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Spider peptide toxins as leads for drug development

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Organization
Abstract
Venomous animals use a highly complex cocktails of proteins, peptides and small molecules to subdue and kill their prey. As such, venoms represent highly valuable combinatorial peptide libraries, displaying an extensive range of pharmacological activities, honed by natural selection. Modern analytical technologies enable us to take full advantage of this vast pharmacological cornucopia in the hunt for novel drug leads. Spider venoms represent a resource of several million peptides, which selectively target specific subtypes of ion channels. Structure function studies of spider toxins are leading not only to the discovery of novel molecules, but also to novel therapeutic routes for cardiovascular diseases, cancer, neuromuscular diseases, pain and to a variety of other pathological conditions. This review presents an overview of spider peptide toxins as candidates for therapeutics and focuses on their applications in the discovery of novel mechanisms of analgesia.
Keywords
drug discovery, ion channels, mass spectrometry, pain, peptide toxins, spider venom

Citation

Please use this url to cite or link to this publication:

Chicago
Escoubas, Pierre, and Frank Bosmans. 2007. “Spider Peptide Toxins as Leads for Drug Development.” Expert Opinion on Drug Discovery 2 (6): 823–835.
APA
Escoubas, Pierre, & Bosmans, F. (2007). Spider peptide toxins as leads for drug development. EXPERT OPINION ON DRUG DISCOVERY, 2(6), 823–835.
Vancouver
1.
Escoubas P, Bosmans F. Spider peptide toxins as leads for drug development. EXPERT OPINION ON DRUG DISCOVERY. 2007;2(6):823–35.
MLA
Escoubas, Pierre, and Frank Bosmans. “Spider Peptide Toxins as Leads for Drug Development.” EXPERT OPINION ON DRUG DISCOVERY 2.6 (2007): 823–835. Print.
@article{8584539,
  abstract     = {Venomous animals use a highly complex cocktails of proteins, peptides and small molecules to subdue and kill their prey. As such, venoms represent highly valuable combinatorial peptide libraries, displaying an extensive range of pharmacological activities, honed by natural selection. Modern analytical technologies enable us to take full advantage of this vast pharmacological cornucopia in the hunt for novel drug leads. Spider venoms represent a resource of several million peptides, which selectively target specific subtypes of ion channels. Structure function studies of spider toxins are leading not only to the discovery of novel molecules, but also to novel therapeutic routes for cardiovascular diseases, cancer, neuromuscular diseases, pain and to a variety of other pathological conditions. This review presents an overview of spider peptide toxins as candidates for therapeutics and focuses on their applications in the discovery of novel mechanisms of analgesia.},
  author       = {Escoubas, Pierre and Bosmans, Frank},
  issn         = {1746-0441},
  journal      = {EXPERT OPINION ON DRUG DISCOVERY},
  keywords     = {drug discovery,ion channels,mass spectrometry,pain,peptide toxins,spider venom},
  language     = {eng},
  number       = {6},
  pages        = {823--835},
  title        = {Spider peptide toxins as leads for drug development},
  url          = {http://dx.doi.org/10.1517/17460441.2.6.823},
  volume       = {2},
  year         = {2007},
}

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