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Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis

(2019) LANCET INFECTIOUS DISEASES. 19(1). p.56-66
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Abstract
Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs). Methods: We estimated the incidence of infections with 16 antibiotic resistance–bacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011–12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature. Findings: From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671 689 (95% uncertainty interval [UI] 583 148–763 966) infections with antibiotic-resistant bacteria, of which 63·5% (426 277 of 671 689) were associated with health care. These infections accounted for an estimated 33 110 (28 480–38 430) attributable deaths and 874 541 (768 837–989 068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece. Interpretation: Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.
Keywords
CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE

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MLA
Cassini, Alessandro et al. “Attributable Deaths and Disability-adjusted Life-years Caused by Infections with Antibiotic-resistant Bacteria in the EU and the European Economic Area in 2015 : a Population-level Modelling Analysis.” LANCET INFECTIOUS DISEASES 19.1 (2019): 56–66. Print.
APA
Cassini, A., Högberg, L. D., Plachouras, D., Quattrocchi, A., Hoxha, A., Simonsen, G. S., Colomb-Cotinat, M., et al. (2019). Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis. LANCET INFECTIOUS DISEASES, 19(1), 56–66.
Chicago author-date
Cassini, Alessandro, Liselotte Diaz Högberg, Diamantis Plachouras, Annalisa Quattrocchi, Ana Hoxha, Gunnar Skov Simonsen, Mélanie Colomb-Cotinat, et al. 2019. “Attributable Deaths and Disability-adjusted Life-years Caused by Infections with Antibiotic-resistant Bacteria in the EU and the European Economic Area in 2015 : a Population-level Modelling Analysis.” Lancet Infectious Diseases 19 (1): 56–66.
Chicago author-date (all authors)
Cassini, Alessandro, Liselotte Diaz Högberg, Diamantis Plachouras, Annalisa Quattrocchi, Ana Hoxha, Gunnar Skov Simonsen, Mélanie Colomb-Cotinat, Mirjam E Kretzschmar, Brecht Devleesschauwer, Michele Cecchini, Driss Ait Ouakrim, Tiago Cravo Oliveira, Marc J Struelens, Carl Suetens, Dominique L Monnet, Reinhild Strauss, Karl Mertens, Thomas Struyf, Boudewijn Catry, Katrien Latour, Ivan N Ivanov, Elina G Dobreva, Arjana Tambic Andraševic, Silvija Soprek, Ana Budimir, Niki Paphitou, Helena Žemlicková, Stefan Schytte Olsen, Ute Wolff Sönksen, Pille Märtin, Marina Ivanova, Outi Lyytikäinen, Jari Jalava, Bruno Coignard, Tim Eckmanns, Muna Abu Sin, Sebastian Haller, George L Daikos, Achilleas Gikas, Sotirios Tsiodras, Flora Kontopidou, Ákos Tóth, Ágnes Hajdu, Ólafur Guólaugsson, Karl G Kristinsson, Stephen Murchan, Karen Burns, Patrizio Pezzotti, Carlo Gagliotti, Uga Dumpis, Agne Liuimiene, Monique Perrin, Michael A Borg, Sabine C de Greeff, Jos CM Monen, Mayke BG Koek, Petter Elstrøm, Dorota Zabicka, Aleksander Deptula, Waleria Hryniewicz, Manuela Caniça, Paulo Jorge Nogueira, Paulo André Fernandes, Vera Manageiro, Gabriel A Popescu, Roxana I Serban, Eva Schréterová, Slavka Litvová, Mária Štefkovicová, Jana Kolman, Irena Klavs, Aleš Korošec, Belén Aracil, Angel Asensio, María Pérez-Vázquez, Hanna Billström, Sofie Larsson, Jacqui S Reilly, Alan Johnson, and Susan Hopkins. 2019. “Attributable Deaths and Disability-adjusted Life-years Caused by Infections with Antibiotic-resistant Bacteria in the EU and the European Economic Area in 2015 : a Population-level Modelling Analysis.” Lancet Infectious Diseases 19 (1): 56–66.
Vancouver
1.
Cassini A, Högberg LD, Plachouras D, Quattrocchi A, Hoxha A, Simonsen GS, et al. Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis. LANCET INFECTIOUS DISEASES. 2019;19(1):56–66.
IEEE
[1]
A. Cassini et al., “Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis,” LANCET INFECTIOUS DISEASES, vol. 19, no. 1, pp. 56–66, 2019.
@article{8586609,
