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Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer

(2017) NATURE GENETICS. 49(12). p.1767-1778
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Abstract
Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease(1). We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 x 10(-8) with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.
Keywords
GENOME-WIDE ASSOCIATION, BRCA2 MUTATION CARRIERS, SUSCEPTIBILITY LOCI, CONFER SUSCEPTIBILITY, FUNCTIONAL VARIANTS, OVARIAN CANCERS, COMMON VARIANTS, CONSORTIUM, EXPRESSION, DISEASE

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MLA
Milne, Roger L, Karoline B Kuchenbaecker, Kyriaki Michailidou, et al. “Identification of Ten Variants Associated with Risk of Estrogen-receptor-negative Breast Cancer.” NATURE GENETICS 49.12 (2017): 1767–1778. Print.
APA
Milne, R. L., Kuchenbaecker, K. B., Michailidou, K., Beesley, J., Kar, S., Lindström, S., Hui, S., et al. (2017). Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. NATURE GENETICS, 49(12), 1767–1778.
Chicago author-date
Milne, Roger L, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindström, Shirley Hui, et al. 2017. “Identification of Ten Variants Associated with Risk of Estrogen-receptor-negative Breast Cancer.” Nature Genetics 49 (12): 1767–1778.
Chicago author-date (all authors)
Milne, Roger L, Karoline B Kuchenbaecker, Kyriaki Michailidou, Jonathan Beesley, Siddhartha Kar, Sara Lindström, Shirley Hui, Audrey Lemaçon, Penny Soucy, Joe Dennis, Xia Jiang, Asha Rostamianfar, Hilary Finucane, Manjeet K Bolla, Lesley McGuffog, Qin Wang, Cora M Aalfs, Marcia Adams, Julian Adlard, Simona Agata, Shahana Ahmed, Habibul Ahsan, Kristiina Aittomäki, Fares Al-Ejeh, Jamie Allen, Christine B Ambrosone, Christopher I Amos, Irene L Andrulis, Hoda Anton-Culver, Natalia N Antonenkova, Volker Arndt, Norbert Arnold, Kristan J Aronson, Bernd Auber, Paul L Auer, Margreet G E M Ausems, Jacopo Azzollini, François Bacot, Judith Balmaña, Monica Barile, Laure Barjhoux, Rosa B Barkardottir, Myrto Barrdahl, Daniel Barnes, Daniel Barrowdale, Caroline Baynes, Matthias W Beckmann, Javier Benitez, Marina Bermisheva, Leslie Bernstein, Yves-Jean Bignon, Kathleen R Blazer, Marinus J Blok, Carl Blomqvist, William Blot, Kristie Bobolis, Bram Boeckx, Natalia V Bogdanova, Anders Bojesen, Stig E Bojesen, Bernardo Bonanni, Anne-Lise Børresen-Dale, Aniko Bozsik, Angela R Bradbury, Judith S Brand, Hiltrud Brauch, Hermann Brenner, Brigitte Bressac-de Paillerets, Carole Brewer, Louise Brinton, Per Broberg, Angela Brooks-Wilson, Joan Brunet, Thomas Brüning, Barbara Burwinkel, Saundra S Buys, Jinyoung Byun, Qiuyin Cai, Trinidad Caldés, Maria A Caligo, Ian Campbell, Federico Canzian, Olivier Caron, Angel Carracedo, Brian D Carter, J Esteban Castelao, Laurent Castera, Virginie Caux-Moncoutier, Salina B Chan, Jenny Chang-Claude, Stephen J Chanock, Xiaoqing Chen, Ting-Yuan David Cheng, Jocelyne Chiquette, Hans Christiansen, Kathleen Claes, Christine L Clarke, Thomas Conner, Don M Conroy, Jackie Cook, Emilie Cordina-Duverger, Sten Cornelissen, Isabelle Coupier, Angela