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Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research

Steven Timmermans (UGent) , Jolien Souffriau (UGent) , Jolien Vandewalle (UGent) , Lise Van Wyngene (UGent) , Kelly Van Looveren (UGent) , Tineke Vanderhaeghen (UGent) and Claude Libert (UGent)
(2018) MAMMALIAN GENOME. 29(7-8). p.585-592
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Abstract
Inbred mouse strains derived from the species Mus spretus have been very informative in the study of certain gene polymorphisms in inflammation and infection. Based on our interest in sepsis, we used SPRET/EiJ mice and mapped several critical loci that are linked to sensitivity to cytokine-induced inflammation and endotoxemia. These studies were based on prominent phenotypes that have never been observed in strains derived from Mus musculus and we mapped them at a resolution that enables us to draw conclusions on the mechanisms. Now that the genome of SPRET/EiJ has been sequenced, and other tools have become available, it is time to revisit this strain and emphasize its advantages and disadvantages as a research tool and a discovery platform.
Keywords
TUMOR-NECROSIS-FACTOR, INDUCED LETHAL SHOCK, FACTOR RECEPTOR 1, ANTITUMOR THERAPY, LPS RESISTANCE, MICE, TNF, SEPSIS, GENOME, GENE

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Chicago
Timmermans, Steven, Jolien Souffriau, Jolien Vandewalle, Lise Van Wyngene, Kelly Van Looveren, Tineke Vanderhaeghen, and Claude Libert. 2018. “Using the Inbred Mouse Strain SPRET/EiJ to Provide Novel Insights in Inflammation and Infection Research.” Mammalian Genome 29 (7-8): 585–592.
APA
Timmermans, S., Souffriau, J., Vandewalle, J., Van Wyngene, L., Van Looveren, K., Vanderhaeghen, T., & Libert, C. (2018). Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research. MAMMALIAN GENOME, 29(7-8), 585–592.
Vancouver
1.
Timmermans S, Souffriau J, Vandewalle J, Van Wyngene L, Van Looveren K, Vanderhaeghen T, et al. Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research. MAMMALIAN GENOME. 2018;29(7-8):585–92.
MLA
Timmermans, Steven et al. “Using the Inbred Mouse Strain SPRET/EiJ to Provide Novel Insights in Inflammation and Infection Research.” MAMMALIAN GENOME 29.7-8 (2018): 585–592. Print.
@article{8583002,
  abstract     = {Inbred mouse strains derived from the species Mus spretus have been very informative in the study of certain gene polymorphisms in inflammation and infection. Based on our interest in sepsis, we used SPRET/EiJ mice and mapped several critical loci that are linked to sensitivity to cytokine-induced inflammation and endotoxemia. These studies were based on prominent phenotypes that have never been observed in strains derived from Mus musculus and we mapped them at a resolution that enables us to draw conclusions on the mechanisms. Now that the genome of SPRET/EiJ has been sequenced, and other tools have become available, it is time to revisit this strain and emphasize its advantages and disadvantages as a research tool and a discovery platform.},
  author       = {Timmermans, Steven and Souffriau, Jolien and Vandewalle, Jolien and Van Wyngene, Lise and Van Looveren, Kelly and Vanderhaeghen, Tineke and Libert, Claude},
  issn         = {0938-8990},
  journal      = {MAMMALIAN GENOME},
  language     = {eng},
  number       = {7-8},
  pages        = {585--592},
  title        = {Using the inbred mouse strain SPRET/EiJ to provide novel insights in inflammation and infection research},
  url          = {http://dx.doi.org/10.1007/s00335-018-9751-x},
  volume       = {29},
  year         = {2018},
}

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