Advanced search

Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders

(2016) HUMAN BRAIN MAPPING. 37(11). p.4017-4033
Author
Organization
Abstract
Psychopathy is a serious psychiatric phenomenon characterized by a pathological constellation of affective (e.g., callous, unemotional), interpersonal (e.g., manipulative, egocentric), and behavioral (e.g., impulsive, irresponsible) personality traits. Though amygdala subregional defects are suggested in psychopathy, the functionality and connectivity of different amygdala subnuclei is typically disregarded in neurocircuit-level analyses of psychopathic personality. Hence, little is known of how amygdala subregional networks may contribute to psychopathy and its underlying trait assemblies in severely antisocial people. We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral (BLA) and centromedial (CMA) amygdala networks in relation to affective, interpersonal, and behavioral traits of psychopathy, in conduct-disordered juveniles with a history of serious delinquency (N=50, mean age=16.83 +/- 1.32). As predicted, amygdalar connectivity profiles exhibited dissociable relations with different traits of psychopathy. Interpersonal psychopathic traits not only related to increased connectivity of BLA and CMA with a corticostriatal network formation accommodating reward processing, but also predicted stronger CMA connectivity with a network of cortical midline structures supporting sociocognitive processes. In contrast, affective psychopathic traits related to diminished CMA connectivity with a frontolimbic network serving salience processing and affective responding. Finally, behavioral psychopathic traits related to heightened BLA connectivity with a frontoparietal cluster implicated in regulatory executive functioning. We suggest that these trait-specific shifts in amygdalar connectivity could be particularly relevant to the psychopathic phenotype, as they may fuel a self-centered, emotionally cold, and behaviorally disinhibited profile.
Keywords
STATE FUNCTIONAL CONNECTIVITY, DISRUPTIVE BEHAVIOR DISORDERS, CALLOUS-UNEMOTIONAL TRAITS, BRAINS DEFAULT NETWORK, VERSION PCL-YV, POSTTRAUMATIC-STRESS, ANTISOCIAL-BEHAVIOR, PREFRONTAL CORTEX, EARLY, ADOLESCENCE, YOUTH VERSION, amygdala, psychopathy, conduct disorder, intrinsic functional, connectivity

Citation

Please use this url to cite or link to this publication:

Chicago
Aghajani, Moji, Olivier Colins, Eduard T Klapwijk, Ilya M Veer, Henrik Andershed, Arne Popma, Nic J van der Wee, and Robert RJM Vermeiren. 2016. “Dissociable Relations Between Amygdala Subregional Networks and Psychopathy Trait Dimensions in Conduct-disordered Juvenile Offenders.” Human Brain Mapping 37 (11): 4017–4033.
APA
Aghajani, M., Colins, O., Klapwijk, E. T., Veer, I. M., Andershed, H., Popma, A., van der Wee, N. J., et al. (2016). Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders. HUMAN BRAIN MAPPING, 37(11), 4017–4033.
Vancouver
1.
Aghajani M, Colins O, Klapwijk ET, Veer IM, Andershed H, Popma A, et al. Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders. HUMAN BRAIN MAPPING. 2016;37(11):4017–33.
MLA
Aghajani, Moji et al. “Dissociable Relations Between Amygdala Subregional Networks and Psychopathy Trait Dimensions in Conduct-disordered Juvenile Offenders.” HUMAN BRAIN MAPPING 37.11 (2016): 4017–4033. Print.
@article{8588088,
  abstract     = {Psychopathy is a serious psychiatric phenomenon characterized by a pathological constellation of affective (e.g., callous, unemotional), interpersonal (e.g., manipulative, egocentric), and behavioral (e.g., impulsive, irresponsible) personality traits. Though amygdala subregional defects are suggested in psychopathy, the functionality and connectivity of different amygdala subnuclei is typically disregarded in neurocircuit-level analyses of psychopathic personality. Hence, little is known of how amygdala subregional networks may contribute to psychopathy and its underlying trait assemblies in severely antisocial people. We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral (BLA) and centromedial (CMA) amygdala networks in relation to affective, interpersonal, and behavioral traits of psychopathy, in conduct-disordered juveniles with a history of serious delinquency (N=50, mean age=16.83 +/- 1.32). As predicted, amygdalar connectivity profiles exhibited dissociable relations with different traits of psychopathy. Interpersonal psychopathic traits not only related to increased connectivity of BLA and CMA with a corticostriatal network formation accommodating reward processing, but also predicted stronger CMA connectivity with a network of cortical midline structures supporting sociocognitive processes. In contrast, affective psychopathic traits related to diminished CMA connectivity with a frontolimbic network serving salience processing and affective responding. Finally, behavioral psychopathic traits related to heightened BLA connectivity with a frontoparietal cluster implicated in regulatory executive functioning. We suggest that these trait-specific shifts in amygdalar connectivity could be particularly relevant to the psychopathic phenotype, as they may fuel a self-centered, emotionally cold, and behaviorally disinhibited profile.},
  author       = {Aghajani, Moji and Colins, Olivier and Klapwijk, Eduard T and Veer, Ilya M and Andershed, Henrik and Popma, Arne and van der Wee, Nic J and Vermeiren, Robert RJM},
  issn         = {1065-9471},
  journal      = {HUMAN BRAIN MAPPING},
  language     = {eng},
  number       = {11},
  pages        = {4017--4033},
  title        = {Dissociable relations between amygdala subregional networks and psychopathy trait dimensions in conduct-disordered juvenile offenders},
  url          = {http://dx.doi.org/10.1002/hbm.23292},
  volume       = {37},
  year         = {2016},
}

Altmetric
View in Altmetric
Web of Science
Times cited: