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Mathematical modelling and simulation of a spray fluidized bed granulator

(2018) PROCESSES. 6(10).
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Abstract
In this present work, a study of the modelling and simulation for a top-sprayed fluidized bed granulator (SFBG) is presented, which is substantially used by the pharmaceutical industry to prepare granules. The idea is to build a number-based mathematical model using the notion of population balances by dividing a top SFBG into two different zones, namely the wet zone and dry zone. To solve a two-compartment model, an existing accurate and efficient finite volume scheme is implemented. In order to validate the compartmental model, a new class of analytical moments is derived corresponding to various combinations of aggregation and breakage kernels. To verify the accuracy of a modified finite volume scheme, the zeroth and first order moments computed using the finite volume scheme are compared with the newly-derived analytical results. Moreover, the stability of the compartmental model and the numerical scheme is tested by varying the size of the wet zone. It is also shown that the relative errors in both order moments increase with the increase in the size of the wet zone.
Keywords
agglomeration, breakage, compartmental modelling, sprayed fluidized bed granulation, population balance equation, finite volume scheme, DISCRETIZED POPULATION BALANCE, AGGREGATION, AGGLOMERATION, FORMULATION, EQUATION, BATCH

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Citation

Please use this url to cite or link to this publication:

MLA
Kaur, Gurmeet, Mehakpreet Singh, Jitendra Kumar, et al. “Mathematical Modelling and Simulation of a Spray Fluidized Bed Granulator.” PROCESSES 6.10 (2018): n. pag. Print.
APA
Kaur, G., Singh, M., Kumar, J., De Beer, T., & Nopens, I. (2018). Mathematical modelling and simulation of a spray fluidized bed granulator. PROCESSES, 6(10).
Chicago author-date
Kaur, Gurmeet, Mehakpreet Singh, Jitendra Kumar, Thomas De Beer, and Ingmar Nopens. 2018. “Mathematical Modelling and Simulation of a Spray Fluidized Bed Granulator.” Processes 6 (10).
Chicago author-date (all authors)
Kaur, Gurmeet, Mehakpreet Singh, Jitendra Kumar, Thomas De Beer, and Ingmar Nopens. 2018. “Mathematical Modelling and Simulation of a Spray Fluidized Bed Granulator.” Processes 6 (10).
Vancouver
1.
Kaur G, Singh M, Kumar J, De Beer T, Nopens I. Mathematical modelling and simulation of a spray fluidized bed granulator. PROCESSES. 2018;6(10).
IEEE
[1]
G. Kaur, M. Singh, J. Kumar, T. De Beer, and I. Nopens, “Mathematical modelling and simulation of a spray fluidized bed granulator,” PROCESSES, vol. 6, no. 10, 2018.
@article{8581870,
  abstract     = {In this present work, a study of the modelling and simulation for a top-sprayed fluidized bed granulator (SFBG) is presented, which is substantially used by the pharmaceutical industry to prepare granules. The idea is to build a number-based mathematical model using the notion of population balances by dividing a top SFBG into two different zones, namely the wet zone and dry zone. To solve a two-compartment model, an existing accurate and efficient finite volume scheme is implemented. In order to validate the compartmental model, a new class of analytical moments is derived corresponding to various combinations of aggregation and breakage kernels. To verify the accuracy of a modified finite volume scheme, the zeroth and first order moments computed using the finite volume scheme are compared with the newly-derived analytical results. Moreover, the stability of the compartmental model and the numerical scheme is tested by varying the size of the wet zone. It is also shown that the relative errors in both order moments increase with the increase in the size of the wet zone.},
  articleno    = {195},
  author       = {Kaur, Gurmeet and Singh, Mehakpreet and Kumar, Jitendra and De Beer, Thomas and Nopens, Ingmar},
  issn         = {2227-9717},
  journal      = {PROCESSES},
  keywords     = {agglomeration,breakage,compartmental modelling,sprayed fluidized bed granulation,population balance equation,finite volume scheme,DISCRETIZED POPULATION BALANCE,AGGREGATION,AGGLOMERATION,FORMULATION,EQUATION,BATCH},
  language     = {eng},
  number       = {10},
  pages        = {13},
  title        = {Mathematical modelling and simulation of a spray fluidized bed granulator},
  url          = {http://dx.doi.org/10.3390/pr6100195},
  volume       = {6},
  year         = {2018},
}

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