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Abstract
Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissue- supportive functions. The current paradigm dictates that intestinal macrophages are continuously replaced by incoming monocytes that acquire a pro-inflammatory or tissue-protective signature. Here, we identify a self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood. Gene expression and imaging studies of self-maintaining macrophages revealed distinct transcriptional profiles that reflect their unique localization (i.e., closely positioned to blood vessels, submucosal and myenteric plexus, Paneth cells, and Peyer's patches). Depletion of self-maintaining macrophages resulted in morphological abnormalities in the submucosal vasculature and loss of enteric neurons, leading to vascular leakage, impaired secretion, and reduced intestinal motility. These results provide critical insights in intestinal macrophage heterogeneity and demonstrate the strategic role of self-maintaining macrophages in gut homeostasis and intestinal physiology.
Keywords
TISSUE MACROPHAGES, EXPRESSION PROFILES, ADULT MICROGLIA, PEYERS PATCH, CELL, MONOCYTES, RESPONSES, IDENTITY, REVEALS, ORIGINS

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Chicago
De Schepper, Sebastiaan, Simon Verheijden, Javier Aguilera-Lizarraga, Maria Francesca Viola, Werend Boesmans, Nathalie Stakenborg, Iryna Voytyuk, et al. 2018. “Self-maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.” Cell 175 (2): 400–415.
APA
De Schepper, S., Verheijden, S., Aguilera-Lizarraga, J., Viola, M. F., Boesmans, W., Stakenborg, N., Voytyuk, I., et al. (2018). Self-maintaining gut macrophages are essential for intestinal homeostasis. CELL, 175(2), 400–415.
Vancouver
1.
De Schepper S, Verheijden S, Aguilera-Lizarraga J, Viola MF, Boesmans W, Stakenborg N, et al. Self-maintaining gut macrophages are essential for intestinal homeostasis. CELL. 2018;175(2):400–15.
MLA
De Schepper, Sebastiaan et al. “Self-maintaining Gut Macrophages Are Essential for Intestinal Homeostasis.” CELL 175.2 (2018): 400–415. Print.
@article{8583091,
  abstract     = {Macrophages are highly heterogeneous tissue-resident immune cells that perform a variety of tissue- supportive functions. The current paradigm dictates that intestinal macrophages are continuously replaced by incoming monocytes that acquire a pro-inflammatory or tissue-protective signature. Here, we identify a self-maintaining population of macrophages that arise from both embryonic precursors and adult bone marrow-derived monocytes and persists throughout adulthood. Gene expression and imaging studies of self-maintaining macrophages revealed distinct transcriptional profiles that reflect their unique localization (i.e., closely positioned to blood vessels, submucosal and myenteric plexus, Paneth cells, and Peyer's patches). Depletion of self-maintaining macrophages resulted in morphological abnormalities in the submucosal vasculature and loss of enteric neurons, leading to vascular leakage, impaired secretion, and reduced intestinal motility. These results provide critical insights in intestinal macrophage heterogeneity and demonstrate the strategic role of self-maintaining macrophages in gut homeostasis and intestinal physiology.},
  author       = {De Schepper, Sebastiaan and Verheijden, Simon and Aguilera-Lizarraga, Javier and Viola, Maria Francesca and Boesmans, Werend and Stakenborg, Nathalie and Voytyuk, Iryna and Smidt, Inga and Boeckx, Bram and Dierckx de Casterle, Isabelle and Baekelandt, Veerle and Gonzalez Dominguez, Erika and Mack, Matthias and Depoortere, Inge and De Strooper, Bart and Sprangers, Ben and Himmelreich, Uwe and Soenen, Stefaan and Guilliams, Martin and Vanden Berghe, Pieter and Jones, Elizabeth and Lambrechts, Diether and Boeckxstaens, Guy},
  issn         = {0092-8674},
  journal      = {CELL},
  keywords     = {TISSUE MACROPHAGES,EXPRESSION PROFILES,ADULT MICROGLIA,PEYERS PATCH,CELL,MONOCYTES,RESPONSES,IDENTITY,REVEALS,ORIGINS},
  language     = {eng},
  number       = {2},
  pages        = {400--415},
  title        = {Self-maintaining gut macrophages are essential for intestinal homeostasis},
  url          = {http://dx.doi.org/10.1016/j.cell.2018.07.048},
  volume       = {175},
  year         = {2018},
}

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