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Bypassing border control : nuclear envelope rupture in disease

(2018) PHYSIOLOGY. 33(1). p.39-49
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Abstract
Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.
Keywords
CYTOSOLIC DNA SENSOR, LAMIN-A/C, ESCRT-III, STRUCTURAL ORGANIZATION, NUCLEOPLASMIC RETICULUM, IMMUNE RECOGNITION, OXIDATIVE STRESS, CELL-MIGRATION, SOMATIC-CELLS, LINC COMPLEX

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Citation

Please use this url to cite or link to this publication:

Chicago
Houthaeve, Gaëlle, Joke Robijns, Kevin Braeckmans, and Winnok De Vos. 2018. “Bypassing Border Control : Nuclear Envelope Rupture in Disease.” Physiology 33 (1): 39–49.
APA
Houthaeve, G., Robijns, J., Braeckmans, K., & De Vos, W. (2018). Bypassing border control : nuclear envelope rupture in disease. PHYSIOLOGY, 33(1), 39–49.
Vancouver
1.
Houthaeve G, Robijns J, Braeckmans K, De Vos W. Bypassing border control : nuclear envelope rupture in disease. PHYSIOLOGY. 2018;33(1):39–49.
MLA
Houthaeve, Gaëlle et al. “Bypassing Border Control : Nuclear Envelope Rupture in Disease.” PHYSIOLOGY 33.1 (2018): 39–49. Print.
@article{8598965,
  abstract     = {Recent observations in laminopathy patient cells and cancer cells have revealed that the nuclear envelope (NE) can transiently rupture during interphase. NE rupture leads to an uncoordinated exchange of nuclear and cytoplasmic material, thereby deregulating cellular homeostasis. Moreover, concurrently inflicted DNA damage could prime rupture-prone cells for genome instability. Thus, NE rupture may represent a novel pathogenic mechanism that has far-reaching consequences for cell and organism physiology.},
  author       = {Houthaeve, Ga{\"e}lle and Robijns, Joke and Braeckmans, Kevin and De Vos, Winnok},
  issn         = {1548-9213},
  journal      = {PHYSIOLOGY},
  language     = {eng},
  number       = {1},
  pages        = {39--49},
  title        = {Bypassing border control : nuclear envelope rupture in disease},
  url          = {http://dx.doi.org/10.1152/physiol.00029.2017},
  volume       = {33},
  year         = {2018},
}

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