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The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves : from field observations to toxicokinetics

(2019) ARCHIVES OF TOXICOLOGY. 93(2). p.293-310
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Abstract
A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13mg/kg feed) induced severe liver failure in 2- to 3-month-old beef calves. Symptoms disappeared by replacing the highly contaminated corn and by stimulating ruminal development via roughage administration. A multi-mycotoxin contamination was demonstrated in feed samples collected at 15 different veal farms in Belgium. DON was most prevalent, contaminating 80% of the roughage samples (mixed straw and maize silage; average concentration in positives: 637 +/- 621 mu g/kg, max. 1818 mu g/kg), and all feed concentrate samples (411 +/- 156 mu g/kg, max. 693 mu g/kg). In order to evaluate the impact of roughage provision and its associated ruminal development on the gastro-intestinal absorption and biodegradation of DON and its acetylated derivatives (3- and 15-ADON) in calves, a toxicokinetic study was performed with two ruminating and two non-ruminating male calves. Animals received in succession a bolus of DON (120 mu g/kg bodyweight (BW)), 15-ADON (50 mu g/kg BW), and 3-ADON (25 mu g/kg) by intravenous (IV) injection or per os (PO) in a cross-over design. The absolute oral bioavailability of DON was much higher in non-ruminating calves (50.7 +/- 33.0%) compared to ruminating calves (4.1 +/- 4.5%). Immediately following exposure, 3- and 15-ADON were hydrolysed to DON in ruminating calves. DON and its acetylated metabolites were mainly metabolized to DON-3-glucuronide, however, also small amounts of DON-15-glucuronide were detected in urine. DON degradation to deepoxy-DON (DOM-1) was only observed to a relevant extent in ruminating calves. Consequently, toxicity of DON in calves is closely related to roughage provision and the associated stage of ruminal development.
Keywords
Biodegradation, Calf, Deoxynivalenol, 3-and 15-Acetyldeoxynivalenol, Mycotoxin, Toxicokinetics, TOXIN-CONTAMINATED WHEAT, FUSARIUM MYCOTOXINS, VEAL CALVES, CARRY-OVER, FEED, FOOD, BIOAVAILABILITY, TRICHOTHECENES, METABOLISM, CATTLE