Cox, David G Cox, Simon S Cross, Katarina Cuk, Julie M Cunningham, Kamila Czene, Mary B Daly, Francesca Damiola, Hatef Darabi, Rosemarie Davidson, Kim De Leeneer, Peter Devilee, Ed Dicks, Orland Diez, Yuan Chun Ding, Nina Ditsch, Kimberly F Doheny, Susan M Domchek, Cecilia M Dorfling, Thilo Dörk, Isabel dos-Santos-Silva, Stéphane Dubois, Pierre-Antoine Dugué, Martine Dumont, Alison M Dunning, Lorraine Durcan, Miriam Dwek, Bernd Dworniczak, Diana Eccles, Ros Eeles, Hans Ehrencrona, Ursula Eilber, Bent Ejlertsen, Arif B Ekici, A Heather Eliassen, Christoph Engel, Mikael Eriksson, Laura Fachal, Laurence Faivre, Peter A Fasching, Ulrike Faust, Jonine Figueroa, Dieter Flesch-Janys, Olivia Fletcher, Henrik Flyger, William D Foulkes, Eitan Friedman, Lin Fritschi, Debra Frost, Marike Gabrielson, Pragna Gaddam, Marilie D Gammon, Patricia A Ganz, Susan M Gapstur, Judy Garber, Vanesa Garcia-Barberan, José A García-Sáenz, Mia M Gaudet, Marion Gauthier-Villars, Andrea Gehrig, Vassilios Georgoulias, Anne-Marie Gerdes, Graham G Giles, Gord Glendon, Andrew K Godwin, Mark S Goldberg, David E Goldgar, Anna González-Neira, Paul Goodfellow, Mark H Greene, Grethe I Grenaker Alnæs, Mervi Grip, Jacek Gronwald, Anne Grundy, Daphne Gschwantler-Kaulich, Pascal Guénel, Qi Guo, Lothar Haeberle, Eric Hahnen, Christopher A Haiman, Niclas Håkansson, Emily Hallberg, Ute Hamann, Nathalie Hamel, Susan Hankinson, Thomas V O Hansen, Patricia Harrington, Steven N Hart, Jaana M Hartikainen, Catherine S Healey, Alexander Hein, Sonja Helbig, Alex Henderson, Jane Heyworth, Belynda Hicks, Peter Hillemanns, Shirley Hodgson, Frans B Hogervorst, Antoinette Hollestelle, Maartje J Hooning, Bob Hoover, John L Hopper, Chunling Hu, Guanmengqian Huang, Peter J Hulick, Keith Humphreys, David J Hunter, Evgeny N Imyanitov, Claudine Isaacs, Motoki Iwasaki, Louise Izatt, Anna Jakubowska, Paul James, Ramunas Janavicius, Wolfgang Janni, Uffe Birk Jensen, Esther M John, Nichola Johnson, Kristine Jones, Michael Jones, Arja Jukkola-Vuorinen, Rudolf Kaaks, Maria Kabisch, Katarzyna Kaczmarek, Daehee Kang, Karin Kast, Renske Keeman, Michael J Kerin, Carolien M Kets, Machteld Keupers, Sofia Khan, Elza Khusnutdinova, Johanna I Kiiski, Sung-Won Kim, Julia A Knight, Irene Konstantopoulou, Veli-Matti Kosma, Vessela N Kristensen, Torben A Kruse, Ava Kwong, Anne-Vibeke Lænkholm, Yael Laitman, Fiona Lalloo, Diether Lambrechts, Keren Landsman, Christine Lasset, Conxi Lazaro, Loic Le Marchand, Julie Lecarpentier, Andrew Lee, Eunjung Lee, Jong Won Lee, Min Hyuk Lee, Flavio Lejbkowicz, Fabienne Lesueur, Jingmei Li, Jenna Lilyquist, Anne Lincoln, Annika Lindblom, Jolanta Lissowska, Wing-Yee Lo, Sibylle Loibl, Jirong Long, Jennifer T Loud, Jan Lubinski, Craig Luccarini, Michael Lush, Robert J MacInnis, Tom Maishman, Enes Makalic, Ivana Maleva Kostovska, Kathleen E Malone, Siranoush Manoukian, JoAnn E Manson, Sara Margolin, John W M Martens, Maria Elena Martinez, Keitaro Matsuo, Dimitrios Mavroudis, Sylvie Mazoyer, Catriona McLean, Hanne Meijers-Heijboer, Primitiva Menéndez, Jeffery Meyer, Hui Miao, Austin Miller, Nicola Miller, Gillian Mitchell, Marco Montagna, Kenneth