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Treatment of a malignant peripheral nerve sheath tumor by intravenous administration of combretastatin A4-phosphate in a dog

Shana De Vos (UGent) , Eline Abma (UGent) , Katrien Vanderperren (UGent) , Leen Van Brantegem (UGent) , Ward De Spiegelaere (UGent) and Hilde De Rooster (UGent)
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Abstract
A fifteen-year-old, male, castrated American Staffordshire terrier was presented with a subcutaneous, ulcerated mass on the right carpal joint. Thoracic radiographs and abdominal ultrasound were both negative for metastatic disease. Punch biopsies revealed the histopathological diagnosis of a malignant peripheral nerve sheath tumor. Due to the extent of the primary mass, local excision was not possible, and amputation of the limb was not an option for the owner. The dog was treated with intravenous administration of combretastatin A4-phosphate, a vascular disrupting agent. A biopsy was taken before and after treatment and power-Doppler ultrasound and contrast-enhanced ultrasound were performed to assess pre- and posttreatment evaluation of the tumor vasculature. The treatment resulted in massive necrosis of the tumor.
Keywords
A4 PHOSPHATE, ULTRASOUND, TRIAL, DOXORUBICIN, SCHEDULE, CANCER

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Chicago
De Vos, Shana, Eline Abma, Katrien Vanderperren, Leen Van Brantegem, Ward De Spiegelaere, and Hilde De Rooster. 2018. “Treatment of a Malignant Peripheral Nerve Sheath Tumor by Intravenous Administration of Combretastatin A4-phosphate in a Dog.” Vlaams Diergeneeskundig Tijdschrift 87 (6): 326–332.
APA
De Vos, S., Abma, E., Vanderperren, K., Van Brantegem, L., De Spiegelaere, W., & De Rooster, H. (2018). Treatment of a malignant peripheral nerve sheath tumor by intravenous administration of combretastatin A4-phosphate in a dog. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT, 87(6), 326–332.
Vancouver
1.
De Vos S, Abma E, Vanderperren K, Van Brantegem L, De Spiegelaere W, De Rooster H. Treatment of a malignant peripheral nerve sheath tumor by intravenous administration of combretastatin A4-phosphate in a dog. VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT. 2018;87(6):326–32.
MLA
De Vos, Shana et al. “Treatment of a Malignant Peripheral Nerve Sheath Tumor by Intravenous Administration of Combretastatin A4-phosphate in a Dog.” VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT 87.6 (2018): 326–332. Print.
@article{8593888,
  abstract     = {A fifteen-year-old, male, castrated American Staffordshire terrier was presented with a subcutaneous, ulcerated mass on the right carpal joint. Thoracic radiographs and abdominal ultrasound were both negative for metastatic disease. Punch biopsies revealed the histopathological diagnosis of a malignant peripheral nerve sheath tumor. Due to the extent of the primary mass, local excision was not possible, and amputation of the limb was not an option for the owner. The dog was treated with intravenous administration of combretastatin A4-phosphate, a vascular disrupting agent. A biopsy was taken before and after treatment and power-Doppler ultrasound and contrast-enhanced ultrasound were performed to assess pre- and posttreatment evaluation of the tumor vasculature. The treatment resulted in massive necrosis of the tumor.},
  author       = {De Vos, Shana and Abma, Eline and Vanderperren, Katrien and Van Brantegem, Leen and De Spiegelaere, Ward and De Rooster, Hilde},
  issn         = {0303-9021},
  journal      = {VLAAMS DIERGENEESKUNDIG TIJDSCHRIFT},
  language     = {eng},
  number       = {6},
  pages        = {326--332},
  title        = {Treatment of a malignant peripheral nerve sheath tumor by intravenous administration of combretastatin A4-phosphate in a dog},
  volume       = {87},
  year         = {2018},
}

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