  abstract     = {Background: Infections due to antibiotic-resistant bacteria are threatening modern health care. However, estimating their incidence, complications, and attributable mortality is challenging. We aimed to estimate the burden of infections caused by antibiotic-resistant bacteria of public health concern in countries of the EU and European Economic Area (EEA) in 2015, measured in number of cases, attributable deaths, and disability-adjusted life-years (DALYs).
Methods: We estimated the incidence of infections with 16 antibiotic resistance–bacterium combinations from European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015 data that was country-corrected for population coverage. We multiplied the number of bloodstream infections (BSIs) by a conversion factor derived from the European Centre for Disease Prevention and Control point prevalence survey of health-care-associated infections in European acute care hospitals in 2011–12 to estimate the number of non-BSIs. We developed disease outcome models for five types of infection on the basis of systematic reviews of the literature.
Findings: From EARS-Net data collected between Jan 1, 2015, and Dec 31, 2015, we estimated 671 689 (95% uncertainty interval [UI] 583 148–763 966) infections with antibiotic-resistant bacteria, of which 63·5% (426 277 of 671 689) were associated with health care. These infections accounted for an estimated 33 110 (28 480–38 430) attributable deaths and 874 541 (768 837–989 068) DALYs. The burden for the EU and EEA was highest in infants (aged <1 year) and people aged 65 years or older, had increased since 2007, and was highest in Italy and Greece.
Interpretation: Our results present the health burden of five types of infection with antibiotic-resistant bacteria expressed, for the first time, in DALYs. The estimated burden of infections with antibiotic-resistant bacteria in the EU and EEA is substantial compared with that of other infectious diseases, and has increased since 2007. Our burden estimates provide useful information for public health decision-makers prioritising interventions for infectious diseases.},
  author       = {Cassini, Alessandro and Högberg, Liselotte Diaz and Plachouras, Diamantis and Quattrocchi, Annalisa and Hoxha, Ana and Simonsen, Gunnar Skov and Colomb-Cotinat, Mélanie and Kretzschmar, Mirjam E and Devleesschauwer, Brecht and Cecchini, Michele and Ouakrim, Driss Ait and Oliveira, Tiago Cravo and Struelens, Marc J and Suetens, Carl and Monnet, Dominique L and Strauss, Reinhild and Mertens, Karl and Struyf, Thomas and Catry, Boudewijn and Latour, Katrien and Ivanov, Ivan N and Dobreva, Elina G and Tambic Andraševic, Arjana and Soprek, Silvija and Budimir, Ana and Paphitou, Niki and Žemlicková, Helena and Schytte Olsen, Stefan and Wolff Sönksen, Ute and Märtin, Pille and Ivanova, Marina and Lyytikäinen, Outi and Jalava, Jari and Coignard, Bruno and Eckmanns, Tim and Abu Sin, Muna and Haller, Sebastian and Daikos, George L and Gikas, Achilleas and Tsiodras, Sotirios and Kontopidou, Flora and Tóth, Ákos and Hajdu, Ágnes and Guólaugsson, Ólafur and Kristinsson, Karl G and Murchan, Stephen and Burns, Karen and Pezzotti, Patrizio and Gagliotti, Carlo and Dumpis, Uga and Liuimiene, Agne and Perrin, Monique and Borg, Michael A and de Greeff, Sabine C and Monen, Jos CM and Koek, Mayke BG and Elstrøm, Petter and Zabicka, Dorota and Deptula, Aleksander and Hryniewicz, Waleria and Caniça, Manuela and Nogueira, Paulo Jorge and Fernandes, Paulo André and Manageiro, Vera and Popescu, Gabriel A and Serban, Roxana I and Schréterová, Eva and Litvová, Slavka and Štefkovicová, Mária and Kolman, Jana and Klavs, Irena and Korošec, Aleš and Aracil, Belén and Asensio, Angel and Pérez-Vázquez, María and Billström, Hanna and Larsson, Sofie and Reilly, Jacqui S and Johnson, Alan and Hopkins, Susan},
  issn         = {1473-3099},
  journal      = {LANCET INFECTIOUS DISEASES},
  keywords     = {CARBAPENEMASE-PRODUCING ENTEROBACTERIACEAE},
  language     = {eng},
  number       = {1},
  pages        = {56--66},
  title        = {Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015 : a population-level modelling analysis},
  url          = {http://dx.doi.org/10.1016/s1473-3099(18)30605-4},
  volume       = {19},
  year         = {2019},
}

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