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Synchrotron-based phase contrast imaging of cardiovascular tissue in mice-grating interferometry or phase propagation?

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Abstract
Synchrotron-based x-ray phase-contrast imaging allows for detailed 3D insight into the microstructure of soft tissue and is increasingly used to improve our understanding of mouse models of cardiovascular disease. Two techniques dominate the field: grating interferometry, with superior density contrast at mid to lower microscopic resolutions, and propagation-based phase contrast, facilitating high-resolution tissue imaging. The choice between these techniques depends on which features one is interested in visualizing and is thus highly sample-dependent. In this manuscript we systematically evaluate the advantages and disadvantages of grating interferometry and propagation-based phase contrast for the specific application of pre-clinical cardiovascular tissue. We scanned samples obtained from 5 different mouse models of cardiovascular disease, ranging from carotid plaques over ascending and abdominal aortic aneurysms to hypertrophic hearts. Based on our findings we discuss in detail how synchrotron-based imaging can be used to increase our understanding of the anatomy and biomechanics of cardiovascular disease in mice. We also present a flowchart that can help future users to select the best synchrotron-based phase contrast technique for their pre-clinical cardiovascular samples.
Keywords
synchrotron-based x-ray imaging, grating interferometry, phase propagation, mouse models of cardiovascular disease, AORTIC-ANEURYSM, TOMOGRAPHY, RESOLUTION, DISEASE, MODEL, ARCH

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MLA
Trachet, Bram, et al. “Synchrotron-Based Phase Contrast Imaging of Cardiovascular Tissue in Mice-Grating Interferometry or Phase Propagation?” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, vol. 5, no. 1, IOP Publishing, 2019, pp. 1–11, doi:10.1088/2057-1976/aaeb65.
APA
Trachet, B., Lovric, G., Villanueva-Perez, P., Aslanidou, L., Ferraro, M., Logghe, G., … Segers, P. (2019). Synchrotron-based phase contrast imaging of cardiovascular tissue in mice-grating interferometry or phase propagation? BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, 5(1), 1–11. https://doi.org/10.1088/2057-1976/aaeb65
Chicago author-date
Trachet, Bram, Goran Lovric, Pablo Villanueva-Perez, Lydia Aslanidou, Mauro Ferraro, Gerlinde Logghe, Nikolaos Stergiopulos, and Patrick Segers. 2019. “Synchrotron-Based Phase Contrast Imaging of Cardiovascular Tissue in Mice-Grating Interferometry or Phase Propagation?” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 5 (1): 1–11. https://doi.org/10.1088/2057-1976/aaeb65.
Chicago author-date (all authors)
Trachet, Bram, Goran Lovric, Pablo Villanueva-Perez, Lydia Aslanidou, Mauro Ferraro, Gerlinde Logghe, Nikolaos Stergiopulos, and Patrick Segers. 2019. “Synchrotron-Based Phase Contrast Imaging of Cardiovascular Tissue in Mice-Grating Interferometry or Phase Propagation?” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS 5 (1): 1–11. doi:10.1088/2057-1976/aaeb65.
Vancouver
1.
Trachet B, Lovric G, Villanueva-Perez P, Aslanidou L, Ferraro M, Logghe G, et al. Synchrotron-based phase contrast imaging of cardiovascular tissue in mice-grating interferometry or phase propagation? BIOMEDICAL PHYSICS & ENGINEERING EXPRESS. 2019;5(1):1–11.
IEEE
[1]
B. Trachet et al., “Synchrotron-based phase contrast imaging of cardiovascular tissue in mice-grating interferometry or phase propagation?,” BIOMEDICAL PHYSICS & ENGINEERING EXPRESS, vol. 5, no. 1, pp. 1–11, 2019.
@article{8582641,
  abstract     = {Synchrotron-based x-ray phase-contrast imaging allows for detailed 3D insight into the microstructure of soft tissue and is increasingly used to improve our understanding of mouse models of cardiovascular disease. Two techniques dominate the field: grating interferometry, with superior density contrast at mid to lower microscopic resolutions, and propagation-based phase contrast, facilitating high-resolution tissue imaging. The choice between these techniques depends on which features one is interested in visualizing and is thus highly sample-dependent. In this manuscript we systematically evaluate the advantages and disadvantages of grating interferometry and propagation-based phase contrast for the specific application of pre-clinical cardiovascular tissue. We scanned samples obtained from 5 different mouse models of cardiovascular disease, ranging from carotid plaques over ascending and abdominal aortic aneurysms to hypertrophic hearts. Based on our findings we discuss in detail how synchrotron-based imaging can be used to increase our understanding of the anatomy and biomechanics of cardiovascular disease in mice. We also present a flowchart that can help future users to select the best synchrotron-based phase contrast technique for their pre-clinical cardiovascular samples.},
  articleno    = {015010},
  author       = {Trachet, Bram and Lovric, Goran and Villanueva-Perez, Pablo and Aslanidou, Lydia and Ferraro, Mauro and Logghe, Gerlinde and Stergiopulos, Nikolaos and Segers, Patrick},
  issn         = {2057-1976},
  journal      = {BIOMEDICAL PHYSICS & ENGINEERING EXPRESS},
  keywords     = {synchrotron-based x-ray imaging,grating interferometry,phase propagation,mouse models of cardiovascular disease,AORTIC-ANEURYSM,TOMOGRAPHY,RESOLUTION,DISEASE,MODEL,ARCH},
  language     = {eng},
  number       = {1},
  pages        = {015010:1--015010:11},
  publisher    = {IOP Publishing},
  title        = {Synchrotron-based phase contrast imaging of cardiovascular tissue in mice-grating interferometry or phase propagation?},
  url          = {http://dx.doi.org/10.1088/2057-1976/aaeb65},
  volume       = {5},
  year         = {2019},
}

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