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Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity

(2019) CARBOHYDRATE POLYMERS. 205. p.427-436
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Abstract
The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20% w/v BG particles of two different sizes (2.5 and < 45 mu m). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. mu CT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.
Keywords
Hydrogel, Pectin, Bioactive glass, Antibacterial, Bone tissue engineering, CROSS-LINKING, BONE REGENERATION, IN-VITRO, HYDROGELS, HYDROXYAPATITE, CALCIUM, BEHAVIOR, SYSTEM, MICRO, SIZE

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Chicago
Douglas, Timothy, Michal Dziadek, Josefien Schietse, Matthieu Boone, Heidi Declercq, Tom Coenye, Valérie Vanhoorne, et al. 2019. “Pectin-bioactive Glass Self-gelling, Injectable Composites with High Antibacterial Activity.” Carbohydrate Polymers 205: 427–436.
APA
Douglas, Timothy, Dziadek, M., Schietse, J., Boone, M., Declercq, H., Coenye, T., Vanhoorne, V., et al. (2019). Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. CARBOHYDRATE POLYMERS, 205, 427–436.
Vancouver
1.
Douglas T, Dziadek M, Schietse J, Boone M, Declercq H, Coenye T, et al. Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity. CARBOHYDRATE POLYMERS. 2019;205:427–36.
MLA
Douglas, Timothy, Michal Dziadek, Josefien Schietse, et al. “Pectin-bioactive Glass Self-gelling, Injectable Composites with High Antibacterial Activity.” CARBOHYDRATE POLYMERS 205 (2019): 427–436. Print.
@article{8586868,
  abstract     = {The present work focuses on the development of novel injectable, self-gelling composite hydrogels based on two types of low esterified amidated pectins from citrus peels and apple pomace. Sol-gel-derived, calcium-rich bioactive glass (BG) fillers in a particle form are applied as delivery vehicles for the release of Ca2+ ions to induce internal gelation of pectins. Composites were prepared by a relatively simple mixing technique, using 20\% w/v BG particles of two different sizes (2.5 and {\textlangle} 45 mu m). Smaller particles accelerated pectin gelation slightly faster than bigger ones, which appears to result from the higher rate of Ca2+ ion release. mu CT showed inhomogeneous distribution of the BG particles within the hydrogels. All composite hydrogels exhibited strong antibacterial activity against methicilin-resistant Staphylococcus aureus. The mineralization process of pectin-BG composite hydrogels occurred upon incubation in simulated body fluid for 28 days. In vitro studies demonstrated cytocompatibility of composite hydrogels with MC3T3-E1 osteoblastic cells.},
  author       = {Douglas, Timothy and Dziadek, Michal and Schietse, Josefien and Boone, Matthieu and Declercq, Heidi and Coenye, Tom and Vanhoorne, Val{\'e}rie and Vervaet, Chris and Balcaen, Lieve and Buchweitz, Maria and Vanhaecke, Frank and Van Assche, Frederic and Cholewa-Kowalska, Katarzyna and Skirtach, Andre},
  issn         = {0144-8617},
  journal      = {CARBOHYDRATE POLYMERS},
  language     = {eng},
  pages        = {427--436},
  title        = {Pectin-bioactive glass self-gelling, injectable composites with high antibacterial activity},
  url          = {http://dx.doi.org/10.1016/j.carbpol.2018.10.061},
  volume       = {205},
  year         = {2019},
}

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