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Connexin and pannexin (hemi)channels : emerging targets in the treatment of liver disease

(2019) HEPATOLOGY. 69(3). p.1317-1323
Author
Organization
Abstract
Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle. In the last decade, it has become clear that connexin hemichannels also provide a pathway for cellular communication on their own independent of their role as structural precursors of gap junctions, namely between the cytosol of an individual cell and its extracellular environment. In contrast to gap junctions, connexin hemichannels become particularly active in liver disease by facilitating inflammation and cell death. This equally holds true for cellular channels composed of pannexins, being connexin-like proteins recently identified in the liver that gather in structures reminiscent of hemichannels. This paper gives an overview of the involvement of connexin-based and pannexin-based channels in noncancerous liver disease.
Keywords
JUNCTIONAL INTERCELLULAR COMMUNICATION, ACUTE-PHASE RESPONSE, GAP-JUNCTION, CARBON-TETRACHLORIDE, KUPFFER CELLS, RAT-LIVER, EXPRESSION, CHANNELS, PROTEIN, INJURY

Citation

Please use this url to cite or link to this publication:

MLA
Cooreman, Axelle et al. “Connexin and Pannexin (hemi)channels : Emerging Targets in the Treatment of Liver Disease.” HEPATOLOGY 69.3 (2019): 1317–1323. Print.
APA
Cooreman, A., van Campenhout, R., Ballet, S., Annaert, P., Van Den Bossche, B., Colle, I., Cogliati, B., et al. (2019). Connexin and pannexin (hemi)channels : emerging targets in the treatment of liver disease. HEPATOLOGY, 69(3), 1317–1323.
Chicago author-date
Cooreman, Axelle, Raf van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, and Mathieu Vinken. 2019. “Connexin and Pannexin (hemi)channels : Emerging Targets in the Treatment of Liver Disease.” Hepatology 69 (3): 1317–1323.
Chicago author-date (all authors)
Cooreman, Axelle, Raf van Campenhout, Steven Ballet, Pieter Annaert, Bert Van Den Bossche, Isabelle Colle, Bruno Cogliati, and Mathieu Vinken. 2019. “Connexin and Pannexin (hemi)channels : Emerging Targets in the Treatment of Liver Disease.” Hepatology 69 (3): 1317–1323.
Vancouver
1.
Cooreman A, van Campenhout R, Ballet S, Annaert P, Van Den Bossche B, Colle I, et al. Connexin and pannexin (hemi)channels : emerging targets in the treatment of liver disease. HEPATOLOGY. 2019;69(3):1317–23.
IEEE
[1]
A. Cooreman et al., “Connexin and pannexin (hemi)channels : emerging targets in the treatment of liver disease,” HEPATOLOGY, vol. 69, no. 3, pp. 1317–1323, 2019.
@article{8592353,
  abstract     = {Connexin proteins are the building blocks of hemichannels, which dock further between adjacent cells to form gap junctions. Gap junctions control the intercellular exchange of critical homeostasis regulators. By doing so, gap junctions control virtually all aspects of the hepatic life cycle. In the last decade, it has become clear that connexin hemichannels also provide a pathway for cellular communication on their own independent of their role as structural precursors of gap junctions, namely between the cytosol of an individual cell and its extracellular environment. In contrast to gap junctions, connexin hemichannels become particularly active in liver disease by facilitating inflammation and cell death. This equally holds true for cellular channels composed of pannexins, being connexin-like proteins recently identified in the liver that gather in structures reminiscent of hemichannels. This paper gives an overview of the involvement of connexin-based and pannexin-based channels in noncancerous liver disease.},
  author       = {Cooreman, Axelle and van Campenhout, Raf and Ballet, Steven and Annaert, Pieter and Van Den Bossche, Bert and Colle, Isabelle and Cogliati, Bruno and Vinken, Mathieu},
  issn         = {0270-9139},
  journal      = {HEPATOLOGY},
  keywords     = {JUNCTIONAL INTERCELLULAR COMMUNICATION,ACUTE-PHASE RESPONSE,GAP-JUNCTION,CARBON-TETRACHLORIDE,KUPFFER CELLS,RAT-LIVER,EXPRESSION,CHANNELS,PROTEIN,INJURY},
  language     = {eng},
  number       = {3},
  pages        = {1317--1323},
  title        = {Connexin and pannexin (hemi)channels : emerging targets in the treatment of liver disease},
  url          = {http://dx.doi.org/10.1002/hep.30306},
  volume       = {69},
  year         = {2019},
}

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