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The path toward PET-guided radiation therapy for glioblastoma in laboratory animals : a mini review

Sam Donche (UGent) , Jeroen Verhoeven (UGent) , Benedicte Descamps (UGent) , Julie Bolcaen (UGent) , Karel Deblaere (UGent) , Tom Boterberg (UGent) , Caroline Van den Broecke (UGent) , Christian Vanhove (UGent) and Ingeborg Goethals (UGent)
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Abstract
Glioblastoma is the most aggressive and malignant primary brain tumor in adults. Despite the current state-of-the-art treatment, which consists of maximal surgical resection followed by radiation therapy, concomitant, and adjuvant chemotherapy, progression remains rapid due to aggressive tumor characteristics. Several new therapeutic targets have been investigated using chemotherapeutics and targeted molecular drugs, however, the intrinsic resistance to induced cell death of brain cells impede the effectiveness of systemic therapies. Also, the unique immune environment of the central nervous system imposes challenges for immune-based therapeutics. Therefore, it is important to consider other approaches to treat these tumors. There is a well-known dose-response relationship for glioblastoma with increased survival with increasing doses, but this effect seems to cap around 60Gy, due to increased toxicity to the normal brain. Currently, radiation treatment planning of glioblastoma patients relies on CT and MRI that does not visualize the heterogeneous nature of the tumor, and consequently, a homogenous dose is delivered to the entire tumor. Metabolic imaging, such as positron-emission tomography, allows to visualize the heterogeneous tumor environment. Using these metabolic imaging techniques, an approach called dose painting can be used to deliver a higher dose to the tumor regions with high malignancy and/or radiation resistance. Preclinical studies are required for evaluating the bene fits of novel radiation treatment strategies, such as PET-based dose painting. The aim of this review is to give a brief overview of promising PET tracers that can be evaluated in laboratory animals to bridge the gap between PET-based dose painting in glioblastoma patients.
Keywords
PET, radiation therapy, laboratory animals, dose painting, glioblastoma, tumor heterogeneity, POSITRON-EMISSION-TOMOGRAPHY, INTEGRATED X-RAY, BRAIN-TUMOR EXTENT, HIGH-GRADE GLIOMAS, AMINO-ACID PET, RESPONSE ASSESSMENT, O-(2-F-18-FLUOROETHYL)-L-TYROSINE PET, COMPUTED-TOMOGRAPHY, MALIGNANT GLIOMA, RADIOTHERAPY

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Chicago
Donche, Sam, Jeroen Verhoeven, Benedicte Descamps, Julie Bolcaen, Karel Deblaere, Tom Boterberg, Caroline Van den Broecke, Christian Vanhove, and Ingeborg Goethals. 2019. “The Path Toward PET-guided Radiation Therapy for Glioblastoma in Laboratory Animals : a Mini Review.” Frontiers in Medicine 6.
APA
Donche, S., Verhoeven, J., Descamps, B., Bolcaen, J., Deblaere, K., Boterberg, T., Van den Broecke, C., et al. (2019). The path toward PET-guided radiation therapy for glioblastoma in laboratory animals : a mini review. FRONTIERS IN MEDICINE, 6.
Vancouver
1.
Donche S, Verhoeven J, Descamps B, Bolcaen J, Deblaere K, Boterberg T, et al. The path toward PET-guided radiation therapy for glioblastoma in laboratory animals : a mini review. FRONTIERS IN MEDICINE. 2019;6.
MLA
Donche, Sam et al. “The Path Toward PET-guided Radiation Therapy for Glioblastoma in Laboratory Animals : a Mini Review.” FRONTIERS IN MEDICINE 6 (2019): n. pag. Print.
@article{8599582,
  abstract     = {Glioblastoma is the most aggressive and malignant primary brain tumor in adults. Despite the current state-of-the-art treatment, which consists of maximal surgical resection followed by radiation therapy, concomitant, and adjuvant chemotherapy, progression remains rapid due to aggressive tumor characteristics. Several new therapeutic targets have been investigated using chemotherapeutics and targeted molecular drugs, however, the intrinsic resistance to induced cell death of brain cells impede the effectiveness of systemic therapies. Also, the unique immune environment of the central nervous system imposes challenges for immune-based therapeutics. Therefore, it is important to consider other approaches to treat these tumors. There is a well-known dose-response relationship for glioblastoma with increased survival with increasing doses, but this effect seems to cap around 60Gy, due to increased toxicity to the normal brain. Currently, radiation treatment planning of glioblastoma patients relies on CT and MRI that does not visualize the heterogeneous nature of the tumor, and consequently, a homogenous dose is delivered to the entire tumor. Metabolic imaging, such as positron-emission tomography, allows to visualize the heterogeneous tumor environment. Using these metabolic imaging techniques, an approach called dose painting can be used to deliver a higher dose to the tumor regions with high malignancy and/or radiation resistance. Preclinical studies are required for evaluating the bene fits of novel radiation treatment strategies, such as PET-based dose painting. The aim of this review is to give a brief overview of promising PET tracers that can be evaluated in laboratory animals to bridge the gap between PET-based dose painting in glioblastoma patients.},
  articleno    = {5},
  author       = {Donche, Sam and Verhoeven, Jeroen and Descamps, Benedicte and Bolcaen, Julie and Deblaere, Karel and Boterberg, Tom and Van den Broecke, Caroline and Vanhove, Christian and Goethals, Ingeborg},
  issn         = {2296-858X},
  journal      = {FRONTIERS IN MEDICINE},
  language     = {eng},
  pages        = {9},
  title        = {The path toward PET-guided radiation therapy for glioblastoma in laboratory animals : a mini review},
  url          = {http://dx.doi.org/10.3389/fmed.2019.00005},
  volume       = {6},
  year         = {2019},
}

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