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Combined effect of Laponite and polymer molecular weight on the cell-interactive properties of synthetic PEO-based hydrogels

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Abstract
Varying physico-chemical properties of synthetic hydrogels and introducing additives can induce a cell interactive response of hydrogels. Hydrogels were developed based on acrylate-endcapped urethane-based poly (ethylene glycol) precursors with varying backbone molecular weight (2000-8000 g/mol), in combination with the nanoclay Laponite to explore effects on swelling, mechanical and in vitro biological properties. The combined effect of molecular weight and Laponite concentration enables the development of hybrid materials useful for different biomedical applications. Gel fractions approximating 100% along with tunable swelling (4-11 g/g polymer) and mechanical properties (Young's Modulus 0.1-0.6 MPa) are obtained. All materials are non-cytotoxic and AUPs without Laponite are non cell-interative rendering them suitable for non-adherent biomedical applications. Hydrogels composed of Laponite (0.5 or 1 wt%) and PEG backbone molecular weight of 2000 g/ mol promote cell proliferation useful to function as synthetic dermal matrices or scaffolds for tissue engineering applications.
Keywords
PEG based, Nanoclay Laponite, Tunable, Mechanical properties, Cell tests, ACELLULAR DERMAL MATRIX, DRUG-DELIVERY, CROSS-LINKING, IN-VITRO, BIOMECHANICAL PROPERTIES, SUPERABSORBENT HYDROGEL, NANOCOMPOSITE HYDROGELS, BIOMEDICAL APPLICATIONS, MECHANICAL-PROPERTIES, GELATIN

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MLA
Mignon, Arn, et al. “Combined Effect of Laponite and Polymer Molecular Weight on the Cell-Interactive Properties of Synthetic PEO-Based Hydrogels.” REACTIVE & FUNCTIONAL POLYMERS, vol. 136, 2019, pp. 95–106.
APA
Mignon, A., Pezzoli, D., Prouvé, E., Lévesque, L., Arslan, A., Pien, N., … Dubruel, P. (2019). Combined effect of Laponite and polymer molecular weight on the cell-interactive properties of synthetic PEO-based hydrogels. REACTIVE & FUNCTIONAL POLYMERS, 136, 95–106.
Chicago author-date
Mignon, Arn, Daniele Pezzoli, Emilie Prouvé, Lucie Lévesque, Aysu Arslan, Nele Pien, David Schaubroeck, et al. 2019. “Combined Effect of Laponite and Polymer Molecular Weight on the Cell-Interactive Properties of Synthetic PEO-Based Hydrogels.” REACTIVE & FUNCTIONAL POLYMERS 136: 95–106.
Chicago author-date (all authors)
Mignon, Arn, Daniele Pezzoli, Emilie Prouvé, Lucie Lévesque, Aysu Arslan, Nele Pien, David Schaubroeck, Jasper Van Hoorick, Diego Mantovani, Sandra Van Vlierberghe, and Peter Dubruel. 2019. “Combined Effect of Laponite and Polymer Molecular Weight on the Cell-Interactive Properties of Synthetic PEO-Based Hydrogels.” REACTIVE & FUNCTIONAL POLYMERS 136: 95–106.
Vancouver
1.
Mignon A, Pezzoli D, Prouvé E, Lévesque L, Arslan A, Pien N, et al. Combined effect of Laponite and polymer molecular weight on the cell-interactive properties of synthetic PEO-based hydrogels. REACTIVE & FUNCTIONAL POLYMERS. 2019;136:95–106.
IEEE
[1]
A. Mignon et al., “Combined effect of Laponite and polymer molecular weight on the cell-interactive properties of synthetic PEO-based hydrogels,” REACTIVE & FUNCTIONAL POLYMERS, vol. 136, pp. 95–106, 2019.
@article{8599035,
  abstract     = {Varying physico-chemical properties of synthetic hydrogels and introducing additives can induce a cell interactive response of hydrogels. Hydrogels were developed based on acrylate-endcapped urethane-based poly (ethylene glycol) precursors with varying backbone molecular weight (2000-8000 g/mol), in combination with the nanoclay Laponite to explore effects on swelling, mechanical and in vitro biological properties. The combined effect of molecular weight and Laponite concentration enables the development of hybrid materials useful for different biomedical applications. Gel fractions approximating 100% along with tunable swelling (4-11 g/g polymer) and mechanical properties (Young's Modulus 0.1-0.6 MPa) are obtained. All materials are non-cytotoxic and AUPs without Laponite are non cell-interative rendering them suitable for non-adherent biomedical applications. Hydrogels composed of Laponite (0.5 or 1 wt%) and PEG backbone molecular weight of 2000 g/ mol promote cell proliferation useful to function as synthetic dermal matrices or scaffolds for tissue engineering applications.},
  author       = {Mignon, Arn and Pezzoli, Daniele and Prouvé, Emilie and Lévesque, Lucie and Arslan, Aysu and Pien, Nele and Schaubroeck, David and Van Hoorick, Jasper and Mantovani, Diego and Van Vlierberghe, Sandra and Dubruel, Peter},
  issn         = {1381-5148},
  journal      = {REACTIVE & FUNCTIONAL POLYMERS},
  keywords     = {PEG based,Nanoclay Laponite,Tunable,Mechanical properties,Cell tests,ACELLULAR DERMAL MATRIX,DRUG-DELIVERY,CROSS-LINKING,IN-VITRO,BIOMECHANICAL PROPERTIES,SUPERABSORBENT HYDROGEL,NANOCOMPOSITE HYDROGELS,BIOMEDICAL APPLICATIONS,MECHANICAL-PROPERTIES,GELATIN},
  language     = {eng},
  pages        = {95--106},
  title        = {Combined effect of Laponite and polymer molecular weight on the cell-interactive properties of synthetic PEO-based hydrogels},
  url          = {http://dx.doi.org/10.1016/j.reactfunctpolym.2018.12.017},
  volume       = {136},
  year         = {2019},
}

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