Muir, Anna Marie Mulligan, Claire Mulot, Sue Nadesan, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Ines Nevelsteen, Dieter Niederacher, Sune F Nielsen, Børge G Nordestgaard, Aaron Norman, Robert L Nussbaum, Edith Olah, Olufunmilayo I Olopade, Janet E Olson, Curtis Olswold, Kai-ren Ong, Jan C Oosterwijk, Nick Orr, Ana Osorio, V Shane Pankratz, Laura Papi, Tjoung-Won Park-Simon, Ylva Paulsson-Karlsson, Rachel Lloyd, Inge Søkilde Pedersen, Bernard Peissel, Ana Peixoto, Jose I A Perez, Paolo Peterlongo, Julian Peto, Georg Pfeiler, Catherine M Phelan, Mila Pinchev, Dijana Plaseska-Karanfilska, Bruce Poppe, Mary E Porteous, Ross Prentice, Nadege Presneau, Darya Prokofieva, Elizabeth Pugh, Miquel Angel Pujana, Katri Pylkäs, Brigitte Rack, Paolo Radice, Nazneen Rahman, Johanna Rantala, Christine Rappaport-Fuerhauser, Gad Rennert, Hedy S Rennert, Valerie Rhenius, Kerstin Rhiem, Andrea Richardson, Gustavo C Rodriguez, Atocha Romero, Jane Romm, Matti A Rookus, Anja Rudolph, Thomas Ruediger, Emmanouil Saloustros, Joyce Sanders, Dale P Sandler, Suleeporn Sangrajrang, Elinor J Sawyer, Daniel F Schmidt, Minouk J Schoemaker, Fredrick Schumacher, Peter Schürmann, Lukas Schwentner, Christopher Scott, Rodney J Scott, Sheila Seal, Leigha Senter, Caroline Seynaeve, Mitul Shah, Priyanka Sharma, Chen-Yang Shen, Xin Sheng, Hermela Shimelis, Martha J Shrubsole, Xiao-Ou Shu, Lucy E Side, Christian F Singer, Christof Sohn, Melissa C Southey, John J Spinelli, Amanda B Spurdle, Christa Stegmaier, Dominique Stoppa-Lyonnet, Grzegorz Sukiennicki, Harald Surowy, Christian Sutter, Anthony Swerdlow, Csilla I Szabo, Rulla M Tamimi, Yen Y Tan, Jack A Taylor, Maria-Isabel Tejada, Maria Tengström, Soo H Teo, Mary B Terry, Daniel C Tessier, Alex Teulé, Kathrin Thöne, Darcy L Thull, Maria Grazia Tibiletti, Laima Tihomirova, Marc Tischkowitz, Amanda E Toland, Rob A E M Tollenaar, Ian Tomlinson, Ling Tong, Diana Torres, Martine Tranchant, Thérèse Truong, Kathy Tucker, Nadine Tung, Jonathan Tyrer, Hans-Ulrich Ulmer, Celine Vachon, Christi J van Asperen, David Van Den Berg, Ans M W van den Ouweland, Elizabeth J van Rensburg, Liliana Varesco, Raymonda Varon-Mateeva, Ana Vega, Alessandra Viel, Joseph Vijai, Daniel Vincent, Jason Vollenweider, Lisa Walker, Zhaoming Wang, Shan Wang-Gohrke, Barbara Wappenschmidt, Clarice R Weinberg, Jeffrey N Weitzel, Camilla Wendt, Jelle Wesseling, Alice S Whittemore, Juul T Wijnen, Walter Willett, Robert Winqvist, Alicja Wolk, Anna H Wu, Lucy Xia, Xiaohong R Yang, Drakoulis Yannoukakos, Daniela Zaffaroni, Wei Zheng, Bin Zhu, Argyrios Ziogas, Elad Ziv, Kristin K Zorn, Manuela Gago-Dominguez, Arto Mannermaa, Håkan Olsson, Manuel R Teixeira, Jennifer Stone, Kenneth Offit, Laura Ottini, Sue K Park, Mads Thomassen, Per Hall, Alfons Meindl, Rita K Schmutzler, Arnaud Droit, Gary D Bader, Paul D P Pharoah, Fergus J Couch, Douglas F Easton, Peter Kraft, Georgia Chenevix-Trench, Montserrat García-Closas, Marjanka K Schmidt, Antonis C Antoniou, and Jacques Simard. 2017. “Identification of Ten Variants Associated with Risk of Estrogen-receptor-negative Breast Cancer.” Nature Genetics 49 (12): 1767–1778.
