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The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution

Alexis De Tiège (UGent) , Stefaan Blancke (UGent) and Johan Braeckman (UGent)
(2018) LIFE SCIENCE PRESS. 2(1). p.70-78
Author
Organization
Abstract
Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes, the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal' interactions among genes sitting in the different individual organisms that constitute a population. It 'black-boxes' the complex 'intra-organismic' molecular and developmental epigenetics mediating between genotypes and phenotypes. To conceptually integrate epigenetics and evo-devo into evolutionary theory, advocates of an Extended Evolutionary Synthesis (EES) argue that the MS's reductive gene-centrism should be abandoned in favor of a more inclusive organism-centered approach. To push the debate to a new level of understanding, we introduce the evolutionary biology of 'intra-genomic conflict' (IGC) to the controversy. This strategy is based on a twofold rationale. First, the field of IGC is both ‘gene-centered’ and 'intra-organismic' and, as such, could build a bridge between the gene-centered MS and the intra-organismic fields of epigenetics and evo-devo. And second, it is increasingly revealed that IGC plays a significant causal role in epigenetic and developmental evolution and even in speciation. Hence, to deal with the ‘discrepancy’ between the ‘gene-centered’ MS and the ‘intra-organismic’ fields of epigenetics and evo-devo, we sketch a conceptual solution in terms of ‘intra-genomic conflict and compromise’ – an ‘intra-genomic gene’s eye view’ that thinks in terms of intra-genomic ‘evolutionarily stable strategies’ (ESSs) among numerous and various DNA regions and elements – to evolutionary-genetically underwrite both epigenetic and developmental evolution, as such questioning the ‘gene-de-centered’ stance put forward by EES-advocates.
Keywords
epigenetics, evo-devo, gene’s eye view, selfish gene(tic element), intra-genomic conflict and compromise, evolutionarily stable strategy (ESS)

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MLA
De Tiège, Alexis, Stefaan Blancke, and Johan Braeckman. “The Modern Versus Extended Evolutionary Synthesis : Sketch of an Intra-genomic Gene’s Eye View for the Evolutionary-genetic Underpinning of Epigenetic and Developmental Evolution.” LIFE SCIENCE PRESS 2.1 (2018): 70–78. Print.
APA
De Tiège, A., Blancke, S., & Braeckman, J. (2018). The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene’s eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution. LIFE SCIENCE PRESS, 2(1), 70–78.
Chicago author-date
De Tiège, Alexis, Stefaan Blancke, and Johan Braeckman. 2018. “The Modern Versus Extended Evolutionary Synthesis : Sketch of an Intra-genomic Gene’s Eye View for the Evolutionary-genetic Underpinning of Epigenetic and Developmental Evolution.” Life Science Press 2 (1): 70–78.
Chicago author-date (all authors)
De Tiège, Alexis, Stefaan Blancke, and Johan Braeckman. 2018. “The Modern Versus Extended Evolutionary Synthesis : Sketch of an Intra-genomic Gene’s Eye View for the Evolutionary-genetic Underpinning of Epigenetic and Developmental Evolution.” Life Science Press 2 (1): 70–78.
Vancouver
1.
De Tiège A, Blancke S, Braeckman J. The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene’s eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution. LIFE SCIENCE PRESS. publishingpress.info; 2018;2(1):70–8.
IEEE
[1]
A. De Tiège, S. Blancke, and J. Braeckman, “The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene’s eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution,” LIFE SCIENCE PRESS, vol. 2, no. 1, pp. 70–78, 2018.
@article{8588300,
  abstract     = {Studying the phenotypic evolution of organisms in terms of populations of genes and genotypes,
the Modern Synthesis (MS) conceptualizes biological evolution in terms of 'inter-organismal'
interactions among genes sitting in the different individual organisms that constitute a population.
It 'black-boxes' the complex 'intra-organismic' molecular and developmental epigenetics mediating
between genotypes and phenotypes. To conceptually integrate epigenetics and evo-devo into
evolutionary theory, advocates of an Extended Evolutionary Synthesis (EES) argue that the MS's
reductive gene-centrism should be abandoned in favor of a more inclusive organism-centered approach.
To push the debate to a new level of understanding, we introduce the evolutionary biology
of 'intra-genomic conflict' (IGC) to the controversy. This strategy is based on a twofold rationale.
First, the field of IGC is both ‘gene-centered’ and 'intra-organismic' and, as such, could build a
bridge between the gene-centered MS and the intra-organismic fields of epigenetics and evo-devo.
And second, it is increasingly revealed that IGC plays a significant causal role in epigenetic and
developmental evolution and even in speciation. Hence, to deal with the ‘discrepancy’ between
the ‘gene-centered’ MS and the ‘intra-organismic’ fields of epigenetics and evo-devo, we sketch
a conceptual solution in terms of ‘intra-genomic conflict and compromise’ – an ‘intra-genomic
gene’s eye view’ that thinks in terms of intra-genomic ‘evolutionarily stable strategies’ (ESSs)
among numerous and various DNA regions and elements – to evolutionary-genetically underwrite
both epigenetic and developmental evolution, as such questioning the ‘gene-de-centered’
stance put forward by EES-advocates.},
  author       = {De Tiège, Alexis and Blancke, Stefaan and Braeckman, Johan},
  journal      = {LIFE SCIENCE PRESS},
  keywords     = {epigenetics,evo-devo,gene’s eye view,selfish gene(tic element),intra-genomic conflict and compromise,evolutionarily stable strategy (ESS)},
  language     = {eng},
  number       = {1},
  pages        = {70--78},
  publisher    = {publishingpress.info},
  title        = {The modern versus extended evolutionary synthesis : sketch of an intra-genomic gene's eye view for the evolutionary-genetic underpinning of epigenetic and developmental evolution},
  url          = {http://dx.doi.org/10.28964/LifesciPress-2-111},
  volume       = {2},
  year         = {2018},
}

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