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Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity

Haixiu Wang (UGent) , Zifu Zhong (UGent) , Yu Luo, Eric Cox (UGent) and Bert Devriendt (UGent)
(2019) Toxins. 11(1).
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Abstract
Enterotoxigenic Escherichia coli (ETEC) are an important diarrhea-causing pathogen and are regarded as a global threat for humans and farm animals. ETEC possess several virulence factors to infect its host, including colonization factors and enterotoxins. Production of heat-stable enterotoxins (STs) by most ETEC plays an essential role in triggering diarrhea and ETEC pathogenesis. In this review, we summarize the heat-stable enterotoxins of ETEC strains from different species as well as the molecular mechanisms used by these heat-stable enterotoxins to trigger diarrhea. As recently described, intestinal epithelial cells are important modulators of the intestinal immune system. Thus, we also discuss the impact of the heat-stable enterotoxins on this role of the intestinal epithelium and how these enterotoxins might affect intestinal immune cells. Finally, the latest developments in vaccination strategies to protect against infections with ST secreting ETEC strains are discussed. This review might inform and guide future research on heat-stable enterotoxins to further unravel their molecular pathogenesis, as well as to accelerate vaccine design.
Keywords
E. coli, heat-stable, enterotoxins, immunity

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Citation

Please use this url to cite or link to this publication:

Chicago
Wang, Haixiu, Zifu Zhong, Yu Luo, Eric Cox, and Bert Devriendt. 2019. “Heat-Stable Enterotoxins of Enterotoxigenic Escherichia Coli and Their Impact on Host Immunity.” Toxins 11 (1).
APA
Wang, Haixiu, Zhong, Z., Luo, Y., Cox, E., & Devriendt, B. (2019). Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity. Toxins, 11(1).
Vancouver
1.
Wang H, Zhong Z, Luo Y, Cox E, Devriendt B. Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity. Toxins. MDPI AG; 2019;11(1).
MLA
Wang, Haixiu, Zifu Zhong, Yu Luo, et al. “Heat-Stable Enterotoxins of Enterotoxigenic Escherichia Coli and Their Impact on Host Immunity.” Toxins 11.1 (2019): n. pag. Print.
@article{8588551,
  abstract     = {Enterotoxigenic Escherichia coli (ETEC) are an important diarrhea-causing pathogen and are
regarded as a global threat for humans and farm animals. ETEC possess several virulence factors to
infect its host, including colonization factors and enterotoxins. Production of heat-stable enterotoxins
(STs) by most ETEC plays an essential role in triggering diarrhea and ETEC pathogenesis. In this
review, we summarize the heat-stable enterotoxins of ETEC strains from different species as well as
the molecular mechanisms used by these heat-stable enterotoxins to trigger diarrhea. As recently
described, intestinal epithelial cells are important modulators of the intestinal immune system. Thus,
we also discuss the impact of the heat-stable enterotoxins on this role of the intestinal epithelium
and how these enterotoxins might affect intestinal immune cells. Finally, the latest developments in
vaccination strategies to protect against infections with ST secreting ETEC strains are discussed. This
review might inform and guide future research on heat-stable enterotoxins to further unravel their
molecular pathogenesis, as well as to accelerate vaccine design.},
  articleno    = {24},
  author       = {Wang, Haixiu and Zhong, Zifu and Luo, Yu and Cox, Eric and Devriendt, Bert},
  issn         = {2072-6651},
  journal      = {Toxins},
  language     = {eng},
  number       = {1},
  publisher    = {MDPI AG},
  title        = {Heat-Stable Enterotoxins of Enterotoxigenic Escherichia coli and Their Impact on Host Immunity},
  url          = {http://dx.doi.org/10.3390/toxins11010024},
  volume       = {11},
  year         = {2019},
}

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