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Developmental and functional heterogeneity of monocytes

(2018) IMMUNITY. 49(4). p.595-613
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Abstract
Novel experimental approaches such as fate-mapping and single-cell analysis have brought fresh insight into monocyte development and function over the past decade and helped redefine the monocyte field. Monocytes are now known to consist of multiple subsets generated through distinct developmental pathways with diverse functional specializations. Their fates under homeostatic conditions include the accumulation in peripheral reservoirs and the engraftment into certain resident macrophage pools. Under pathological conditions, monocytes acquire inflammatory effector functions, but can also develop regulatory properties essential for tissue repair. Importantly, monocytes recruited during inflammation are often functionally distinct from resident macrophages or conventional dendritic cells. Here we outline emerging concepts in monocyte heterogeneity, emergency monopoiesis, and trained immunity and discuss how these bring new perspectives to monocyte research.
Keywords
TISSUE-RESIDENT MACROPHAGES, HEMATOPOIETIC STEM-CELLS, TUMOR-ASSOCIATED, MACROPHAGES, COLONY-STIMULATING FACTOR, CENTRAL-NERVOUS-SYSTEM, CYTOKINE, GM-CSF, ACUTE MYOCARDIAL-INFARCTION, INDUCED GRANULOMA-FORMATION, STEADY-STATE CONDITIONS, MOUSE BONE-MARROW

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Citation

Please use this url to cite or link to this publication:

Chicago
Guilliams, Martin, Alexander Mildner, and Simon Yona. 2018. “Developmental and Functional Heterogeneity of Monocytes.” Immunity 49 (4): 595–613.
APA
Guilliams, M., Mildner, A., & Yona, S. (2018). Developmental and functional heterogeneity of monocytes. IMMUNITY, 49(4), 595–613.
Vancouver
1.
Guilliams M, Mildner A, Yona S. Developmental and functional heterogeneity of monocytes. IMMUNITY. 2018;49(4):595–613.
MLA
Guilliams, Martin, Alexander Mildner, and Simon Yona. “Developmental and Functional Heterogeneity of Monocytes.” IMMUNITY 49.4 (2018): 595–613. Print.
@article{8583114,
  abstract     = {Novel experimental approaches such as fate-mapping and single-cell analysis have brought fresh insight into monocyte development and function over the past decade and helped redefine the monocyte field. Monocytes are now known to consist of multiple subsets generated through distinct developmental pathways with diverse functional specializations. Their fates under homeostatic conditions include the accumulation in peripheral reservoirs and the engraftment into certain resident macrophage pools. Under pathological conditions, monocytes acquire inflammatory effector functions, but can also develop regulatory properties essential for tissue repair. Importantly, monocytes recruited during inflammation are often functionally distinct from resident macrophages or conventional dendritic cells. Here we outline emerging concepts in monocyte heterogeneity, emergency monopoiesis, and trained immunity and discuss how these bring new perspectives to monocyte research.},
  author       = {Guilliams, Martin and Mildner, Alexander and Yona, Simon},
  issn         = {1074-7613},
  journal      = {IMMUNITY},
  keywords     = {TISSUE-RESIDENT MACROPHAGES,HEMATOPOIETIC STEM-CELLS,TUMOR-ASSOCIATED,MACROPHAGES,COLONY-STIMULATING FACTOR,CENTRAL-NERVOUS-SYSTEM,CYTOKINE,GM-CSF,ACUTE MYOCARDIAL-INFARCTION,INDUCED GRANULOMA-FORMATION,STEADY-STATE CONDITIONS,MOUSE BONE-MARROW},
  language     = {eng},
  number       = {4},
  pages        = {595--613},
  title        = {Developmental and functional heterogeneity of monocytes},
  url          = {http://dx.doi.org/10.1016/j.immuni.2018.10.005},
  volume       = {49},
  year         = {2018},
}

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