Vancouver
1.
Milne RL, Kuchenbaecker KB, Michailidou K, Beesley J, Kar S, Lindström S, et al. Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer. NATURE GENETICS. 2017;49(12):1767–78.
IEEE
[1]
R. L. Milne et al., “Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer,” NATURE GENETICS, vol. 49, no. 12, pp. 1767–1778, 2017.
@article{8582495,
  abstract     = {Most common breast cancer susceptibility variants have been identified through genome-wide association studies (GWAS) of predominantly estrogen receptor (ER)-positive disease(1). We conducted a GWAS using 21,468 ER-negative cases and 100,594 controls combined with 18,908 BRCA1 mutation carriers (9,414 with breast cancer), all of European origin. We identified independent associations at P < 5 x 10(-8) with ten variants at nine new loci. At P < 0.05, we replicated associations with 10 of 11 variants previously reported in ER-negative disease or BRCA1 mutation carrier GWAS and observed consistent associations with ER-negative disease for 105 susceptibility variants identified by other studies. These 125 variants explain approximately 16% of the familial risk of this breast cancer subtype. There was high genetic correlation (0.72) between risk of ER-negative breast cancer and breast cancer risk for BRCA1 mutation carriers. These findings may lead to improved risk prediction and inform further fine-mapping and functional work to better understand the biological basis of ER-negative breast cancer.},
  author       = {Milne, Roger L and Kuchenbaecker, Karoline B and Michailidou, Kyriaki and Beesley, Jonathan and Kar, Siddhartha and Lindström, Sara and Hui, Shirley and Lemaçon, Audrey and Soucy, Penny and Dennis, Joe and Jiang, Xia and Rostamianfar, Asha and Finucane, Hilary and Bolla, Manjeet K and McGuffog, Lesley and Wang, Qin and Aalfs, Cora M and Adams, Marcia and Adlard, Julian and Agata, Simona and Ahmed, Shahana and Ahsan, Habibul and Aittomäki, Kristiina and Al-Ejeh, Fares and Allen, Jamie and Ambrosone, Christine B and Amos, Christopher I and Andrulis, Irene L and Anton-Culver, Hoda and Antonenkova, Natalia N and Arndt, Volker and Arnold, Norbert and Aronson, Kristan J and Auber, Bernd and Auer, Paul L and Ausems, Margreet G E M and Azzollini, Jacopo and Bacot, François and Balmaña, Judith and Barile, Monica and Barjhoux, Laure and Barkardottir, Rosa B and Barrdahl, Myrto and Barnes, Daniel and Barrowdale, Daniel and Baynes, Caroline and Beckmann, Matthias W and Benitez, Javier and Bermisheva, Marina and Bernstein, Leslie and Bignon, Yves-Jean and Blazer, Kathleen R and Blok, Marinus J and Blomqvist, Carl and Blot, William and Bobolis, Kristie and Boeckx, Bram and Bogdanova, Natalia V and Bojesen, Anders and Bojesen, Stig E and Bonanni, Bernardo and Børresen-Dale, Anne-Lise and Bozsik, Aniko and Bradbury, Angela R and Brand, Judith S and Brauch, Hiltrud and Brenner, Hermann and Bressac-de Paillerets, Brigitte and Brewer, Carole and Brinton, Louise