Advanced search
1 file | 3.58 MB Add to list

Genes at the crossroad of primary immunodeficiencies and cancer

Author
Organization
Abstract
Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited disorders affecting one or multiple components of the innate and/or adaptive immune system. Currently, over 300 underlying genetic defects have been discovered. The most common clinical findings in patients with PIDs are infections, autoimmunity, and malignancies. Despite international efforts, the cancer risk associated with PIDs, given the heterogeneous character of this group of diseases, is difficult to estimate. The diverse underlying mechanisms of cancer in PID add another layer of complexity. Treatment of cancer within a context of PID is complicated by serious toxicities and long-term effects, including second malignancies. This review will focus on the little-known crossroad between PID and cancer genes and the value thereof for directing future research on our understanding of cancer in PID and for the identification of early cancer biomarkers in PID patients.
Keywords
ACUTE LYMPHOBLASTIC-LEUKEMIA, B-CELL LYMPHOMA, ATAXIA-TELANGIECTASIA, PREDISPOSITION GENES, INTERNATIONAL UNION, IMMUNE SURVEILLANCE, AUTOSOMAL-DOMINANT, MONOMAC SYNDROME, INBORN-ERRORS, MUTATIONS, primary immunodeficiency, cancer, predisposition, genetics, biomarkers

Downloads

  • fimmu-09-02544.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 3.58 MB

Citation

Please use this url to cite or link to this publication:

MLA
Derpoorter, Charlotte, et al. “Genes at the Crossroad of Primary Immunodeficiencies and Cancer.” FRONTIERS IN IMMUNOLOGY, vol. 9, 2018, doi:10.3389/fimmu.2018.02544.
APA
Derpoorter, C., Bordon Cueto De Braem, M., Laureys, G., Haerynck, F., & Lammens, T. (2018). Genes at the crossroad of primary immunodeficiencies and cancer. FRONTIERS IN IMMUNOLOGY, 9. https://doi.org/10.3389/fimmu.2018.02544
Chicago author-date
Derpoorter, Charlotte, Maria Bordon Cueto De Braem, Genevieve Laureys, Filomeen Haerynck, and Tim Lammens. 2018. “Genes at the Crossroad of Primary Immunodeficiencies and Cancer.” FRONTIERS IN IMMUNOLOGY 9. https://doi.org/10.3389/fimmu.2018.02544.
Chicago author-date (all authors)
Derpoorter, Charlotte, Maria Bordon Cueto De Braem, Genevieve Laureys, Filomeen Haerynck, and Tim Lammens. 2018. “Genes at the Crossroad of Primary Immunodeficiencies and Cancer.” FRONTIERS IN IMMUNOLOGY 9. doi:10.3389/fimmu.2018.02544.
Vancouver
1.
Derpoorter C, Bordon Cueto De Braem M, Laureys G, Haerynck F, Lammens T. Genes at the crossroad of primary immunodeficiencies and cancer. FRONTIERS IN IMMUNOLOGY. 2018;9.
IEEE
[1]
C. Derpoorter, M. Bordon Cueto De Braem, G. Laureys, F. Haerynck, and T. Lammens, “Genes at the crossroad of primary immunodeficiencies and cancer,” FRONTIERS IN IMMUNOLOGY, vol. 9, 2018.
@article{8599011,
  abstract     = {Primary immunodeficiencies (PIDs) are a heterogeneous group of inherited disorders affecting one or multiple components of the innate and/or adaptive immune system. Currently, over 300 underlying genetic defects have been discovered. The most common clinical findings in patients with PIDs are infections, autoimmunity, and malignancies. Despite international efforts, the cancer risk associated with PIDs, given the heterogeneous character of this group of diseases, is difficult to estimate. The diverse underlying mechanisms of cancer in PID add another layer of complexity. Treatment of cancer within a context of PID is complicated by serious toxicities and long-term effects, including second malignancies. This review will focus on the little-known crossroad between PID and cancer genes and the value thereof for directing future research on our understanding of cancer in PID and for the identification of early cancer biomarkers in PID patients.},
  articleno    = {2544},
  author       = {Derpoorter, Charlotte and Bordon Cueto De Braem, Maria and Laureys, Genevieve and Haerynck, Filomeen and Lammens, Tim},
  issn         = {1664-3224},
  journal      = {FRONTIERS IN IMMUNOLOGY},
  keywords     = {ACUTE LYMPHOBLASTIC-LEUKEMIA,B-CELL LYMPHOMA,ATAXIA-TELANGIECTASIA,PREDISPOSITION GENES,INTERNATIONAL UNION,IMMUNE SURVEILLANCE,AUTOSOMAL-DOMINANT,MONOMAC SYNDROME,INBORN-ERRORS,MUTATIONS,primary immunodeficiency,cancer,predisposition,genetics,biomarkers},
  language     = {eng},
  pages        = {7},
  title        = {Genes at the crossroad of primary immunodeficiencies and cancer},
  url          = {http://dx.doi.org/10.3389/fimmu.2018.02544},
  volume       = {9},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: