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In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds

(2018) CHEMMEDCHEM. 13(23). p.2484-2487
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Abstract
The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC center dot H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*center dot H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.
Keywords
anti-atherogenic activity, atheromatosis, aurates, N-heterocyclic carbenes, platelet-activating factor, PLATELET-ACTIVATING-FACTOR, FACTOR PAF, RECEPTOR, POTENT, INFLAMMATION, ANTAGONIST, HISTAMINE, DISEASE, ATHEROSCLEROSIS, METASTASIS

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Chicago
Sioriki, Eleni, Ronan Lordan, Fady Nahra, Kristof Van Hecke, Ioannis Zabetakis, and Steven Nolan. 2018. “In Vitro Anti-atherogenic Properties of N-heterocyclic Carbene aurate(I) Compounds.” Chemmedchem 13 (23): 2484–2487.
APA
Sioriki, E., Lordan, R., Nahra, F., Van Hecke, K., Zabetakis, I., & Nolan, S. (2018). In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds. CHEMMEDCHEM, 13(23), 2484–2487.
Vancouver
1.
Sioriki E, Lordan R, Nahra F, Van Hecke K, Zabetakis I, Nolan S. In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds. CHEMMEDCHEM. 2018;13(23):2484–7.
MLA
Sioriki, Eleni et al. “In Vitro Anti-atherogenic Properties of N-heterocyclic Carbene aurate(I) Compounds.” CHEMMEDCHEM 13.23 (2018): 2484–2487. Print.
@article{8586426,
  abstract     = {The anti-atherogenic (anti-inflammatory) properties of various aurate(I) salts, of the general formula [NHC center dot H][AuCl2] (NHC=N-heterocyclic carbene) were investigated. The aurates were easily synthesized and obtained in analytically pure form. In addition, the biological activity of these compounds against atheromatosis via in vitro inhibition of platelet-activating factor (PAF)-induced platelet aggregation was probed. All complexes were found to possess anti-aggregatory properties in vitro with [IPr*center dot H][AuCl2] (6) being the most potent inhibitor of PAF at micromolar concentration. Based on our findings, we conclude that these simply assembled aurates are a very promising class of PAF inhibitors and anti-inflammatory drugs.},
  author       = {Sioriki, Eleni and Lordan, Ronan and Nahra, Fady and Van Hecke, Kristof and Zabetakis, Ioannis and Nolan, Steven},
  issn         = {1860-7179},
  journal      = {CHEMMEDCHEM},
  keywords     = {anti-atherogenic activity,atheromatosis,aurates,N-heterocyclic carbenes,platelet-activating factor,PLATELET-ACTIVATING-FACTOR,FACTOR PAF,RECEPTOR,POTENT,INFLAMMATION,ANTAGONIST,HISTAMINE,DISEASE,ATHEROSCLEROSIS,METASTASIS},
  language     = {eng},
  number       = {23},
  pages        = {2484--2487},
  title        = {In vitro anti-atherogenic properties of N-heterocyclic carbene aurate(I) compounds},
  url          = {http://dx.doi.org/10.1002/cmdc.201800601},
  volume       = {13},
  year         = {2018},
}

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