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MLA
Valgaeren, Bonnie et al. “The Role of Roughage Provision on the Absorption and Disposition of the Mycotoxin Deoxynivalenol and Its Acetylated Derivatives in Calves : from Field Observations to Toxicokinetics.” ARCHIVES OF TOXICOLOGY 93.2 (2019): 293–310. Print.
APA
Valgaeren, B., Théron, L., Croubels, S., Devreese, M., De Baere, S., Van Pamel, E., Daeseleire, E., et al. (2019). The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves : from field observations to toxicokinetics. ARCHIVES OF TOXICOLOGY, 93(2), 293–310.
Chicago author-date
Valgaeren, Bonnie, Léonard Théron, Siska Croubels, Mathias Devreese, Siegrid De Baere, Els Van Pamel, Els Daeseleire, et al. 2019. “The Role of Roughage Provision on the Absorption and Disposition of the Mycotoxin Deoxynivalenol and Its Acetylated Derivatives in Calves : from Field Observations to Toxicokinetics.” Archives of Toxicology 93 (2): 293–310.
Chicago author-date (all authors)
Valgaeren, Bonnie, Léonard Théron, Siska Croubels, Mathias Devreese, Siegrid De Baere, Els Van Pamel, Els Daeseleire, Marthe De Boevre, Sarah De Saeger, Arnau Vidal Corominas, José Diana Di Mavungu, Philipp Fruhmann, Gerhard Adam, Alfons Callebaut, Calixte Bayrou, Vincent Frisée, Anne-Sophie Rao, Emilie Knapp, Arnaud Sartelet, Bart Pardon, Piet Deprez, and Gunther Antonissen. 2019. “The Role of Roughage Provision on the Absorption and Disposition of the Mycotoxin Deoxynivalenol and Its Acetylated Derivatives in Calves : from Field Observations to Toxicokinetics.” Archives of Toxicology 93 (2): 293–310.
Vancouver
1.
Valgaeren B, Théron L, Croubels S, Devreese M, De Baere S, Van Pamel E, et al. The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves : from field observations to toxicokinetics. ARCHIVES OF TOXICOLOGY. 2019;93(2):293–310.
IEEE
[1]
B. Valgaeren et al., “The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves : from field observations to toxicokinetics,” ARCHIVES OF TOXICOLOGY, vol. 93, no. 2, pp. 293–310, 2019.
@article{8585027,
  abstract     = {A clinical case in Belgium demonstrated that feeding a feed concentrate containing considerable levels of deoxynivalenol (DON, 1.13mg/kg feed) induced severe liver failure in 2- to 3-month-old beef calves. Symptoms disappeared by replacing the highly contaminated corn and by stimulating ruminal development via roughage administration. A multi-mycotoxin contamination was demonstrated in feed samples collected at 15 different veal farms in Belgium. DON was most prevalent, contaminating 80% of the roughage samples (mixed straw and maize silage; average concentration in positives: 637 +/- 621 mu g/kg, max. 1818 mu g/kg), and all feed concentrate samples (411 +/- 156 mu g/kg, max. 693 mu g/kg). In order to evaluate the impact of roughage provision and its associated ruminal development on the gastro-intestinal absorption and biodegradation of DON and its acetylated derivatives (3- and 15-ADON) in calves, a toxicokinetic study was performed with two ruminating and two non-ruminating male calves. Animals received in succession a bolus of DON (120 mu g/kg bodyweight (BW)), 15-ADON (50 mu g/kg BW), and 3-ADON (25 mu g/kg) by intravenous (IV) injection or per os (PO) in a cross-over design. The absolute oral bioavailability of DON was much higher in non-ruminating calves (50.7 +/- 33.0%) compared to ruminating calves (4.1 +/- 4.5%). Immediately following exposure, 3- and 15-ADON were hydrolysed to DON in ruminating calves. DON and its acetylated metabolites were mainly metabolized to DON-3-glucuronide, however, also small amounts of DON-15-glucuronide were detected in urine. DON degradation to deepoxy-DON (DOM-1) was only observed to a relevant extent in ruminating calves. Consequently, toxicity of DON in calves is closely related to roughage provision and the associated stage of ruminal development.},
  author       = {Valgaeren, Bonnie and Théron, Léonard and Croubels, Siska and Devreese, Mathias and De Baere, Siegrid and Van Pamel, Els and Daeseleire, Els and De Boevre, Marthe and De Saeger, Sarah and Vidal Corominas, Arnau and Diana Di Mavungu, José and Fruhmann, Philipp and Adam, Gerhard and Callebaut, Alfons and Bayrou, Calixte and Frisée, Vincent and Rao, Anne-Sophie and Knapp, Emilie and Sartelet, Arnaud and Pardon, Bart and Deprez, Piet and Antonissen, Gunther},
  issn         = {0340-5761},
  journal      = {ARCHIVES OF TOXICOLOGY},
  keywords     = {Biodegradation,Calf,Deoxynivalenol,3-and 15-Acetyldeoxynivalenol,Mycotoxin,Toxicokinetics,TOXIN-CONTAMINATED WHEAT,FUSARIUM MYCOTOXINS,VEAL CALVES,CARRY-OVER,FEED,FOOD,BIOAVAILABILITY,TRICHOTHECENES,METABOLISM,CATTLE},
  language     = {eng},
  number       = {2},
  pages        = {293--310},
  title        = {The role of roughage provision on the absorption and disposition of the mycotoxin deoxynivalenol and its acetylated derivatives in calves : from field observations to toxicokinetics},
  url          = {http://dx.doi.org/10.1007/s00204-018-2368-8},
  volume       = {93},
  year         = {2019},
}

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