Advanced search
1 file | 3.12 MB

Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide

(2018) NATURE MATERIALS. 17(11). p.971-977
Author
Organization
Abstract
Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain-Barre syndrome' and congenital Zika syndrome(2). As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brain. Here, we have engineered a brain-penetrating peptide that works against Zika virus and other mosquito-borne viruses. We evaluated the therapeutic efficacy of the peptide in a lethal Zika virus mouse model exhibiting systemic and brain infection. Therapeutic treatment protected against mortality and markedly reduced clinical symptoms, viral loads and neuroinflammation, as well as mitigated microgliosis, neurodegeneration and brain damage. In addition to controlling systemic infection, the peptide crossed the blood-brain barrier to reduce viral loads in the brain and protected against Zikavirus-induced blood-brain barrier injury. Our findings demonstrate how engineering strategies can be applied to develop peptide therapeutics and support the potential of a brain-penetrating peptide to treat neurotropic viral infections.
Keywords
HUMAN-ANTIBODIES, NERVOUS-SYSTEM, LIPID VESICLES, DENGUE, DISEASE, MICE

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 3.12 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Jackman, Joshua A, Vivian V Costa, Soohyun Park, Ana Luiza CV Real, Jae Hyeon Park, Pablo L Cardozo, Abdul Rahim Ferhan, et al. 2018. “Therapeutic Treatment of Zika Virus Infection Using a Brain-penetrating Antiviral Peptide.” Nature Materials 17 (11): 971–977.
APA
Jackman, J. A., Costa, V. V., Park, S., Real, A. L. C., Park, J. H., Cardozo, P. L., Ferhan, A. R., et al. (2018). Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide. NATURE MATERIALS, 17(11), 971–977.
Vancouver
1.
Jackman JA, Costa VV, Park S, Real ALC, Park JH, Cardozo PL, et al. Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide. NATURE MATERIALS. 2018;17(11):971–7.
MLA
Jackman, Joshua A, Vivian V Costa, Soohyun Park, et al. “Therapeutic Treatment of Zika Virus Infection Using a Brain-penetrating Antiviral Peptide.” NATURE MATERIALS 17.11 (2018): 971–977. Print.
@article{8583241,
  abstract     = {Zika virus is a mosquito-borne virus that is associated with neurodegenerative diseases, including Guillain-Barre syndrome' and congenital Zika syndrome(2). As Zika virus targets the nervous system, there is an urgent need to develop therapeutic strategies that inhibit Zika virus infection in the brain. Here, we have engineered a brain-penetrating peptide that works against Zika virus and other mosquito-borne viruses. We evaluated the therapeutic efficacy of the peptide in a lethal Zika virus mouse model exhibiting systemic and brain infection. Therapeutic treatment protected against mortality and markedly reduced clinical symptoms, viral loads and neuroinflammation, as well as mitigated microgliosis, neurodegeneration and brain damage. In addition to controlling systemic infection, the peptide crossed the blood-brain barrier to reduce viral loads in the brain and protected against Zikavirus-induced blood-brain barrier injury. Our findings demonstrate how engineering strategies can be applied to develop peptide therapeutics and support the potential of a brain-penetrating peptide to treat neurotropic viral infections.},
  author       = {Jackman, Joshua A and Costa, Vivian V and Park, Soohyun and Real, Ana Luiza CV and Park, Jae Hyeon and Cardozo, Pablo L and Ferhan, Abdul Rahim and Olmo, Isabella G and Moreira, Thaiane P and Bambirra, Jordana L and Queiroz, Victoria F and Queiroz-Junior, Celso M and Foureaux, Giselle and Souza, Danielle G and Ribeiro, Fabiola M and Yoon, Bo Kyeong and Wynendaele, Evelien and De Spiegeleer, Bart and Teixeira, Mauro M and Cho, Nam-Joon},
  issn         = {1476-1122},
  journal      = {NATURE MATERIALS},
  language     = {eng},
  number       = {11},
  pages        = {971--977},
  title        = {Therapeutic treatment of Zika virus infection using a brain-penetrating antiviral peptide},
  url          = {http://dx.doi.org/10.1038/s41563-018-0194-2},
  volume       = {17},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: