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DoRes within CellMissy : dose-response analysis on cell migration and related data

Gwendolien Sergeant (UGent) , Lennart Martens (UGent) , Marleen Van Troys (UGent) and Paola Masuzzo (UGent)
(2019) BIOINFORMATICS. 35(4). p.696-697
Author
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Abstract
In cancer research, cell-based assays are used to assess cell migration and invasion. The major bottleneck is the lack of automated tools to visualize and analyse the large amounts of biological dose-response data produced. To address this challenge, we have developed an automated and free software package for dose-response analyses, DoRes, which is released as an add-on of the freely available and open-source tool CellMissy, dedicated to the management and analysis of cell migration data. DoRes implements non-linear curve fitting functionality into a robust, user-friendly and flexible software package with the possibility of importing a tabular file or starting from a cell migration experiment. We demonstrate the ability of the software by analysing public dose-response data and a typical cell migration experiment, and show that the extracted dose-response parameters and the calculated statistical values are consistently comparable to those of the widely used, commercial software GraphPad Prism.

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Please use this url to cite or link to this publication:

MLA
Sergeant, Gwendolien, et al. “DoRes within CellMissy : Dose-Response Analysis on Cell Migration and Related Data.” BIOINFORMATICS, vol. 35, no. 4, 2019, pp. 696–97.
APA
Sergeant, G., Martens, L., Van Troys, M., & Masuzzo, P. (2019). DoRes within CellMissy : dose-response analysis on cell migration and related data. BIOINFORMATICS, 35(4), 696–697.
Chicago author-date
Sergeant, Gwendolien, Lennart Martens, Marleen Van Troys, and Paola Masuzzo. 2019. “DoRes within CellMissy : Dose-Response Analysis on Cell Migration and Related Data.” BIOINFORMATICS 35 (4): 696–97.
Chicago author-date (all authors)
Sergeant, Gwendolien, Lennart Martens, Marleen Van Troys, and Paola Masuzzo. 2019. “DoRes within CellMissy : Dose-Response Analysis on Cell Migration and Related Data.” BIOINFORMATICS 35 (4): 696–697.
Vancouver
1.
Sergeant G, Martens L, Van Troys M, Masuzzo P. DoRes within CellMissy : dose-response analysis on cell migration and related data. BIOINFORMATICS. 2019;35(4):696–7.
IEEE
[1]
G. Sergeant, L. Martens, M. Van Troys, and P. Masuzzo, “DoRes within CellMissy : dose-response analysis on cell migration and related data,” BIOINFORMATICS, vol. 35, no. 4, pp. 696–697, 2019.
@article{8583211,
  abstract     = {In cancer research, cell-based assays are used to assess cell migration and invasion. The major bottleneck is the lack of automated tools to visualize and analyse the large amounts of biological dose-response data produced. To address this challenge, we have developed an automated and free software package for dose-response analyses, DoRes, which is released as an add-on of the freely available and open-source tool CellMissy, dedicated to the management and analysis of cell migration data. DoRes implements non-linear curve fitting functionality into a robust, user-friendly and flexible software package with the possibility of importing a tabular file or starting from a cell migration experiment. We demonstrate the ability of the software by analysing public dose-response data and a typical cell migration experiment, and show that the extracted dose-response parameters and the calculated statistical values are consistently comparable to those of the widely used, commercial software GraphPad Prism.},
  author       = {Sergeant, Gwendolien and Martens, Lennart and Van Troys, Marleen and Masuzzo, Paola},
  issn         = {1367-4803},
  journal      = {BIOINFORMATICS},
  language     = {eng},
  number       = {4},
  pages        = {696--697},
  title        = {DoRes within CellMissy : dose-response analysis on cell migration and related data},
  url          = {http://dx.doi.org/10.1093/bioinformatics/bty634},
  volume       = {35},
  year         = {2019},
}

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