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Disorganized Amygdala networks in conduct-disordered juvenile offenders with callous-unemotional traits

(2017) BIOLOGICAL PSYCHIATRY. 82(4). p.283-293
Author
Organization
Abstract
BACKGROUND: The developmental trajectory of psychopathy seemingly begins early in life and includes the presence of callous-unemotional (CU) traits (e.g., deficient emotional reactivity, callousness) in conduct-disordered (CD) youth. Though subregion-specific anomalies in amygdala function have been suggested in CU pathophysiology among antisocial populations, system-level studies of CU traits have typically examined the amygdala as a unitary structure. Hence, nothing is yet known of how amygdala subregional network function may contribute to callous-unemotionality in severely antisocial people. METHODS: We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral amygdala (BLA) and centromedial amygdala (CMA) networks across three matched groups of juveniles: CD offenders with CU traits (CD/CU+; n = 25), CD offenders without CU traits (CD/CU-; n = 25), and healthy control subjects (n = 24). We additionally examined whether perturbed amygdala subregional connectivity coincides with altered volume and shape of the amygdaloid complex. RESULTS: Relative to CD/CU- and healthy control youths, CD/CU+ youths showed abnormally increased BLA connectivity with a cluster that included both dorsal and ventral portions of the anterior cingulate and medial prefrontal cortices, along with posterior cingulate, sensory associative, and striatal regions. In contrast, compared with CD/CU- and healthy control youths, CD/CU+ youths showed diminished CMA connectivity with ventromedial/orbitofrontal regions. Critically, these connectivity changes coincided with local hypotrophy of BLA and CMA subregions (without being statistically correlated) and were associated to more severe CU symptoms. CONCLUSIONS: These findings provide unique insights into a putative mechanism for perturbed attention-emotion interactions, which could bias salience processing and associative learning in youth with CD/CU+.
Keywords
DISRUPTIVE BEHAVIOR DISORDERS, GENERALIZED ANXIETY DISORDER, PSYCHOPATHIC TRAITS, PREFRONTAL CORTEX, FUNCTIONAL CONNECTIVITY, BASOLATERAL AMYGDALA, INHIBITORY CIRCUITS, ANTISOCIAL-BEHAVIOR, COGNITIVE CONTROL, CONDITIONED FEAR, Amygdala, Callous-unemotional traits, Conduct disorder, Intrinsic, functional connectivity, Morphometry, Psychopathy

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Chicago
Aghajani, Moji, Eduard T. Klapwijk, Nic J. van der Wee, Ilya M. Veer, Serge A. R. B. Rombouts, Albert E. Boon, Peter van Beelen, Arne Popma, Robert R. J. M. Vermeiren, and Olivier Colins. 2017. “Disorganized Amygdala Networks in Conduct-disordered Juvenile Offenders with Callous-unemotional Traits.” Biological Psychiatry 82 (4): 283–293.
APA
Aghajani, Moji, Klapwijk, E. T., van der Wee, N. J., Veer, I. M., Rombouts, S. A. R. B., Boon, A. E., van Beelen, P., et al. (2017). Disorganized Amygdala networks in conduct-disordered juvenile offenders with callous-unemotional traits. BIOLOGICAL PSYCHIATRY, 82(4), 283–293.
Vancouver
1.
Aghajani M, Klapwijk ET, van der Wee NJ, Veer IM, Rombouts SARB, Boon AE, et al. Disorganized Amygdala networks in conduct-disordered juvenile offenders with callous-unemotional traits. BIOLOGICAL PSYCHIATRY. New york: Elsevier Science Inc; 2017;82(4):283–93.
MLA
Aghajani, Moji et al. “Disorganized Amygdala Networks in Conduct-disordered Juvenile Offenders with Callous-unemotional Traits.” BIOLOGICAL PSYCHIATRY 82.4 (2017): 283–293. Print.
@article{8588075,
  abstract     = {BACKGROUND: The developmental trajectory of psychopathy seemingly begins early in life and includes the presence of callous-unemotional (CU) traits (e.g., deficient emotional reactivity, callousness) in conduct-disordered (CD) youth. Though subregion-specific anomalies in amygdala function have been suggested in CU pathophysiology among antisocial populations, system-level studies of CU traits have typically examined the amygdala as a unitary structure. Hence, nothing is yet known of how amygdala subregional network function may contribute to callous-unemotionality in severely antisocial people. METHODS: We addressed this important issue by uniquely examining the intrinsic functional connectivity of basolateral amygdala (BLA) and centromedial amygdala (CMA) networks across three matched groups of juveniles: CD offenders with CU traits (CD/CU+; n = 25), CD offenders without CU traits (CD/CU-; n = 25), and healthy control subjects (n = 24). We additionally examined whether perturbed amygdala subregional connectivity coincides with altered volume and shape of the amygdaloid complex. RESULTS: Relative to CD/CU- and healthy control youths, CD/CU+ youths showed abnormally increased BLA connectivity with a cluster that included both dorsal and ventral portions of the anterior cingulate and medial prefrontal cortices, along with posterior cingulate, sensory associative, and striatal regions. In contrast, compared with CD/CU- and healthy control youths, CD/CU+ youths showed diminished CMA connectivity with ventromedial/orbitofrontal regions. Critically, these connectivity changes coincided with local hypotrophy of BLA and CMA subregions (without being statistically correlated) and were associated to more severe CU symptoms. CONCLUSIONS: These findings provide unique insights into a putative mechanism for perturbed attention-emotion interactions, which could bias salience processing and associative learning in youth with CD/CU+.},
  author       = {Aghajani, Moji and Klapwijk, Eduard T. and van der Wee, Nic J. and Veer, Ilya M. and Rombouts, Serge A. R. B. and Boon, Albert E. and van Beelen, Peter and Popma, Arne and Vermeiren, Robert R. J. M. and Colins, Olivier},
  issn         = {0006-3223},
  journal      = {BIOLOGICAL PSYCHIATRY},
  keywords     = {DISRUPTIVE BEHAVIOR DISORDERS,GENERALIZED ANXIETY DISORDER,PSYCHOPATHIC TRAITS,PREFRONTAL CORTEX,FUNCTIONAL CONNECTIVITY,BASOLATERAL AMYGDALA,INHIBITORY CIRCUITS,ANTISOCIAL-BEHAVIOR,COGNITIVE CONTROL,CONDITIONED FEAR,Amygdala,Callous-unemotional traits,Conduct disorder,Intrinsic,functional connectivity,Morphometry,Psychopathy},
  language     = {eng},
  number       = {4},
  pages        = {283--293},
  publisher    = {Elsevier Science Inc},
  title        = {Disorganized Amygdala networks in conduct-disordered juvenile offenders with callous-unemotional traits},
  url          = {http://dx.doi.org/10.1016/j.biopsych.2016.05.017},
  volume       = {82},
  year         = {2017},
}

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