@article{8582776,
  abstract     = {{Deep brain stimulation (DBS) of the anterior nucleus of the thalamus (ANT) is a promising treatment for patients with refractory epilepsy. However, therapy response varies and precise positioning of the DBS lead is potentially essential for maximizing therapeutic efficacy. We investigate if single-cell recordings acquired by microelectrode recordings can aid targeting of the ANT during surgery and hypothesize that the neuronal firing properties of the target region relate to clinical outcome. We prospectively included 10 refractory epilepsy patients and performed microelectrode recordings under general anesthesia to identify the change in neuronal signals when approaching and transecting the ANT. The neuronal firing properties of the target region, anatomical locations of microelectrode recordings and active contact positions of the DBS lead along the recorded trajectory were compared between responders and nonresponders to DBS. We obtained 19 sets of recordings from 10 patients (five responders and five nonresponders). Amongst the 403 neurons detected, 365 (90.6%) were classified as bursty. Entry into the ANT was characterized by an increase in firing rate while exit of the ANT was characterized by a decrease in firing rate. Comparing the trajectories of responders to nonresponders, we found differences neither in the neuronal firing properties themselves nor in their locations relative to the position of the active contact. Single-cell firing rate acquired by microelectrode recordings under general anesthesia can thus aid targeting of the ANT during surgery, but is not related to clinical outcome in DBS for patients with refractory epilepsy.}},
  articleno    = {{1850012}},
  author       = {{Schaper, Frédéric LWVJ and Zhao, Yan and Janssen, Marcus LF and Wagner, G Louis and Colon, Albert J and Hilkman, Danny MW and Gommer, Erik and Vlooswijk, Mariëlle CG and Hoogland, Govert and Ackermans, Linda and Bour, Lo J and Van Wezel, Richard JA and Boon, Paul and Temel, Yasin and Heida, Tjitske and Van Kranen-Mastenbroek, Vivianne HJM and Rouhl, Rob PW}},
  issn         = {{0129-0657}},
  journal      = {{INTERNATIONAL JOURNAL OF NEURAL SYSTEMS}},
  keywords     = {{Deep brain stimulation,anterior nucleus of the thalamus,epilepsy,microelectrode recordings,ELECTRICAL-STIMULATION,SUBTHALAMIC NUCLEUS,DBS}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{12}},
  title        = {{Single-cell recordings to target the anterior nucleus of the thalamus in deep brain stimulation for patients with refractory epilepsy}},
  url          = {{http://doi.org/10.1142/s0129065718500120}},
  volume       = {{29}},
  year         = {{2019}},
}

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