and Broberg, Per and Brooks-Wilson, Angela and Brunet, Joan and Brüning, Thomas and Burwinkel, Barbara and Buys, Saundra S and Byun, Jinyoung and Cai, Qiuyin and Caldés, Trinidad and Caligo, Maria A and Campbell, Ian and Canzian, Federico and Caron, Olivier and Carracedo, Angel and Carter, Brian D and Castelao, J Esteban and Castera, Laurent and Caux-Moncoutier, Virginie and Chan, Salina B and Chang-Claude, Jenny and Chanock, Stephen J and Chen, Xiaoqing and Cheng, Ting-Yuan David and Chiquette, Jocelyne and Christiansen, Hans and Claes, Kathleen and Clarke, Christine L and Conner, Thomas and Conroy, Don M and Cook, Jackie and Cordina-Duverger, Emilie and Cornelissen, Sten and Coupier, Isabelle and Cox, Angela and Cox, David G and Cross, Simon S and Cuk, Katarina and Cunningham, Julie M and Czene, Kamila and Daly, Mary B and Damiola, Francesca and Darabi, Hatef and Davidson, Rosemarie and De Leeneer, Kim and Devilee, Peter and Dicks, Ed and Diez, Orland and Ding, Yuan Chun and Ditsch, Nina and Doheny, Kimberly F and Domchek, Susan M and Dorfling, Cecilia M and Dörk, Thilo and dos-Santos-Silva, Isabel and Dubois, Stéphane and Dugué, Pierre-Antoine and Dumont, Martine and Dunning, Alison M and Durcan, Lorraine and Dwek, Miriam and Dworniczak, Bernd and Eccles, Diana and Eeles, Ros and Ehrencrona, Hans and Eilber, Ursula and Ejlertsen, Bent and Ekici, Arif B and Eliassen, A Heather and Engel, Christoph and Eriksson, Mikael and Fachal, Laura and Faivre, Laurence and Fasching, Peter A and Faust, Ulrike and Figueroa, Jonine and Flesch-Janys, Dieter and Fletcher, Olivia and Flyger, Henrik and Foulkes, William D and Friedman, Eitan and Fritschi, Lin and Frost, Debra and Gabrielson, Marike and Gaddam, Pragna and Gammon, Marilie D and Ganz, Patricia A and Gapstur, Susan M and Garber, Judy and Garcia-Barberan, Vanesa and García-Sáenz, José A and Gaudet, Mia M and Gauthier-Villars, Marion and Gehrig, Andrea and Georgoulias, Vassilios and Gerdes, Anne-Marie and Giles, Graham G and Glendon, Gord and Godwin, Andrew K and Goldberg, Mark S and Goldgar, David E and González-Neira, Anna and Goodfellow, Paul and Greene, Mark H and Alnæs, Grethe I Grenaker and Grip, Mervi and Gronwald, Jacek and Grundy, Anne and Gschwantler-Kaulich, Daphne and Guénel, Pascal and Guo, Qi and Haeberle, Lothar and Hahnen, Eric and Haiman, Christopher A and Håkansson, Niclas and Hallberg, Emily and Hamann, Ute and Hamel, Nathalie and Hankinson, Susan and Hansen, Thomas V O and Harrington, Patricia and Hart, Steven N and Hartikainen, Jaana M and Healey, Catherine S and Hein, Alexander and Helbig, Sonja and Henderson, Alex and Heyworth, Jane and Hicks, Belynda and Hillemanns, Peter and Hodgson, Shirley and Hogervorst, Frans B and Hollestelle, Antoinette and Hooning, Maartje J and Hoover, Bob and Hopper, John L and Hu, Chunling and Huang, Guanmengqian and Hulick, Peter J and Humphreys, Keith and Hunter, David J and Imyanitov, Evgeny N and Isaacs, Claudine and Iwasaki, Motoki and Izatt, Louise and Jakubowska, Anna and James, Paul and Janavicius, Ramunas and Janni, Wolfgang and Jensen, Uffe Birk and John, Esther M and Johnson, Nichola and Jones, Kristine and Jones, Michael and Jukkola-Vuorinen, Arja and Kaaks, Rudolf and Kabisch, Maria and Kaczmarek, Katarzyna and Kang, Daehee and Kast, Karin and Keeman, Renske and Kerin, Michael J and Kets, Carolien M and Keupers, Machteld and Khan, Sofia and Khusnutdinova, Elza and Kiiski, Johanna I and Kim, Sung-Won and Knight, Julia A and Konstantopoulou, Irene and Kosma, Veli-Matti and Kristensen, Vessela N and Kruse, Torben A and Kwong, Ava and Lænkholm, Anne-Vibeke and Laitman, Yael and Lalloo, Fiona and Lambrechts, Diether and Landsman, Keren and Lasset, Christine and Lazaro, Conxi and Le Marchand, Loic and Lecarpentier, Julie and Lee, Andrew and Lee, Eunjung and Lee, Jong Won and Lee, Min Hyuk and Lejbkowicz, Flavio and Lesueur, Fabienne and Li, Jingmei and Lilyquist, Jenna and Lincoln, Anne and Lindblom, Annika and Lissowska, Jolanta and Lo, Wing-Yee and Loibl, Sibylle and Long, Jirong and Loud, Jennifer T and Lubinski, Jan and Luccarini, Craig and Lush, Michael and MacInnis, Robert J and Maishman, Tom and Makalic, Enes and Kostovska, Ivana Maleva and Malone, Kathleen E and Manoukian, Siranoush and Manson, JoAnn E and Margolin, Sara and Martens, John W M and Martinez, Maria Elena and Matsuo, Keitaro and Mavroudis, Dimitrios and Mazoyer, Sylvie and McLean, Catriona and Meijers-Heijboer, Hanne and Menéndez, Primitiva and Meyer, Jeffery and Miao, Hui and Miller, Austin and Miller, Nicola and Mitchell, Gillian and Montagna, Marco and Muir, Kenneth and Mulligan, Anna Marie and Mulot, Claire and Nadesan, Sue and Nathanson, Katherine L and Neuhausen, Susan L and Nevanlinna, Heli and Nevelsteen, Ines and Niederacher, Dieter and Nielsen, Sune F and Nordestgaard, Børge G and Norman, Aaron and Nussbaum, Robert L and Olah, Edith and Olopade, Olufunmilayo I and Olson, Janet E and Olswold, Curtis and Ong, Kai-ren and Oosterwijk, Jan C and Orr, Nick and Osorio, Ana and Pankratz, V Shane and Papi, Laura and Park-Simon, Tjoung-Won and Paulsson-Karlsson, Ylva and Lloyd, Rachel and Pedersen, Inge Søkilde and Peissel, Bernard and Peixoto, Ana and Perez, Jose I A and Peterlongo, Paolo and Peto, Julian and Pfeiler, Georg and Phelan, Catherine M and Pinchev, Mila and Plaseska-Karanfilska, Dijana and Poppe, Bruce and Porteous, Mary E and Prentice, Ross and Presneau, Nadege and Prokofieva, Darya and Pugh, Elizabeth and Pujana, Miquel Angel and Pylkäs, Katri and Rack, Brigitte and Radice, Paolo and Rahman, Nazneen and Rantala, Johanna and Rappaport-Fuerhauser, Christine and Rennert, Gad and Rennert, Hedy S and Rhenius, Valerie and Rhiem, Kerstin and Richardson, Andrea and Rodriguez, Gustavo C and Romero, Atocha and Romm, Jane and Rookus, Matti A and Rudolph, Anja and Ruediger, Thomas and Saloustros, Emmanouil and Sanders, Joyce and Sandler, Dale