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Autologous fat grafting : latest insights

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Abstract
A recent rise in the use of autologous fat transfer for soft tissue augmentation has paralleled the increasing popularity of liposuction body contouring. This creates a readily available and inexpensive product for lipografting, which is the application of lipoaspirated material. Consistent scientific proof about the long-term viability of the transferred fat is not available. Clinically, there is a reabsorption rate which has been reported to range from 20 to 90%. Results can be unpredictable with overcorrection and regular need for additional interventions. In this review, adipogenesis physiology and the adipogenic cascade from adipose-derived stem cells to adult adipocytes is extensively described to determine various procedures involved in the fat grafting technique. Variables in structure and physiology, adipose tissue harvesting- and processing techniques, and the preservation of fat grafts are taken into account to collect reproducible scientific data to establish standard in vitro and in vivo models for experimental fat grafting. Adequate histological staining for fat tissue, immunohistochemistry and viability assays should be universally used in experiments to be able to produce comparative results. By analysis of the applied methods and comparison to similar experiments, a conclusion concerning the ideal technique to improve clinical outcome is proposed.
Keywords
Fat grafting, ASC, Lipofilling, Lipotransfer, White adipose tissue engineering, CAL, Cell, MESENCHYMAL STEM-CELLS, HUMAN ADIPOSE-TISSUE, STROMAL-VASCULAR FRACTION, IN-VITRO, INTERNATIONAL-SOCIETY, CELLULAR-COMPONENTS, REGENERATIVE CELLS, ENDOTHELIAL-CELLS, DIFFERENTIATION, VIABILITY

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Citation

Please use this url to cite or link to this publication:

MLA
Doornaert, Maarten et al. “Autologous Fat Grafting : Latest Insights.” ANNALS OF MEDICINE AND SURGERY 37 (2019): 47–53. Print.
APA
Doornaert, M., Colle, J., De Maere, E., Declercq, H., & Blondeel, P. (2019). Autologous fat grafting : latest insights. ANNALS OF MEDICINE AND SURGERY, 37, 47–53.
Chicago author-date
Doornaert, Maarten, Julien Colle, Elisabeth De Maere, Heidi Declercq, and Phillip Blondeel. 2019. “Autologous Fat Grafting : Latest Insights.” Annals of Medicine and Surgery 37: 47–53.
Chicago author-date (all authors)
Doornaert, Maarten, Julien Colle, Elisabeth De Maere, Heidi Declercq, and Phillip Blondeel. 2019. “Autologous Fat Grafting : Latest Insights.” Annals of Medicine and Surgery 37: 47–53.
Vancouver
1.
Doornaert M, Colle J, De Maere E, Declercq H, Blondeel P. Autologous fat grafting : latest insights. ANNALS OF MEDICINE AND SURGERY. 2019;37:47–53.
IEEE
[1]
M. Doornaert, J. Colle, E. De Maere, H. Declercq, and P. Blondeel, “Autologous fat grafting : latest insights,” ANNALS OF MEDICINE AND SURGERY, vol. 37, pp. 47–53, 2019.
@article{8589585,
  abstract     = {A recent rise in the use of autologous fat transfer for soft tissue augmentation has paralleled the increasing popularity of liposuction body contouring. This creates a readily available and inexpensive product for lipografting, which is the application of lipoaspirated material. Consistent scientific proof about the long-term viability of the transferred fat is not available. Clinically, there is a reabsorption rate which has been reported to range from 20 to 90%. Results can be unpredictable with overcorrection and regular need for additional interventions. In this review, adipogenesis physiology and the adipogenic cascade from adipose-derived stem cells to adult adipocytes is extensively described to determine various procedures involved in the fat grafting technique. Variables in structure and physiology, adipose tissue harvesting- and processing techniques, and the preservation of fat grafts are taken into account to collect reproducible scientific data to establish standard in vitro and in vivo models for experimental fat grafting. Adequate histological staining for fat tissue, immunohistochemistry and viability assays should be universally used in experiments to be able to produce comparative results. By analysis of the applied methods and comparison to similar experiments, a conclusion concerning the ideal technique to improve clinical outcome is proposed.},
  author       = {Doornaert, Maarten and Colle, Julien and De Maere, Elisabeth and Declercq, Heidi and Blondeel, Phillip},
  issn         = {2049-0801},
  journal      = {ANNALS OF MEDICINE AND SURGERY},
  keywords     = {Fat grafting,ASC,Lipofilling,Lipotransfer,White adipose tissue engineering,CAL,Cell,MESENCHYMAL STEM-CELLS,HUMAN ADIPOSE-TISSUE,STROMAL-VASCULAR FRACTION,IN-VITRO,INTERNATIONAL-SOCIETY,CELLULAR-COMPONENTS,REGENERATIVE CELLS,ENDOTHELIAL-CELLS,DIFFERENTIATION,VIABILITY},
  language     = {eng},
  pages        = {47--53},
  title        = {Autologous fat grafting : latest insights},
  url          = {http://dx.doi.org/10.1016/j.amsu.2018.10.016},
  volume       = {37},
  year         = {2019},
}

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