Academic Bibliography

 Search 200 years of publications by Ghent University researchers.
Advanced search
1 file | 2.27 MB
Add to list
  1. Search results
  2. Marine biogenics in sea spray aerosol...

Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway

Jana Asselman (UGent) , Emmanuel Van Acker (UGent) , Maarten De Rijcke, Laurentijn Tilleman (UGent) , Filip Van Nieuwerburgh (UGent) , Jan Mees (UGent) , Karel De Schamphelaere (UGent) and Colin Janssen (UGent)
(2019) SCIENTIFIC REPORTS. 9.
Author
Organization
Abstract
Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway and of PCSK9 after exposure to the natural SSA and the mTOR inhibitor, suggesting induction of apoptosis. Our results indicate that marine biogenics in SSAs interact with PCSK9 and the mTOR pathway and can be used in new potential pharmaceutical applications. Overall, our results provide a substantial molecular evidence base for potential beneficial health effects at environmentally relevant concentrations of natural SSAs.
Keywords
HARMFUL ALGAL BLOOMS, HUMAN HEALTH, DIFFERENTIAL EXPRESSION, BIOCONDUCTOR PACKAGE, ARCTIC-OCEAN, SYSTEM, TOXINS, CELLS, WELL, BREVETOXINS

Downloads

  • Download
    2019 Asselman et al Sci Reports.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 2.27 MB

Citation

Please use this url to cite or link to this publication:

MLA
Asselman, Jana et al. “Marine Biogenics in Sea Spray Aerosols Interact with the mTOR Signaling Pathway.” SCIENTIFIC REPORTS 9 (2019): n. pag. Print.
APA
Asselman, J., Van Acker, E., De Rijcke, M., Tilleman, L., Van Nieuwerburgh, F., Mees, J., De Schamphelaere, K., et al. (2019). Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. SCIENTIFIC REPORTS, 9.
Chicago author-date
Asselman, Jana, Emmanuel Van Acker, Maarten De Rijcke, Laurentijn Tilleman, Filip Van Nieuwerburgh, Jan Mees, Karel De Schamphelaere, and Colin Janssen. 2019. “Marine Biogenics in Sea Spray Aerosols Interact with the mTOR Signaling Pathway.” Scientific Reports 9.
Chicago author-date (all authors)
Asselman, Jana, Emmanuel Van Acker, Maarten De Rijcke, Laurentijn Tilleman, Filip Van Nieuwerburgh, Jan Mees, Karel De Schamphelaere, and Colin Janssen. 2019. “Marine Biogenics in Sea Spray Aerosols Interact with the mTOR Signaling Pathway.” Scientific Reports 9.
Vancouver
1.
Asselman J, Van Acker E, De Rijcke M, Tilleman L, Van Nieuwerburgh F, Mees J, et al. Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway. SCIENTIFIC REPORTS. 2019;9.
IEEE
[1]
J. Asselman et al., “Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway,” SCIENTIFIC REPORTS, vol. 9, 2019.
@article{8594007,
  abstract     = {Sea spray aerosols (SSAs) have profound effects on our climate and ecosystems. They also contain microbiota and biogenic molecules which could affect human health. Yet the exposure and effects of SSAs on human health remain poorly studied. Here, we exposed human lung cancer cells to extracts of a natural sea spray aerosol collected at the seashore in Belgium, a laboratory-generated SSA, the marine algal toxin homoyessotoxin and a chemical inhibitor of the mammalian target of rapamycin (mTOR) pathway. We observed significant increased expression of genes related to the mTOR pathway and Proprotein convertase subtilisin/kexin type 9 (PCSK9) after exposure to homoyessotoxin and the laboratory-generated SSA. In contrast, we observed a significant decrease in gene expression in the mTOR pathway and of PCSK9 after exposure to the natural SSA and the mTOR inhibitor, suggesting induction of apoptosis. Our results indicate that marine biogenics in SSAs interact with PCSK9 and the mTOR pathway and can be used in new potential pharmaceutical applications. Overall, our results provide a substantial molecular evidence base for potential beneficial health effects at environmentally relevant concentrations of natural SSAs.},
  articleno    = {675},
  author       = {Asselman, Jana and Van Acker, Emmanuel and De Rijcke, Maarten and Tilleman, Laurentijn and Van Nieuwerburgh, Filip and Mees, Jan and De Schamphelaere, Karel and Janssen, Colin},
  issn         = {2045-2322},
  journal      = {SCIENTIFIC REPORTS},
  keywords     = {HARMFUL ALGAL BLOOMS,HUMAN HEALTH,DIFFERENTIAL EXPRESSION,BIOCONDUCTOR PACKAGE,ARCTIC-OCEAN,SYSTEM,TOXINS,CELLS,WELL,BREVETOXINS},
  language     = {eng},
  pages        = {10},
  title        = {Marine biogenics in sea spray aerosols interact with the mTOR signaling pathway},
  url          = {http://dx.doi.org/10.1038/s41598-018-36866-3},
  volume       = {9},
  year         = {2019},
}
Altmetric
View in Altmetric
Web of Science
Times cited: