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Quality of life of patients with a colonic interposition postoesophagectomy

Delfien Coevoet, Elke Van Daele (UGent) , Wouter Willaert (UGent) , Wouter Huvenne (UGent) , Dirk Van de Putte (UGent) , Wim Ceelen (UGent) , Philippe Deron (UGent) , Piet Pattyn (UGent) and Yves Van Nieuwenhove (UGent)
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Abstract
OBJECTIVES: After oesophagectomy, stomach grafts are most frequently used to restore intestinal continuity. Less frequently, a colonic graft is used. There is quite a large body of literature addressing the functional outcome after gastric pull-up, but little is known about the functional results of colonic interposition (CI). The aim of this study was to assess the short-term outcomes and the long-term quality of life and function of the CI postoesophagectomy. METHODS: Between 2002 and 2016, we retrospectively collected data on 80 patients with CI from personal health records at the Ghent University hospital. We prospectively compared the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-OG25 and Swallowing Quality of Life (SWAL-QOL) questionnaire scores to the healthy reference group and the gastric tube (GT) group. RESULTS: The 30-day mortality rate was 5%. Anastomotic leakage occurred in 37.5% and stenosis in 20% of the patients. The median overall survival of all patients was 33.9months (95% confidence interval 8.3-59.4). The mean general health score of the CI patients was less than the healthy reference group but comparable to the GT group (CI=62.1 vs healthy reference group=71.2 vs GT=60). Fifty percent of the patients reported their health as good and 15% as very good. The mean functional results with a CI were better than with a GT. Compared to GT patients, CI patients had less dyspnoea, reflux and dysphagia, but they reported more food selection, diarrhoea and weight loss. CONCLUSIONS: Despite the high complication rate, the severity of the disease and the demanding operation, patients perceived themselves as being in good health and reported very good long-term functionality after CI. Clinical trial registration number B670201630635.
Keywords
Colonic interposition, Quality of life, Oesophagectomy, CAUSTIC STRICTURE MORTALITY, ESOPHAGEAL RECONSTRUCTION, ESOPHAGOGASTRIC JUNCTION, EORTC QLQ-OG25, CANCER, QUESTIONNAIRE, VALIDATION, GRAFT, REPLACEMENT, MORBIDITY

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MLA
Coevoet, Delfien et al. “Quality of Life of Patients with a Colonic Interposition Postoesophagectomy.” EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 55.6 (2019): 1113–1120. Print.
APA
Coevoet, D., Van Daele, E., Willaert, W., Huvenne, W., Van de Putte, D., Ceelen, W., Deron, P., et al. (2019). Quality of life of patients with a colonic interposition postoesophagectomy. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 55(6), 1113–1120. Presented at the 19th Belgian Surgical Week ; Annual congress of the Royal Belgian Society of Surgeons.
Chicago author-date
Coevoet, Delfien, Elke Van Daele, Wouter Willaert, Wouter Huvenne, Dirk Van de Putte, Wim Ceelen, Philippe Deron, Piet Pattyn, and Yves Van Nieuwenhove. 2019. “Quality of Life of Patients with a Colonic Interposition Postoesophagectomy.” European Journal of Cardio-thoracic Surgery 55 (6): 1113–1120.
Chicago author-date (all authors)
Coevoet, Delfien, Elke Van Daele, Wouter Willaert, Wouter Huvenne, Dirk Van de Putte, Wim Ceelen, Philippe Deron, Piet Pattyn, and Yves Van Nieuwenhove. 2019. “Quality of Life of Patients with a Colonic Interposition Postoesophagectomy.” European Journal of Cardio-thoracic Surgery 55 (6): 1113–1120.
Vancouver
1.
Coevoet D, Van Daele E, Willaert W, Huvenne W, Van de Putte D, Ceelen W, et al. Quality of life of patients with a colonic interposition postoesophagectomy. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2019;55(6):1113–20.
IEEE
[1]
D. Coevoet et al., “Quality of life of patients with a colonic interposition postoesophagectomy,” EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, vol. 55, no. 6, pp. 1113–1120, 2019.
@article{8585907,
  abstract     = {OBJECTIVES: After oesophagectomy, stomach grafts are most frequently used to restore intestinal continuity. Less frequently, a colonic graft is used. There is quite a large body of literature addressing the functional outcome after gastric pull-up, but little is known about the functional results of colonic interposition (CI). The aim of this study was to assess the short-term outcomes and the long-term quality of life and function of the CI postoesophagectomy. 
METHODS: Between 2002 and 2016, we retrospectively collected data on 80 patients with CI from personal health records at the Ghent University hospital. We prospectively compared the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30, EORTC QLQ-OG25 and Swallowing Quality of Life (SWAL-QOL) questionnaire scores to the healthy reference group and the gastric tube (GT) group. 
RESULTS: The 30-day mortality rate was 5%. Anastomotic leakage occurred in 37.5% and stenosis in 20% of the patients. The median overall survival of all patients was 33.9months (95% confidence interval 8.3-59.4). The mean general health score of the CI patients was less than the healthy reference group but comparable to the GT group (CI=62.1 vs healthy reference group=71.2 vs GT=60). Fifty percent of the patients reported their health as good and 15% as very good. The mean functional results with a CI were better than with a GT. Compared to GT patients, CI patients had less dyspnoea, reflux and dysphagia, but they reported more food selection, diarrhoea and weight loss. 
CONCLUSIONS: Despite the high complication rate, the severity of the disease and the demanding operation, patients perceived themselves as being in good health and reported very good long-term functionality after CI. 
Clinical trial registration number B670201630635.},
  author       = {Coevoet, Delfien and Van Daele, Elke and Willaert, Wouter and Huvenne, Wouter and Van de Putte, Dirk and Ceelen, Wim and Deron, Philippe and Pattyn, Piet and Van Nieuwenhove, Yves},
  issn         = {1010-7940},
  journal      = {EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY},
  keywords     = {Colonic interposition,Quality of life,Oesophagectomy,CAUSTIC STRICTURE MORTALITY,ESOPHAGEAL RECONSTRUCTION,ESOPHAGOGASTRIC JUNCTION,EORTC QLQ-OG25,CANCER,QUESTIONNAIRE,VALIDATION,GRAFT,REPLACEMENT,MORBIDITY},
  language     = {eng},
  location     = {Oostende, Belgium},
  number       = {6},
  pages        = {1113--1120},
  title        = {Quality of life of patients with a colonic interposition postoesophagectomy},
  url          = {http://dx.doi.org/10.1093/ejcts/ezy398},
  volume       = {55},
  year         = {2019},
}

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