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Abnormal approach-related motivation but spared reinforcement learning in MDD : evidence from fronto-midline Theta oscillations and frontal Alpha asymmetry

Davide Gheza (UGent) , Jasmina Bakic (UGent) , Chris Baeken (UGent) , Rudi De Raedt (UGent) and Gilles Pourtois (UGent)
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Abstract
Major depression is characterized by abnormal reward processing and reinforcement learning (RL). This impairment might stem from deficient motivation processes, in addition to reduced reward sensitivity. In this study, we recorded 64-channel EEG in a large cohort of major depressive disorder (MDD) patients and matched healthy controls (HC) while they performed a standard RL task. Participants were asked to discover, by trial and error, several hidden stimulus-response associations having different reward probabilities, as enforced using evaluative feedback. We extracted induced fronto-midline Theta (FMT) power time-locked to the response and feedback as neurophysiological index of RL. Furthermore, we assessed approach-related motivation by measuring frontal alpha asymmetry concurrently. At the behavioral level, MDD patients and HCs showed comparable RL. At the EEG level, FMT power systematically varied as a function of reward probability, with opposing effects found at the response and feedback levels. Although this global pattern was spared in MDD, at the feedback level these patients showed however a steep FMT power decrease across trials when reward probability was low. Moreover, they showed impaired approach-related motivation during task execution, as reflected by frontal Alpha asymmetry. These results suggest a dissociation between (globally spared) RL and (impaired) approach motivation in MDD.
Keywords
Anhedonia, Reinforcement learning, Fronto-midline Theta, Medial frontal cortex, Reward prediction error, MAJOR DEPRESSIVE DISORDER, EEG ASYMMETRY, CEREBRAL ASYMMETRY, PREDICTION ERRORS, DECISION-MAKING, NEURAL RESPONSE, REWARD, FEEDBACK, DYNAMICS, DOPAMINE

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Citation

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MLA
Gheza, Davide, et al. “Abnormal Approach-Related Motivation but Spared Reinforcement Learning in MDD : Evidence from Fronto-Midline Theta Oscillations and Frontal Alpha Asymmetry.” COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, vol. 19, no. 3, 2019, pp. 759–77, doi:10.3758/s13415-019-00693-4.
APA
Gheza, D., Bakic, J., Baeken, C., De Raedt, R., & Pourtois, G. (2019). Abnormal approach-related motivation but spared reinforcement learning in MDD : evidence from fronto-midline Theta oscillations and frontal Alpha asymmetry. COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, 19(3), 759–777. https://doi.org/10.3758/s13415-019-00693-4
Chicago author-date
Gheza, Davide, Jasmina Bakic, Chris Baeken, Rudi De Raedt, and Gilles Pourtois. 2019. “Abnormal Approach-Related Motivation but Spared Reinforcement Learning in MDD : Evidence from Fronto-Midline Theta Oscillations and Frontal Alpha Asymmetry.” COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE 19 (3): 759–77. https://doi.org/10.3758/s13415-019-00693-4.
Chicago author-date (all authors)
Gheza, Davide, Jasmina Bakic, Chris Baeken, Rudi De Raedt, and Gilles Pourtois. 2019. “Abnormal Approach-Related Motivation but Spared Reinforcement Learning in MDD : Evidence from Fronto-Midline Theta Oscillations and Frontal Alpha Asymmetry.” COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE 19 (3): 759–777. doi:10.3758/s13415-019-00693-4.
Vancouver
1.
Gheza D, Bakic J, Baeken C, De Raedt R, Pourtois G. Abnormal approach-related motivation but spared reinforcement learning in MDD : evidence from fronto-midline Theta oscillations and frontal Alpha asymmetry. COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE. 2019;19(3):759–77.
IEEE
[1]
D. Gheza, J. Bakic, C. Baeken, R. De Raedt, and G. Pourtois, “Abnormal approach-related motivation but spared reinforcement learning in MDD : evidence from fronto-midline Theta oscillations and frontal Alpha asymmetry,” COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE, vol. 19, no. 3, pp. 759–777, 2019.
@article{8591434,
  abstract     = {Major depression is characterized by abnormal reward processing and reinforcement learning (RL). This impairment might stem from deficient motivation processes, in addition to reduced reward sensitivity. In this study, we recorded 64-channel EEG in a large cohort of major depressive disorder (MDD) patients and matched healthy controls (HC) while they performed a standard RL task. Participants were asked to discover, by trial and error, several hidden stimulus-response associations having different reward probabilities, as enforced using evaluative feedback. We extracted induced fronto-midline Theta (FMT) power time-locked to the response and feedback as neurophysiological index of RL. Furthermore, we assessed approach-related motivation by measuring frontal alpha asymmetry concurrently. At the behavioral level, MDD patients and HCs showed comparable RL. At the EEG level, FMT power systematically varied as a function of reward probability, with opposing effects found at the response and feedback levels. Although this global pattern was spared in MDD, at the feedback level these patients showed however a steep FMT power decrease across trials when reward probability was low. Moreover, they showed impaired approach-related motivation during task execution, as reflected by frontal Alpha asymmetry. These results suggest a dissociation between (globally spared) RL and (impaired) approach motivation in MDD.},
  author       = {Gheza, Davide and Bakic, Jasmina and Baeken, Chris and De Raedt, Rudi and Pourtois, Gilles},
  issn         = {1530-7026},
  journal      = {COGNITIVE AFFECTIVE & BEHAVIORAL NEUROSCIENCE},
  keywords     = {Anhedonia,Reinforcement learning,Fronto-midline Theta,Medial frontal cortex,Reward prediction error,MAJOR DEPRESSIVE DISORDER,EEG ASYMMETRY,CEREBRAL ASYMMETRY,PREDICTION ERRORS,DECISION-MAKING,NEURAL RESPONSE,REWARD,FEEDBACK,DYNAMICS,DOPAMINE},
  language     = {eng},
  number       = {3},
  pages        = {759--777},
  title        = {Abnormal approach-related motivation but spared reinforcement learning in MDD : evidence from fronto-midline Theta oscillations and frontal Alpha asymmetry},
  url          = {http://dx.doi.org/10.3758/s13415-019-00693-4},
  volume       = {19},
  year         = {2019},
}

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