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Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study

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Abstract
The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
Keywords
Continuous flow, Microreactors, Synthetic methods, Phenothiazine, Heterocycles, ORGANIC-SYNTHESIS, DRUG-DISCOVERY, CHEMISTRY, TOOLS

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MLA
Movsisyan, Marine, et al. “Continuous-Flow Synthesis of Phenothiazine Antipsychotics : A Feasibility Study.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 6, 2019, pp. 1350–54.
APA
Movsisyan, M., De Coen, L., Heugebaert, T., Verlee, A., Roman, B., & Stevens, C. (2019). Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, (6), 1350–1354.
Chicago author-date
Movsisyan, Marine, Laurens De Coen, Thomas Heugebaert, Arno Verlee, Bart Roman, and Christian Stevens. 2019. “Continuous-Flow Synthesis of Phenothiazine Antipsychotics : A Feasibility Study.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 6: 1350–54.
Chicago author-date (all authors)
Movsisyan, Marine, Laurens De Coen, Thomas Heugebaert, Arno Verlee, Bart Roman, and Christian Stevens. 2019. “Continuous-Flow Synthesis of Phenothiazine Antipsychotics : A Feasibility Study.” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (6): 1350–1354.
Vancouver
1.
Movsisyan M, De Coen L, Heugebaert T, Verlee A, Roman B, Stevens C. Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study. EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. 2019;(6):1350–4.
IEEE
[1]
M. Movsisyan, L. De Coen, T. Heugebaert, A. Verlee, B. Roman, and C. Stevens, “Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study,” EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, no. 6, pp. 1350–1354, 2019.
@article{8591130,
  abstract     = {{The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.}},
  author       = {{Movsisyan, Marine and De Coen, Laurens and Heugebaert, Thomas and Verlee, Arno and Roman, Bart and Stevens, Christian}},
  issn         = {{1434-193X}},
  journal      = {{EUROPEAN JOURNAL OF ORGANIC CHEMISTRY}},
  keywords     = {{Continuous flow,Microreactors,Synthetic methods,Phenothiazine,Heterocycles,ORGANIC-SYNTHESIS,DRUG-DISCOVERY,CHEMISTRY,TOOLS}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1350--1354}},
  title        = {{Continuous-flow synthesis of phenothiazine antipsychotics : a feasibility study}},
  url          = {{http://dx.doi.org/10.1002/ejoc.201801689}},
  year         = {{2019}},
}

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