbekhouche S, Du Prez F, Glinel K, Demoustier-Champagne S. Bifunctionalized redox-responsive layers prepared from a thiolactone copolymer. LANGMUIR. 2018;34(18):5234–44.
MLA
Chattaway, Claire et al. “Bifunctionalized Redox-responsive Layers Prepared from a Thiolactone Copolymer.” LANGMUIR 34.18 (2018): 5234–5244. Print.
@article{8599619,
  abstract     = {The development of multifunctional surfaces is of general interest for the fabrication of biomedical, catalytic, microfluidic or biosensing devices. Herein, we report on the preparation of copolymer layers immobilized on gold surface and showing both free thiol and amino groups. These layers are produced by aminolysis of a thiolactone-based copolymer in the presence of a diamine, according to a one-step procedure. The free thiol and amino groups present in the modified copolymer layers can be successfully functionalized with respectively thiolated and carboxylic derivatives, in order to produce bifunctionalized surfaces. In addition, we show that the grafted thiolated derivative can be released by cleavage of the disulfide bond under mild reducing conditions. On the other hand, a side cross-linking reaction occurring during the grafting process and resulting in the formation of copolymer aggregates on the metal surface is evidenced. The methodology developed for the preparation of these bifunctionalized redox-responsive layers should be advantageously used to produce bioactive surfaces with drug loading/release properties.},
  author       = {Chattaway, Claire and Belbekhouche, Sabrina and Du Prez, Filip and Glinel, Karine and Demoustier-Champagne, Sophie},
  issn         = {0743-7463},
  journal      = {LANGMUIR},
  language     = {eng},
  number       = {18},
  pages        = {5234--5244},
  title        = {Bifunctionalized redox-responsive layers prepared from a thiolactone copolymer},
  url          = {http://dx.doi.org/10.1021/acs.langmuir.8b00525},
  volume       = {34},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: