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Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement

Gabriela Rentería Gámiz (UGent) , Pieter-Jan Van Bockstal (UGent) , Steven De Meester (UGent) , Thomas De Beer (UGent) , Jos Corver (UGent) and Jo Dewulf (UGent)
(2019) DRYING TECHNOLOGY. 37(13). p.1563-1582
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Abstract
Whilst freeze drying is known by its high energy requirements, few studies have been conducted assessing the efficiency of freeze dryers, specially related pharmaceuticals. A quantitative analysis is conducted on a batch freeze dryer used for biopharmaceuticals, aiming to know the process efficiency and to identify the components having the highest resource consumption as well as factors for potential improvement. Exergy and energy analysis were done combining experimental and modeled data. The process showed a task efficiency lower than 1%. This value is influenced by the low coefficient of performance of the refrigeration cycle as well as the large mass of steal in the device which is heated up and cooled down throughout the process.
Keywords
Freeze drying, efficiency, thermodynamics, biopharmaceuticals, HEAT-TRANSFER, EXERGY ANALYSIS, DRYING CYCLE, DESIGN SPACE, MODEL, OPTIMIZATION, COEFFICIENTS, MORPHOLOGY, STORAGE, VIALS

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MLA
Rentería Gámiz, Gabriela et al. “Analysis of a Pharmaceutical Batch Freeze Dryer : Resource Consumption, Hotspots, and Factors for Potential Improvement.” DRYING TECHNOLOGY 37.13 (2019): 1563–1582. Print.
APA
Rentería Gámiz, G., Van Bockstal, P.-J., De Meester, S., De Beer, T., Corver, J., & Dewulf, J. (2019). Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement. DRYING TECHNOLOGY, 37(13), 1563–1582.
Chicago author-date
Rentería Gámiz, Gabriela, Pieter-Jan Van Bockstal, Steven De Meester, Thomas De Beer, Jos Corver, and Jo Dewulf. 2019. “Analysis of a Pharmaceutical Batch Freeze Dryer : Resource Consumption, Hotspots, and Factors for Potential Improvement.” Drying Technology 37 (13): 1563–1582.
Chicago author-date (all authors)
Rentería Gámiz, Gabriela, Pieter-Jan Van Bockstal, Steven De Meester, Thomas De Beer, Jos Corver, and Jo Dewulf. 2019. “Analysis of a Pharmaceutical Batch Freeze Dryer : Resource Consumption, Hotspots, and Factors for Potential Improvement.” Drying Technology 37 (13): 1563–1582.
Vancouver
1.
Rentería Gámiz G, Van Bockstal P-J, De Meester S, De Beer T, Corver J, Dewulf J. Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement. DRYING TECHNOLOGY. 2019;37(13):1563–82.
IEEE
[1]
G. Rentería Gámiz, P.-J. Van Bockstal, S. De Meester, T. De Beer, J. Corver, and J. Dewulf, “Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement,” DRYING TECHNOLOGY, vol. 37, no. 13, pp. 1563–1582, 2019.
@article{8599117,
  abstract     = {Whilst freeze drying is known by its high energy requirements, few studies have been conducted assessing the efficiency of freeze dryers, specially related pharmaceuticals. A quantitative analysis is conducted on a batch freeze dryer used for biopharmaceuticals, aiming to know the process efficiency and to identify the components having the highest resource consumption as well as factors for potential improvement. Exergy and energy analysis were done combining experimental and modeled data. The process showed a task efficiency lower than 1%. This value is influenced by the low coefficient of performance of the refrigeration cycle as well as the large mass of steal in the device which is heated up and cooled down throughout the process.},
  author       = {Rentería Gámiz, Gabriela and Van Bockstal, Pieter-Jan and De Meester, Steven and De Beer, Thomas and Corver, Jos and Dewulf, Jo},
  issn         = {0737-3937},
  journal      = {DRYING TECHNOLOGY},
  keywords     = {Freeze drying,efficiency,thermodynamics,biopharmaceuticals,HEAT-TRANSFER,EXERGY ANALYSIS,DRYING CYCLE,DESIGN SPACE,MODEL,OPTIMIZATION,COEFFICIENTS,MORPHOLOGY,STORAGE,VIALS},
  language     = {eng},
  number       = {13},
  pages        = {1563--1582},
  title        = {Analysis of a pharmaceutical batch freeze dryer : resource consumption, hotspots, and factors for potential improvement},
  url          = {http://dx.doi.org/10.1080/07373937.2018.1518916},
  volume       = {37},
  year         = {2019},
}

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