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The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps

(2019) RHINOLOGY. 57(1). p.32-42
Author
Organization
Abstract
Background: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic inflammatory disease of the nose and paranasal sinuses that is classified according to the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. Methods: This paper reports the methodology and descriptive results of the Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort. We established a large CRS cohort within the GALEN consortium (European FP6 research initiative) to identify inflammatory endotypes, the natural disease course, and its impact on health-related quality of life (HRQoL). Detailed information on the impact of CRS on HRQoL, comorbidity incidence, objective disease measures, and medical and surgical treatments were collected. Results: This multicentre cross-sectional case-control study recruited 935 adults (869 eligible for analysis: 237 CRSsNP; 445 CRSwNP; 187 controls [reference group]). Comorbidities such as asthma, allergy, eczema, food allergy, urticaria, and chronic obstructive pulmonary disease were significantly more frequent in CRS patients. Nasal corticosteroids, antibiotics, and oral corticosteroids were the most common treatments. Significantly more CRSwNP patients reported previous sinonasal surgery. Conclusions: This study provides detailed information that facilitates studying CRS and its main phenotypes. However, patient distribution of this study does not necessarily reflect disease distribution in the general population.
Keywords
cohort studies, cross-sectional studies, nasal polyps, rhinitis, sinusitis, QUALITY-OF-LIFE, NATIONAL COMPARATIVE AUDIT, IMPACT, PREVALENCE, ASPIRIN, SYMPTOMS, SURGERY, SF-36

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MLA
Khan, Asif, et al. “The Global Allergy and Asthma European Network (GALEN) Rhinosinusitis Cohort : A Large European Cross-Sectional Study of Chronic Rhinosinusitis Patients with and without Nasal Polyps.” RHINOLOGY, vol. 57, no. 1, 2019, pp. 32–42, doi:10.4193/rhin17.255.
APA
Khan, A., VANDEPLAS, G., Huynh, T. M. T., Joish, V. N., Mannent, L., Tomassen, P., … Bachert, C. (2019). The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps. RHINOLOGY, 57(1), 32–42. https://doi.org/10.4193/rhin17.255
Chicago author-date
Khan, Asif, GRIET VANDEPLAS, Thi Minh Thao Huynh, Vijay N. Joish, Leda Mannent, Peter Tomassen, Thibaut Van Zele, et al. 2019. “The Global Allergy and Asthma European Network (GALEN) Rhinosinusitis Cohort : A Large European Cross-Sectional Study of Chronic Rhinosinusitis Patients with and without Nasal Polyps.” RHINOLOGY 57 (1): 32–42. https://doi.org/10.4193/rhin17.255.
Chicago author-date (all authors)
Khan, Asif, GRIET VANDEPLAS, Thi Minh Thao Huynh, Vijay N. Joish, Leda Mannent, Peter Tomassen, Thibaut Van Zele, Lars-Olaf Cardell, Julia Arebro, Heidi Olze, Ulrike Foerster-Ruhrmann, Marek L. Kowalski, Agnieszka Olszewska-Ziaber, Gabriële Holtappels, Nathalie De Ruyck, Cornelis van Drunen, Joaquim Mullol, Peter W. Hellings, Valerie Hox, Elina M. Toskala, Glenis Scadding, Valerie Lund, Wytske Fokkens, and Claus Bachert. 2019. “The Global Allergy and Asthma European Network (GALEN) Rhinosinusitis Cohort : A Large European Cross-Sectional Study of Chronic Rhinosinusitis Patients with and without Nasal Polyps.” RHINOLOGY 57 (1): 32–42. doi:10.4193/rhin17.255.
Vancouver
1.
Khan A, VANDEPLAS G, Huynh TMT, Joish VN, Mannent L, Tomassen P, et al. The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps. RHINOLOGY. 2019;57(1):32–42.
IEEE
[1]
A. Khan et al., “The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps,” RHINOLOGY, vol. 57, no. 1, pp. 32–42, 2019.
@article{8584426,
  abstract     = {Background: Chronic rhinosinusitis (CRS) is a common yet under-recognised chronic inflammatory disease of the nose and paranasal sinuses that is classified according to the presence (CRSwNP) or absence (CRSsNP) of nasal polyps. 
Methods: This paper reports the methodology and descriptive results of the Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort. We established a large CRS cohort within the GALEN consortium (European FP6 research initiative) to identify inflammatory endotypes, the natural disease course, and its impact on health-related quality of life (HRQoL). Detailed information on the impact of CRS on HRQoL, comorbidity incidence, objective disease measures, and medical and surgical treatments were collected. 
Results: This multicentre cross-sectional case-control study recruited 935 adults (869 eligible for analysis: 237 CRSsNP; 445 CRSwNP; 187 controls [reference group]). Comorbidities such as asthma, allergy, eczema, food allergy, urticaria, and chronic obstructive pulmonary disease were significantly more frequent in CRS patients. Nasal corticosteroids, antibiotics, and oral corticosteroids were the most common treatments. Significantly more CRSwNP patients reported previous sinonasal surgery. 
Conclusions: This study provides detailed information that facilitates studying CRS and its main phenotypes. However, patient distribution of this study does not necessarily reflect disease distribution in the general population.},
  author       = {Khan, Asif and VANDEPLAS, GRIET and Huynh, Thi Minh Thao and Joish, Vijay N. and Mannent, Leda and Tomassen, Peter and Van Zele, Thibaut and Cardell, Lars-Olaf and Arebro, Julia and Olze, Heidi and Foerster-Ruhrmann, Ulrike and Kowalski, Marek L. and Olszewska-Ziaber, Agnieszka and Holtappels, Gabriële and De Ruyck, Nathalie and van Drunen, Cornelis and Mullol, Joaquim and Hellings, Peter W. and Hox, Valerie and Toskala, Elina M. and Scadding, Glenis and Lund, Valerie and Fokkens, Wytske and Bachert, Claus},
  issn         = {0300-0729},
  journal      = {RHINOLOGY},
  keywords     = {cohort studies,cross-sectional studies,nasal polyps,rhinitis,sinusitis,QUALITY-OF-LIFE,NATIONAL COMPARATIVE AUDIT,IMPACT,PREVALENCE,ASPIRIN,SYMPTOMS,SURGERY,SF-36},
  language     = {eng},
  number       = {1},
  pages        = {32--42},
  title        = {The Global Allergy and Asthma European Network (GALEN) rhinosinusitis cohort : a large European cross-sectional study of chronic rhinosinusitis patients with and without nasal polyps},
  url          = {http://dx.doi.org/10.4193/rhin17.255},
  volume       = {57},
  year         = {2019},
}

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