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Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

(2019) CARBOHYDRATE POLYMERS. 205. p.427-436
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Abstract
The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and < 45 mu m). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. mu CT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.
Keywords
Hydrogel, Pectin, Bioactive glass, Antibacterial, Bone tissue engineering, CROSS-LINKING, BONE REGENERATION, IN-VITRO, HYDROGELS, HYDROXYAPATITE, CALCIUM, BEHAVIOR, SYSTEM, MICRO, SIZE

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Citation

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MLA
Douglas, Timothy, Michal Dziadek, Josefien Schietse, et al. “Pectin-bioactive Glass Self-gelling, Injectable Composites with High Antibacterial Activity.” CARBOHYDRATE POLYMERS 205 (2019): 427–436. Print.
APA
Douglas, Timothy, Dziadek, M., Schietse, J., Boone, M., Declercq, H., Coenye, T., Vanhoorne, V., et al. (2019). Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. CARBOHYDRATE POLYMERS, 205, 427–436.
Chicago author-date
Douglas, Timothy, Michal Dziadek, Josefien Schietse, Matthieu Boone, Heidi Declercq, Tom Coenye, Valérie Vanhoorne, et al. 2019. “Pectin-bioactive Glass Self-gelling, Injectable Composites with High Antibacterial Activity.” Carbohydrate Polymers 205: 427–436.
Chicago author-date (all authors)
Douglas, Timothy, Michal Dziadek, Josefien Schietse, Matthieu Boone, Heidi Declercq, Tom Coenye, Valérie Vanhoorne, Chris Vervaet, Lieve Balcaen, Maria Buchweitz, Frank Vanhaecke, Frederic Van Assche, Katarzyna Cholewa-Kowalska, and Andre Skirtach. 2019. “Pectin-bioactive Glass Self-gelling, Injectable Composites with High Antibacterial Activity.” Carbohydrate Polymers 205: 427–436.
Vancouver
1.
Douglas T, Dziadek M, Schietse J, Boone M, Declercq H, Coenye T, et al. Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. CARBOHYDRATE POLYMERS. 2019;205:427–36.
IEEE
[1]
T. Douglas et al., “Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity,” CARBOHYDRATE POLYMERS, vol. 205, pp. 427–436, 2019.
@article{8586868,
  abstract     = {The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and < 45 mu m). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. mu CT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.},
  author       = {Douglas, Timothy and Dziadek, Michal and Schietse, Josefien and Boone, Matthieu and Declercq, Heidi and Coenye, Tom and Vanhoorne, Valérie and Vervaet, Chris and Balcaen, Lieve and Buchweitz, Maria and Vanhaecke, Frank and Van Assche, Frederic and Cholewa-Kowalska, Katarzyna and Skirtach, Andre},
  issn         = {0144-8617},
  journal      = {CARBOHYDRATE POLYMERS},
  keywords     = {Hydrogel,Pectin,Bioactive glass,Antibacterial,Bone tissue engineering,CROSS-LINKING,BONE REGENERATION,IN-VITRO,HYDROGELS,HYDROXYAPATITE,CALCIUM,BEHAVIOR,SYSTEM,MICRO,SIZE},
  language     = {eng},
  pages        = {427--436},
  title        = {Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity},
  url          = {http://dx.doi.org/10.1016/j.carbpol.2018.10.061},
  volume       = {205},
  year         = {2019},
}

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