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The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases

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Abstract
Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases.
Keywords
zebrafish, DDR, aging, telomeres, cancer, genome maintenance, disease model, p53, DOUBLE-STRAND BREAKS, CELLULAR SENESCENCE, GENE DISRUPTION, FANCONI-ANEMIA, DANIO-RERIO, GENOME, REPAIR, EXPRESSION, KNOCKDOWN, CELLS

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MLA
Cayuela, Maria Luisa et al. “The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases.” FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY 6 (2019): n. pag. Print.
APA
Cayuela, M. L., Claes, K., Ferreira, M. G., Henriques, C. M., van Eeden, F., Varga, M., Vierstraete, J., et al. (2019). The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 6.
Chicago author-date
Cayuela, Maria Luisa, Kathleen Claes, Miguel Godinho Ferreira, Catarina Martins Henriques, Fredericus van Eeden, Máté Varga, Jeroen Vierstraete, and Maria Caterina Mione. 2019. “The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases.” Frontiers in Cell and Developmental Biology 6.
Chicago author-date (all authors)
Cayuela, Maria Luisa, Kathleen Claes, Miguel Godinho Ferreira, Catarina Martins Henriques, Fredericus van Eeden, Máté Varga, Jeroen Vierstraete, and Maria Caterina Mione. 2019. “The Zebrafish as an Emerging Model to Study DNA Damage in Aging, Cancer and Other Diseases.” Frontiers in Cell and Developmental Biology 6.
Vancouver
1.
Cayuela ML, Claes K, Ferreira MG, Henriques CM, van Eeden F, Varga M, et al. The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases. FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2019;6.
IEEE
[1]
M. L. Cayuela et al., “The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases,” FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, vol. 6, 2019.
@article{8589549,
  abstract     = {Cancer is a disease of the elderly, and old age is its largest risk factor. With age, DNA damage accumulates continuously, increasing the chance of malignant transformation. The zebrafish has emerged as an important vertebrate model to study these processes. Key mechanisms such as DNA damage responses and cellular senescence can be studied in zebrafish throughout its life course. In addition, the zebrafish is becoming an important resource to study telomere biology in aging, regeneration and cancer. Here we review some of the tools and resources that zebrafish researchers have developed and discuss their potential use in the study of DNA damage, cancer and aging related diseases.},
  articleno    = {178},
  author       = {Cayuela, Maria Luisa and Claes, Kathleen and Ferreira, Miguel Godinho and Henriques, Catarina Martins and van Eeden, Fredericus and Varga, Máté and Vierstraete, Jeroen and Mione, Maria Caterina},
  issn         = {2296-634X},
  journal      = {FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY},
  keywords     = {zebrafish,DDR,aging,telomeres,cancer,genome maintenance,disease model,p53,DOUBLE-STRAND BREAKS,CELLULAR SENESCENCE,GENE DISRUPTION,FANCONI-ANEMIA,DANIO-RERIO,GENOME,REPAIR,EXPRESSION,KNOCKDOWN,CELLS},
  language     = {eng},
  pages        = {9},
  title        = {The zebrafish as an emerging model to study DNA damage in aging, cancer and other diseases},
  url          = {http://dx.doi.org/10.3389/fcell.2018.00178},
  volume       = {6},
  year         = {2019},
}

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