P and Sangrajrang, Suleeporn and Sawyer, Elinor J and Schmidt, Daniel F and Schoemaker, Minouk J and Schumacher, Fredrick and Schürmann, Peter and Schwentner, Lukas and Scott, Christopher and Scott, Rodney J and Seal, Sheila and Senter, Leigha and Seynaeve, Caroline and Shah, Mitul and Sharma, Priyanka and Shen, Chen-Yang and Sheng, Xin and Shimelis, Hermela and Shrubsole, Martha J and Shu, Xiao-Ou and Side, Lucy E and Singer, Christian F and Sohn, Christof and Southey, Melissa C and Spinelli, John J and Spurdle, Amanda B and Stegmaier, Christa and Stoppa-Lyonnet, Dominique and Sukiennicki, Grzegorz and Surowy, Harald and Sutter, Christian and Swerdlow, Anthony and Szabo, Csilla I and Tamimi, Rulla M and Tan, Yen Y and Taylor, Jack A and Tejada, Maria-Isabel and Tengström, Maria and Teo, Soo H and Terry, Mary B and Tessier, Daniel C and Teulé, Alex and Thöne, Kathrin and Thull, Darcy L and Tibiletti, Maria Grazia and Tihomirova, Laima and Tischkowitz, Marc and Toland, Amanda E and Tollenaar, Rob A E M and Tomlinson, Ian and Tong, Ling and Torres, Diana and Tranchant, Martine and Truong, Thérèse and Tucker, Kathy and Tung, Nadine and Tyrer, Jonathan and Ulmer, Hans-Ulrich and Vachon, Celine and van Asperen, Christi J and Van Den Berg, David and van den Ouweland, Ans M W and van Rensburg, Elizabeth J and Varesco, Liliana and Varon-Mateeva, Raymonda and Vega, Ana and Viel, Alessandra and Vijai, Joseph and Vincent, Daniel and Vollenweider, Jason and Walker, Lisa and Wang, Zhaoming and Wang-Gohrke, Shan and Wappenschmidt, Barbara and Weinberg, Clarice R and Weitzel, Jeffrey N and Wendt, Camilla and Wesseling, Jelle and Whittemore, Alice S and Wijnen, Juul T and Willett, Walter and Winqvist, Robert and Wolk, Alicja and Wu, Anna H and Xia, Lucy and Yang, Xiaohong R and Yannoukakos, Drakoulis and Zaffaroni, Daniela and Zheng, Wei and Zhu, Bin and Ziogas, Argyrios and Ziv, Elad and Zorn, Kristin K and Gago-Dominguez, Manuela and Mannermaa, Arto and Olsson, Håkan and Teixeira, Manuel R and Stone, Jennifer and Offit, Kenneth and Ottini, Laura and Park, Sue K and Thomassen, Mads and Hall, Per and Meindl, Alfons and Schmutzler, Rita K and Droit, Arnaud and Bader, Gary D and Pharoah, Paul D P and Couch, Fergus J and Easton, Douglas F and Kraft, Peter and Chenevix-Trench, Georgia and García-Closas, Montserrat and Schmidt, Marjanka K and Antoniou, Antonis C and Simard, Jacques},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keywords     = {GENOME-WIDE ASSOCIATION,BRCA2 MUTATION CARRIERS,SUSCEPTIBILITY LOCI,CONFER SUSCEPTIBILITY,FUNCTIONAL VARIANTS,OVARIAN CANCERS,COMMON VARIANTS,CONSORTIUM,EXPRESSION,DISEASE},
  language     = {eng},
  number       = {12},
  pages        = {1767--1778},
  title        = {Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer},
  url          = {http://dx.doi.org/10.1038/ng.3785},
  volume       = {49},
  year         = {2017},
}

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