Advanced search
1 file | 1.24 MB

Reprogramming of basic metabolic pathways in microbial sepsis : therapeutic targets at last?

Lise Van Wyngene (UGent) , Jolien Vandewalle (UGent) and Claude Libert (UGent)
Author
Organization
Abstract
Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.
Keywords
FATTY-ACID OXIDATION, ACTIVATED RECEPTOR-ALPHA, INDUCED TYROSINE, PHOSPHORYLATION, PYRUVATE-DEHYDROGENASE COMPLEX, INTENSIVE INSULIN, THERAPY, TISSUE LIPOPROTEIN-LIPASE, HISTONE DEACETYLASE SIRT6, INNATE, IMMUNE-RESPONSES, NECROSIS-FACTOR-ALPHA, CYTOCHROME-C-OXIDASE, hypoxia, inflammation, interventions, metabolic reprogramming, sepsis

Downloads

  • 3082 18VanWyngene.pdf
    • full text
    • |
    • open access
    • |
    • PDF
    • |
    • 1.24 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Van Wyngene, Lise, Jolien Vandewalle, and Claude Libert. 2018. “Reprogramming of Basic Metabolic Pathways in Microbial Sepsis : Therapeutic Targets at Last?” Embo Molecular Medicine 10 (8).
APA
Van Wyngene, L., Vandewalle, J., & Libert, C. (2018). Reprogramming of basic metabolic pathways in microbial sepsis : therapeutic targets at last? EMBO MOLECULAR MEDICINE, 10(8).
Vancouver
1.
Van Wyngene L, Vandewalle J, Libert C. Reprogramming of basic metabolic pathways in microbial sepsis : therapeutic targets at last? EMBO MOLECULAR MEDICINE. 2018;10(8).
MLA
Van Wyngene, Lise, Jolien Vandewalle, and Claude Libert. “Reprogramming of Basic Metabolic Pathways in Microbial Sepsis : Therapeutic Targets at Last?” EMBO MOLECULAR MEDICINE 10.8 (2018): n. pag. Print.
@article{8582244,
  abstract     = {Sepsis is a highly lethal and urgent unmet medical need. It is the result of a complex interplay of several pathways, including inflammation, immune activation, hypoxia, and metabolic reprogramming. Specifically, the regulation and the impact of the latter have become better understood in which the highly catabolic status during sepsis and its similarity with starvation responses appear to be essential in the poor prognosis in sepsis. It seems logical that new interventions based on the recognition of new therapeutic targets in the key metabolic pathways should be developed and may have a good chance to penetrate to the bedside. In this review, we concentrate on the pathological changes in metabolism, observed during sepsis, and the presumed underlying mechanisms, with a focus on the level of the organism and the interplay between different organ systems.},
  articleno    = {e8712},
  author       = {Van Wyngene, Lise and Vandewalle, Jolien and Libert, Claude},
  issn         = {1757-4676},
  journal      = {EMBO MOLECULAR MEDICINE},
  keywords     = {FATTY-ACID OXIDATION,ACTIVATED RECEPTOR-ALPHA,INDUCED TYROSINE,PHOSPHORYLATION,PYRUVATE-DEHYDROGENASE COMPLEX,INTENSIVE INSULIN,THERAPY,TISSUE LIPOPROTEIN-LIPASE,HISTONE DEACETYLASE SIRT6,INNATE,IMMUNE-RESPONSES,NECROSIS-FACTOR-ALPHA,CYTOCHROME-C-OXIDASE,hypoxia,inflammation,interventions,metabolic reprogramming,sepsis},
  language     = {eng},
  number       = {8},
  pages        = {18},
  title        = {Reprogramming of basic metabolic pathways in microbial sepsis : therapeutic targets at last?},
  url          = {http://dx.doi.org/10.15252/emmm.201708712},
  volume       = {10},
  year         = {2018},
}

Altmetric
View in Altmetric
Web of Science
Times cited: