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Effect of crosslinking stage on photocrosslinking of benzophenone functionalized poly(2-ethyl-2-oxazoline) nanofibers obtained by aqueous electrospinning

Yin Li (UGent) , Maarten Vergaelen (UGent) , Ella Schoolaert (UGent) , Richard Hoogenboom (UGent) and Karen De Clerck (UGent)
(2019) EUROPEAN POLYMER JOURNAL. 112. p.24-30
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Abstract
In this study, benzophenone was introduced onto partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx-PEI) to prepare a poly(2-ethyl-2-oxazoline)-benzophenone (PEtOx-BP) copolymer, which was used to produce water stable nanofibers via aqueous electrospinning and photocrosslinking. Three different ultraviolet (UV) irradiation methods, i.e. pre-crosslinking before electrospinning, in-situ crosslinking during electrospinning and post-crosslinking after electrospinning, were used to prepare crosslinked nanofibers. The influence of UV-irradiation at these different stages of the nanofiber production process was investigated in terms of alterations in viscosity, nanofiber morphology and water stability of the fibers. It was shown that pre-crosslinking the polymer solutions had a great influence on the solution viscosity which could both positively or negatively alter the stability of the electrospinning process. Whereas the strategy of crosslinking nanofibers during the production process did not lead to uniform nor water-stable nanofibers, the pre-crosslinking and post-crosslinking strategies greatly increased the water stability of the nanofibers. In both techniques the crosslinking density and therefore water solubility can be easily tuned by manipulating the polymer concentration, UV-irradiation time and membrane thickness. Complete insolubility, i.e. the formation of crosslinked networks, was achieved by the post-cross linking strategy. This work provides straightforward methods to increase the water stability of the PEtOx nanofibers, which will definitely be of great value to biomedical applications such as drug delivery and tissue engineering.
Keywords
Electrospinning, Poly(2-ethyl-2-oxazoline), Benzophenone, UV-irradiation, Crosslinking, Nanofibers, POLY(ETHYLENE OXIDE), NANOPARTICLES, CHEMISTRY, FIBERS

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Citation

Please use this url to cite or link to this publication:

MLA
Li, Yin, et al. “Effect of Crosslinking Stage on Photocrosslinking of Benzophenone Functionalized Poly(2-Ethyl-2-Oxazoline) Nanofibers Obtained by Aqueous Electrospinning.” EUROPEAN POLYMER JOURNAL, vol. 112, 2019, pp. 24–30.
APA
Li, Y., Vergaelen, M., Schoolaert, E., Hoogenboom, R., & De Clerck, K. (2019). Effect of crosslinking stage on photocrosslinking of benzophenone functionalized poly(2-ethyl-2-oxazoline) nanofibers obtained by aqueous electrospinning. EUROPEAN POLYMER JOURNAL, 112, 24–30.
Chicago author-date
Li, Yin, Maarten Vergaelen, Ella Schoolaert, Richard Hoogenboom, and Karen De Clerck. 2019. “Effect of Crosslinking Stage on Photocrosslinking of Benzophenone Functionalized Poly(2-Ethyl-2-Oxazoline) Nanofibers Obtained by Aqueous Electrospinning.” EUROPEAN POLYMER JOURNAL 112: 24–30.
Chicago author-date (all authors)
Li, Yin, Maarten Vergaelen, Ella Schoolaert, Richard Hoogenboom, and Karen De Clerck. 2019. “Effect of Crosslinking Stage on Photocrosslinking of Benzophenone Functionalized Poly(2-Ethyl-2-Oxazoline) Nanofibers Obtained by Aqueous Electrospinning.” EUROPEAN POLYMER JOURNAL 112: 24–30.
Vancouver
1.
Li Y, Vergaelen M, Schoolaert E, Hoogenboom R, De Clerck K. Effect of crosslinking stage on photocrosslinking of benzophenone functionalized poly(2-ethyl-2-oxazoline) nanofibers obtained by aqueous electrospinning. EUROPEAN POLYMER JOURNAL. 2019;112:24–30.
IEEE
[1]
Y. Li, M. Vergaelen, E. Schoolaert, R. Hoogenboom, and K. De Clerck, “Effect of crosslinking stage on photocrosslinking of benzophenone functionalized poly(2-ethyl-2-oxazoline) nanofibers obtained by aqueous electrospinning,” EUROPEAN POLYMER JOURNAL, vol. 112, pp. 24–30, 2019.
@article{8586957,
  abstract     = {In this study, benzophenone was introduced onto partially hydrolyzed poly(2-ethyl-2-oxazoline) (PEtOx-PEI) to prepare a poly(2-ethyl-2-oxazoline)-benzophenone (PEtOx-BP) copolymer, which was used to produce water stable nanofibers via aqueous electrospinning and photocrosslinking. Three different ultraviolet (UV) irradiation methods, i.e. pre-crosslinking before electrospinning, in-situ crosslinking during electrospinning and post-crosslinking after electrospinning, were used to prepare crosslinked nanofibers. The influence of UV-irradiation at these different stages of the nanofiber production process was investigated in terms of alterations in viscosity, nanofiber morphology and water stability of the fibers. It was shown that pre-crosslinking the polymer solutions had a great influence on the solution viscosity which could both positively or negatively alter the stability of the electrospinning process. Whereas the strategy of crosslinking nanofibers during the production process did not lead to uniform nor water-stable nanofibers, the pre-crosslinking and post-crosslinking strategies greatly increased the water stability of the nanofibers. In both techniques the crosslinking density and therefore water solubility can be easily tuned by manipulating the polymer concentration, UV-irradiation time and membrane thickness. Complete insolubility, i.e. the formation of crosslinked networks, was achieved by the post-cross linking strategy. This work provides straightforward methods to increase the water stability of the PEtOx nanofibers, which will definitely be of great value to biomedical applications such as drug delivery and tissue engineering.},
  author       = {Li, Yin and Vergaelen, Maarten and Schoolaert, Ella and Hoogenboom, Richard and De Clerck, Karen},
  issn         = {0014-3057},
  journal      = {EUROPEAN POLYMER JOURNAL},
  keywords     = {Electrospinning,Poly(2-ethyl-2-oxazoline),Benzophenone,UV-irradiation,Crosslinking,Nanofibers,POLY(ETHYLENE OXIDE),NANOPARTICLES,CHEMISTRY,FIBERS},
  language     = {eng},
  pages        = {24--30},
  title        = {Effect of crosslinking stage on photocrosslinking of benzophenone functionalized poly(2-ethyl-2-oxazoline) nanofibers obtained by aqueous electrospinning},
  url          = {http://dx.doi.org/10.1016/j.eurpolymj.2018.12.030},
  volume       = {112},
  year         = {2019},
}

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