Advanced search
1 file | 946.26 KB

Mycotoxin Biomarkers of Exposure: A Comprehensive Review

Author
Organization
Abstract
To date, the use of biomarkers has become generally accepted. Biomarker-driven research has been proposed as a successful method to assess the exposure to xenobiotics by using concentrations of the parent compounds and/or metabolites in biological matrices such as urine or blood. However, the identification and validation of biomarkers of exposure remain a challenge. Recent advances in high-resolution mass spectrometry along with new analytical (post-acquisition data-mining) techniques will improve the quality and output of the biomarker identification process. Chronic or even acute exposure to mycotoxins remains a daily fact, and therefore it is crucial that the mycotoxins' metabolism is unravelled so more knowledge on biomarkers in humans and animals is acquired. This review aims to provide the scientific community with a comprehensive overview of reported in vitro and in vivo mycotoxin metabolism studies in relation to biomarkers of exposure for deoxynivalenol, nivalenol, fusarenon-X, T-2 toxin, diacetoxyscirpenol, ochratoxin A, citrinin, fumonisins, zearalenone, aflatoxins, and sterigmatocystin.
Keywords
biomarkers, exposure, human, in vitro, in vivo, metabolism, mycotoxin, PERFORMANCE LIQUID-CHROMATOGRAPHY, AFLATOXIN-ALBUMIN ADDUCTS, TANDEM MASS-SPECTROMETRY, IN-VIVO METABOLISM, VITRO GASTROINTESTINAL MODEL, ORALLY-ADMINISTERED RATS, HUMAN BREAST-MILK, FUMONISIN B-1, T-2 TOXIN, OCHRATOXIN-A

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 946.26 KB

Citation

Please use this url to cite or link to this publication:

Chicago
Vidal Corominas, Arnau, Marcel Mengelers, Shupeng Yang, Sarah De Saeger, and Marthe De Boevre. 2018. “Mycotoxin Biomarkers of Exposure: A Comprehensive Review.” Comprehensive Reviews in Food Science and Food Safety 17 (5): 1127–1155.
APA
Vidal Corominas, A., Mengelers, M., Yang, S., De Saeger, S., & De Boevre, M. (2018). Mycotoxin Biomarkers of Exposure: A Comprehensive Review. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY, 17(5), 1127–1155.
Vancouver
1.
Vidal Corominas A, Mengelers M, Yang S, De Saeger S, De Boevre M. Mycotoxin Biomarkers of Exposure: A Comprehensive Review. COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY. 2018;17(5):1127–55.
MLA
Vidal Corominas, Arnau, Marcel Mengelers, Shupeng Yang, et al. “Mycotoxin Biomarkers of Exposure: A Comprehensive Review.” COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY 17.5 (2018): 1127–1155. Print.
@article{8587116,
  abstract     = {To date, the use of biomarkers has become generally accepted. Biomarker-driven research has been proposed as a successful method to assess the exposure to xenobiotics by using concentrations of the parent compounds and/or metabolites in biological matrices such as urine or blood. However, the identification and validation of biomarkers of exposure remain a challenge. Recent advances in high-resolution mass spectrometry along with new analytical (post-acquisition data-mining) techniques will improve the quality and output of the biomarker identification process. Chronic or even acute exposure to mycotoxins remains a daily fact, and therefore it is crucial that the mycotoxins' metabolism is unravelled so more knowledge on biomarkers in humans and animals is acquired. This review aims to provide the scientific community with a comprehensive overview of reported in vitro and in vivo mycotoxin metabolism studies in relation to biomarkers of exposure for deoxynivalenol, nivalenol, fusarenon-X, T-2 toxin, diacetoxyscirpenol, ochratoxin A, citrinin, fumonisins, zearalenone, aflatoxins, and sterigmatocystin.},
  author       = {Vidal Corominas, Arnau and Mengelers, Marcel and Yang, Shupeng and De Saeger, Sarah and De Boevre, Marthe},
  issn         = {1541-4337},
  journal      = {COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY},
  number       = {5},
  pages        = {1127--1155},
  title        = {Mycotoxin Biomarkers of Exposure: A Comprehensive Review},
  url          = {http://dx.doi.org/10.1111/1541-4337.12367},
  volume       = {17},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: