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Keeping your armour intact : how HIV-1 evades detection by the innate immune system : HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS

(2014) BIOESSAYS. 36(7). p.649-657
Author
Organization
Abstract
HIV-1 infects dendritic cells (DCs) without triggering an effective innate antiviral immune response. As a consequence, the induction of adaptive immune responses controlling virus spread is limited. In a recent issue of Immunity, Lahaye and colleagues show that intricate interactions of HIV capsid with the cellular cofactor cyclophilin A (CypA) control infection and innate immune activation in DCs. Manipulation of HIV-1 capsid to increase its affinity for CypA results in reduced virus infectivity and facilitates access of the cytosolic DNA sensor cGAS to reverse transcribed DNA. This in turn induces a strong host response. Here, we discuss these findings in the context of recent developments in innate immunity and consider the implications for disease control and vaccine design.
Keywords
cGAS, CypA, cytosolic DNA sensor, dendritic cells, HIV-1, HIV-1 capsid, innate antiviral immunity, IMMUNODEFICIENCY-VIRUS TYPE-1, CYCLIC GMP-AMP, RESTRICTION FACTOR SAMHD1, DOUBLE-STRANDED DNA, HUMAN CYCLOPHILIN-A, DENDRITIC CELLS, I INTERFERON, INTRACELLULAR DNA, EARLY STEPS, NONDIVIDING CELLS

Citation

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Chicago
Maelfait, Jonathan, Elena Seiradake, and Jan Rehwinkel. 2014. “Keeping Your Armour Intact : How HIV-1 Evades Detection by the Innate Immune System : HIV-1 Capsid Controls Detection of Reverse Transcription Products by the Cytosolic DNA Sensor cGAS.” Bioessays 36 (7): 649–657.
APA
Maelfait, J., Seiradake, E., & Rehwinkel, J. (2014). Keeping your armour intact : how HIV-1 evades detection by the innate immune system : HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS. BIOESSAYS, 36(7), 649–657.
Vancouver
1.
Maelfait J, Seiradake E, Rehwinkel J. Keeping your armour intact : how HIV-1 evades detection by the innate immune system : HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS. BIOESSAYS. 2014;36(7):649–57.
MLA
Maelfait, Jonathan, Elena Seiradake, and Jan Rehwinkel. “Keeping Your Armour Intact : How HIV-1 Evades Detection by the Innate Immune System : HIV-1 Capsid Controls Detection of Reverse Transcription Products by the Cytosolic DNA Sensor cGAS.” BIOESSAYS 36.7 (2014): 649–657. Print.
@article{8591844,
  abstract     = {HIV-1 infects dendritic cells (DCs) without triggering an effective innate antiviral immune response. As a consequence, the induction of adaptive immune responses controlling virus spread is limited. In a recent issue of Immunity, Lahaye and colleagues show that intricate interactions of HIV capsid with the cellular cofactor cyclophilin A (CypA) control infection and innate immune activation in DCs. Manipulation of HIV-1 capsid to increase its affinity for CypA results in reduced virus infectivity and facilitates access of the cytosolic DNA sensor cGAS to reverse transcribed DNA. This in turn induces a strong host response. Here, we discuss these findings in the context of recent developments in innate immunity and consider the implications for disease control and vaccine design.},
  author       = {Maelfait, Jonathan and Seiradake, Elena and Rehwinkel, Jan},
  issn         = {0265-9247},
  journal      = {BIOESSAYS},
  language     = {eng},
  number       = {7},
  pages        = {649--657},
  title        = {Keeping your armour intact : how HIV-1 evades detection by the innate immune system : HIV-1 capsid controls detection of reverse transcription products by the cytosolic DNA sensor cGAS},
  url          = {http://dx.doi.org/10.1002/bies.201400019},
  volume       = {36},
  year         = {2014},
}

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