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Comparison between direct electrical and optogenetic subthalamic nucleus stimulation

Ruben Schoeters (UGent) , Thomas Tarnaud (UGent) , Wout Joseph (UGent) , Luc Martens (UGent) , Robrecht Raedt (UGent) and Emmeric Tanghe (UGent)
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Abstract
Subthalamic nucleus deep brain stimulation is a treatment for Parkinson’s disease. In this study, a computational model of a plateau-potential generating subthalamic nucleus neuron (Otsuka-model) and a four-state ChR2(H134R) model (Williams-model) are combined, in order to compare electrical and optogenetic neuromodulation capabilities. The impact of the stimulation modality (optogenetic or electric) on firing rates, strength-duration curves and action potential shape is investigated. First, in contrast to electrical stimulation, mean instantaneous firing rates saturate for optical stimulation at intensities higher than 0.1 W/cm2. Second, rheobase and chronaxie are 175% and 9.6% larger in optogenetic stimulation compared to electrical stimulation, respectively. Third, action potential shape is not significantly impacted by the neurostimulation modality.
Keywords
Electrical stimulation, Firing, Stimulated emission, Optical saturation, Optical pulses, Computational modeling, Neuromodulation, Optogenetics, subthalamic nucleus, computational modeling, Otsuka-model, Channelrhodopsin-2 (H134R)

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Citation

Please use this url to cite or link to this publication:

Chicago
Schoeters, Ruben, Thomas Tarnaud, Wout Joseph, Luc Martens, Robrecht Raedt, and Emmeric Tanghe. 2018. “Comparison Between Direct Electrical and Optogenetic Subthalamic Nucleus Stimulation.” In 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med), 49–50. New York, NY, USA: IEEE.
APA
Schoeters, R., Tarnaud, T., Joseph, W., Martens, L., Raedt, R., & Tanghe, E. (2018). Comparison between direct electrical and optogenetic subthalamic nucleus stimulation. 2018 EMF-Med 1st world conference on biomedical applications of electromagnetic fields (EMF-Med) (pp. 49–50). Presented at the 1st World conference on Biomedical Applications of Electromagnetic Fields (EMF-Med 2018), New York, NY, USA: IEEE.
Vancouver
1.
Schoeters R, Tarnaud T, Joseph W, Martens L, Raedt R, Tanghe E. Comparison between direct electrical and optogenetic subthalamic nucleus stimulation. 2018 EMF-Med 1st world conference on biomedical applications of electromagnetic fields (EMF-Med). New York, NY, USA: IEEE; 2018. p. 49–50.
MLA
Schoeters, Ruben, Thomas Tarnaud, Wout Joseph, et al. “Comparison Between Direct Electrical and Optogenetic Subthalamic Nucleus Stimulation.” 2018 EMF-Med 1st World Conference on Biomedical Applications of Electromagnetic Fields (EMF-Med). New York, NY, USA: IEEE, 2018. 49–50. Print.
@inproceedings{8583179,
  abstract     = {Subthalamic nucleus deep brain stimulation is a treatment for Parkinson{\textquoteright}s disease. In this study, a computational model of a plateau-potential generating subthalamic nucleus neuron (Otsuka-model) and a four-state ChR2(H134R) model (Williams-model) are combined, in order to compare electrical and optogenetic neuromodulation capabilities. The impact of the stimulation modality (optogenetic or electric) on firing rates, strength-duration curves and action potential shape is investigated. First, in contrast to electrical stimulation, mean instantaneous firing rates saturate for optical stimulation at intensities higher than 0.1 W/cm2. Second, rheobase and chronaxie are 175\% and 9.6\% larger in optogenetic stimulation compared to electrical stimulation, respectively. Third, action potential shape is not significantly impacted by the neurostimulation modality.},
  author       = {Schoeters, Ruben and Tarnaud, Thomas and Joseph, Wout and Martens, Luc and Raedt, Robrecht and Tanghe, Emmeric},
  booktitle    = {2018 EMF-Med 1st world conference on biomedical applications of electromagnetic fields (EMF-Med)},
  isbn         = {9781538659229},
  keyword      = {Electrical stimulation,Firing,Stimulated emission,Optical saturation,Optical pulses,Computational modeling,Neuromodulation,Optogenetics,subthalamic nucleus,computational modeling,Otsuka-model,Channelrhodopsin-2 (H134R)},
  language     = {eng},
  location     = {Split, Croatia},
  pages        = {49--50},
  publisher    = {IEEE},
  title        = {Comparison between direct electrical and optogenetic subthalamic nucleus stimulation},
  url          = {http://dx.doi.org/10.23919/EMF-MED.2018.8526018},
  year         = {2018},
}

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