Advanced search
1 file | 919.34 KB

Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function

(2018) BRITISH JOURNAL OF NUTRITION. 120(10). p.1159-1170
Author
Organization
Abstract
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (SD 29) nmol/l for EA and 49 (SD 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1.1 ml in EA (95 % CI 0.9, 1.3; P< 0.0001) and 1.8 ml (95 % CI 1.1, 2.5; P< 0.0001) in AA (P-race (difference) = 0.06), and forced vital capacity (FVC) was higher by 1.3 ml in EA (95 % CI 1.0, 1.6; P <0.0001) and 1.5 ml (95 % CI 0.8, 2.3; P= 0.0001) in AA (P-race difference = 0.56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH) D, FVC was higher by 1.7 ml (95 % CI 1.1, 2.3) for current smokers and 1.7 ml (95 % CI 1.2, 2.1) for former smokers, compared with 0.8 ml (95 % CI 0.4, 1.2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.
Keywords
NUTRITION EXAMINATION SURVEY, PLASMA 25-HYDROXYVITAMIN D, D-BINDING PROTEIN, LUNG-FUNCTION, NATIONAL-HEALTH, CIGARETTE-SMOKING, PHYSICAL-ACTIVITY, UNITED-STATES, ADULTS, DISEASE, Vitamin D, Forced expiratory volume, Vital capacity, Respiratory function tests, Smoking, Whites, African Americans

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 919.34 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Xu, Jiayi, Traci M Bartz, Geetha Chittoor, Gudny Eiriksdottir, Ani W Manichaikul, Fangui Sun, Natalie Terzikhan, et al. 2018. “Meta-analysis Across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Provides Evidence for an Association of Serum Vitamin D with Pulmonary Function.” British Journal of Nutrition 120 (10): 1159–1170.
APA
Xu, Jiayi, Bartz, T. M., Chittoor, G., Eiriksdottir, G., Manichaikul, A. W., Sun, F., Terzikhan, N., et al. (2018). Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. BRITISH JOURNAL OF NUTRITION, 120(10), 1159–1170.
Vancouver
1.
Xu J, Bartz TM, Chittoor G, Eiriksdottir G, Manichaikul AW, Sun F, et al. Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function. BRITISH JOURNAL OF NUTRITION. 2018;120(10):1159–70.
MLA
Xu, Jiayi et al. “Meta-analysis Across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium Provides Evidence for an Association of Serum Vitamin D with Pulmonary Function.” BRITISH JOURNAL OF NUTRITION 120.10 (2018): 1159–1170. Print.
@article{8587595,
  abstract     = {The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (SD 29) nmol/l for EA and 49 (SD 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1.1 ml in EA (95 \% CI 0.9, 1.3; P{\textlangle} 0.0001) and 1.8 ml (95 \% CI 1.1, 2.5; P{\textlangle} 0.0001) in AA (P-race (difference) = 0.06), and forced vital capacity (FVC) was higher by 1.3 ml in EA (95 \% CI 1.0, 1.6; P {\textlangle}0.0001) and 1.5 ml (95 \% CI 0.8, 2.3; P= 0.0001) in AA (P-race difference = 0.56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH) D, FVC was higher by 1.7 ml (95 \% CI 1.1, 2.3) for current smokers and 1.7 ml (95 \% CI 1.2, 2.1) for former smokers, compared with 0.8 ml (95 \% CI 0.4, 1.2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.},
  author       = {Xu, Jiayi and Bartz, Traci M and Chittoor, Geetha and Eiriksdottir, Gudny and Manichaikul, Ani W and Sun, Fangui and Terzikhan, Natalie and Zhou, Xia and Booth, Sarah L and Brusselle, Guy and de Boer, Ian H and Fornage, Myriam and Frazier-Wood, Alexis C and Graff, Mariaelisa and Gudnason, Vilmundur and Harris, Tamara B and Hofman, Albert and Hou, Ruixue and Houston, Denise K and Jacobs, David R, Jr and Kritchevsky, Stephen B and Latourelle, Jeanne and Lemaitre, Rozenn N and Lutsey, Pamela L and O'Connor, George and Oelsner, Elizabeth C and Pankow, James S and Psaty, Bruce M and Rohde, Rebecca R and Rich, Stephen S and Rotter, Jerome I and Smith, Lewis J and Stricker, Bruno H and Voruganti, V Saroja and Wang, Thomas J and Zillikens, M Carola and Barr, R Graham and Dupuis, Josee and Gharib, Sina A and Lahousse, Lies and London, Stephanie J and North, Kari E and Smith, Albert V and Steffen, Lyn M and Hancock, Dana B and Cassano, Patricia A},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  language     = {eng},
  number       = {10},
  pages        = {1159--1170},
  title        = {Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function},
  url          = {http://dx.doi.org/10.1017/S0007114518002180},
  volume       = {120},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: