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Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies

(2019) LEUKEMIA & LYMPHOMA. 60(5). p.1156-1163
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Abstract
In patients with hematologic malignancies, respiratory status may deteriorate during neutropenia recovery. This multicenter, observational study aims to evaluate granulocyte colony-stimulating factor (G-CSF) impact on respiratory status in critically ill neutropenic patients. Among 1011 critically ill patients with hematologic malignancies, 288 were neutropenic and included in this study. 201 (70%) did not receive G-CSF at day 1 or 2. After propensity score matching for the probability of receiving G-CSF at day 1 or 2, there was no association between G-CSF and respiratory deterioration at day 14 (OR =1.19; 95%CI (0.57-2.51); p = .64). Additional sensitivity analysis in patients admitted for acute respiratory failure showed similar results (OR =1.34; 95%CI (0.5-3.59); p = .57). Among patients who recovered from neutropenia, 75% experienced respiratory deterioration during neutropenia recovery. This study confirms that neutropenia recovery is a situation at risk of respiratory deterioration. However, whether G-CSF is an aggravating factor cannot be supported by our results.
Keywords
Hematologic malignancy, intensive care unit, G-CSF, neutropenia recovery, acute respiratory failure, propensity score, ACUTE LUNG INJURY, INTENSIVE-CARE-UNIT, G-CSF, FEBRILE NEUTROPENIA, DOUBLE-BLIND, PHASE-III, CHEMOTHERAPY, DETERIORATION, INFECTIONS, LEUKEMIA

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MLA
Mignard, Xavier, et al. “Granulocyte Colony-Stimulating Factor and Respiratory Status of Critically Ill Neutropenic Patients with Hematologic Malignancies.” LEUKEMIA & LYMPHOMA, vol. 60, no. 5, 2019, pp. 1156–63, doi:10.1080/10428194.2018.1516874.
APA
Mignard, X., Biard, L., Lemiale, V., Mokart, D., Pène, F., Kouatchet, A., … Zafrani, L. (2019). Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies. LEUKEMIA & LYMPHOMA, 60(5), 1156–1163. https://doi.org/10.1080/10428194.2018.1516874
Chicago author-date
Mignard, Xavier, Lucie Biard, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, et al. 2019. “Granulocyte Colony-Stimulating Factor and Respiratory Status of Critically Ill Neutropenic Patients with Hematologic Malignancies.” LEUKEMIA & LYMPHOMA 60 (5): 1156–63. https://doi.org/10.1080/10428194.2018.1516874.
Chicago author-date (all authors)
Mignard, Xavier, Lucie Biard, Virginie Lemiale, Djamel Mokart, Frédéric Pène, Achille Kouatchet, Julien Mayaux, François Vincent, Martine Nyunga, Fabrice Bruneel, Antoine Rabbat, Christine Lebert, Pierre Perez, Anne-Pascale Meert, Dominique Benoit, Rebecca Hamidfar, Michael Darmon, Elie Azoulay, and Lara Zafrani. 2019. “Granulocyte Colony-Stimulating Factor and Respiratory Status of Critically Ill Neutropenic Patients with Hematologic Malignancies.” LEUKEMIA & LYMPHOMA 60 (5): 1156–1163. doi:10.1080/10428194.2018.1516874.
Vancouver
1.
Mignard X, Biard L, Lemiale V, Mokart D, Pène F, Kouatchet A, et al. Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies. LEUKEMIA & LYMPHOMA. 2019;60(5):1156–63.
IEEE
[1]
X. Mignard et al., “Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies,” LEUKEMIA & LYMPHOMA, vol. 60, no. 5, pp. 1156–1163, 2019.
@article{8585835,
  abstract     = {{In patients with hematologic malignancies, respiratory status may deteriorate during neutropenia recovery. This multicenter, observational study aims to evaluate granulocyte colony-stimulating factor (G-CSF) impact on respiratory status in critically ill neutropenic patients. Among 1011 critically ill patients with hematologic malignancies, 288 were neutropenic and included in this study. 201 (70%) did not receive G-CSF at day 1 or 2. After propensity score matching for the probability of receiving G-CSF at day 1 or 2, there was no association between G-CSF and respiratory deterioration at day 14 (OR =1.19; 95%CI (0.57-2.51); p = .64). Additional sensitivity analysis in patients admitted for acute respiratory failure showed similar results (OR =1.34; 95%CI (0.5-3.59); p = .57). Among patients who recovered from neutropenia, 75% experienced respiratory deterioration during neutropenia recovery. This study confirms that neutropenia recovery is a situation at risk of respiratory deterioration. However, whether G-CSF is an aggravating factor cannot be supported by our results.}},
  author       = {{Mignard, Xavier and Biard, Lucie and Lemiale, Virginie and Mokart, Djamel and Pène, Frédéric and Kouatchet, Achille and Mayaux, Julien and Vincent, François and Nyunga, Martine and Bruneel, Fabrice and Rabbat, Antoine and Lebert, Christine and Perez, Pierre and Meert, Anne-Pascale and Benoit, Dominique and Hamidfar, Rebecca and Darmon, Michael and Azoulay, Elie and Zafrani, Lara}},
  issn         = {{1042-8194}},
  journal      = {{LEUKEMIA & LYMPHOMA}},
  keywords     = {{Hematologic malignancy,intensive care unit,G-CSF,neutropenia recovery,acute respiratory failure,propensity score,ACUTE LUNG INJURY,INTENSIVE-CARE-UNIT,G-CSF,FEBRILE NEUTROPENIA,DOUBLE-BLIND,PHASE-III,CHEMOTHERAPY,DETERIORATION,INFECTIONS,LEUKEMIA}},
  language     = {{eng}},
  number       = {{5}},
  pages        = {{1156--1163}},
  title        = {{Granulocyte colony-stimulating factor and respiratory status of critically ill neutropenic patients with hematologic malignancies}},
  url          = {{http://doi.org/10.1080/10428194.2018.1516874}},
  volume       = {{60}},
  year         = {{2019}},
}

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