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Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation

Kristof Vandekerckhove (UGent) , Kathleen De Waele (UGent) , Aurelie Minne (UGent) , Ilse Coomans (UGent) , Katya De Groote (UGent) , JOSEPH PANZER (UGent) , Catharina Dhooge (UGent) , Maria Bordon Cueto De Braem (UGent) , Daniël De Wolf (UGent) and Jan Boone (UGent)
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Abstract
Background: Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. Procedure: Children underwent cardiopulmonary exercise testing (CPET) at least 1 year after hematopoietic stem cell transplantation (HSCT) and were compared with healthy controls. Systolic and diastolic heart function and left ventricle (LV) wall dimensions were measured. Health-related QOL (HR-QOL) was evaluated using PedsQL questionnaires. Results: Forty-three patients performed CPET (26 boys, 13.6 +/- 3.4 years, weight 45.5 +/- 13.3 kg, length 152.9 +/- 17.5 cm, body surface area 1.35 +/- 0.28). HSCT patients had lower maximal oxygen consumption (VO2peak/kg, 34.7 +/- 8.4 vs 46.3 +/- 7.1 mL/kg/min, P < 0.001), shorter exercise duration (9.1 +/- 2.5 vs 12.9 +/- 2.6 min, P < 0.001), and lower maximal load (%Ppeak 70.8 +/- 19.7 vs 102.4% +/- 15.9%, P < 0.001). Echocardiography demonstrated decreased interventricular septal wall thickness (interventricular septum in diastole [IVSd] Z-value -0.64 +/- 0.69, P < 0.001), and more systolic (11% of patients) and diastolic dysfunction (high E/E' Z-value 1.06 +/- 1.13, P < 0.001). LV dilatation correlates with VO2max/kg (r = -0.364, P = 0.017). HR-QOL showed lower overall and emotional functioning scores (respectively, P = 0.016 and P = 0.001). Patients after anthracycline therapy have the lowest maximal exercise performance, but have no difference in QOL. Diminished exercise performance is not encountered as a QOL limitation. Total body irradiation influences the domain of psychosocial functioning. Conclusions: LV (systolic and diastolic) and right ventricle dysfunctions justify the need for thorough cardiac follow-up in children after HSCT. Lower physical fitness levels and lower HR-QOL emphasize the importance of CPET and fitness programs.
Keywords
cardiac function, exercise performance, hematopoietic stem cell transplantation, quality of life, BONE-MARROW-TRANSPLANTATION, CHILDHOOD-CANCER, PHYSICAL-ACTIVITY, CARDIAC-FUNCTION, YOUNG-ADULTS, SURVIVORS, CARDIOTOXICITY, HEALTH, CAPACITY, HSCT

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MLA
Vandekerckhove, Kristof, et al. “Evaluation of Cardiopulmonary Exercise Testing, Heart Function, and Quality of Life in Children after Allogenic Hematopoietic Stem Cell Transplantation.” PEDIATRIC BLOOD & CANCER, vol. 66, no. 1, 2019, doi:10.1002/pbc.27499.
APA
Vandekerckhove, K., De Waele, K., Minne, A., Coomans, I., De Groote, K., PANZER, J., … Boone, J. (2019). Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation. PEDIATRIC BLOOD & CANCER, 66(1). https://doi.org/10.1002/pbc.27499
Chicago author-date
Vandekerckhove, Kristof, Kathleen De Waele, Aurelie Minne, Ilse Coomans, Katya De Groote, JOSEPH PANZER, Catharina Dhooge, Maria Bordon Cueto De Braem, Daniël De Wolf, and Jan Boone. 2019. “Evaluation of Cardiopulmonary Exercise Testing, Heart Function, and Quality of Life in Children after Allogenic Hematopoietic Stem Cell Transplantation.” PEDIATRIC BLOOD & CANCER 66 (1). https://doi.org/10.1002/pbc.27499.
Chicago author-date (all authors)
Vandekerckhove, Kristof, Kathleen De Waele, Aurelie Minne, Ilse Coomans, Katya De Groote, JOSEPH PANZER, Catharina Dhooge, Maria Bordon Cueto De Braem, Daniël De Wolf, and Jan Boone. 2019. “Evaluation of Cardiopulmonary Exercise Testing, Heart Function, and Quality of Life in Children after Allogenic Hematopoietic Stem Cell Transplantation.” PEDIATRIC BLOOD & CANCER 66 (1). doi:10.1002/pbc.27499.
Vancouver
1.
Vandekerckhove K, De Waele K, Minne A, Coomans I, De Groote K, PANZER J, et al. Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation. PEDIATRIC BLOOD & CANCER. 2019;66(1).
IEEE
[1]
K. Vandekerckhove et al., “Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation,” PEDIATRIC BLOOD & CANCER, vol. 66, no. 1, 2019.
@article{8581755,
  abstract     = {{Background: Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. 
Procedure: Children underwent cardiopulmonary exercise testing (CPET) at least 1 year after hematopoietic stem cell transplantation (HSCT) and were compared with healthy controls. Systolic and diastolic heart function and left ventricle (LV) wall dimensions were measured. Health-related QOL (HR-QOL) was evaluated using PedsQL questionnaires.
Results: Forty-three patients performed CPET (26 boys, 13.6 +/- 3.4 years, weight 45.5 +/- 13.3 kg, length 152.9 +/- 17.5 cm, body surface area 1.35 +/- 0.28). HSCT patients had lower maximal oxygen consumption (VO2peak/kg, 34.7 +/- 8.4 vs 46.3 +/- 7.1 mL/kg/min, P < 0.001), shorter exercise duration (9.1 +/- 2.5 vs 12.9 +/- 2.6 min, P < 0.001), and lower maximal load (%Ppeak 70.8 +/- 19.7 vs 102.4% +/- 15.9%, P < 0.001). Echocardiography demonstrated decreased interventricular septal wall thickness (interventricular septum in diastole [IVSd] Z-value -0.64 +/- 0.69, P < 0.001), and more systolic (11% of patients) and diastolic dysfunction (high E/E' Z-value 1.06 +/- 1.13, P < 0.001). LV dilatation correlates with VO2max/kg (r = -0.364, P = 0.017). HR-QOL showed lower overall and emotional functioning scores (respectively, P = 0.016 and P = 0.001). Patients after anthracycline therapy have the lowest maximal exercise performance, but have no difference in QOL. Diminished exercise performance is not encountered as a QOL limitation. Total body irradiation influences the domain of psychosocial functioning.
Conclusions: LV (systolic and diastolic) and right ventricle dysfunctions justify the need for thorough cardiac follow-up in children after HSCT. Lower physical fitness levels and lower HR-QOL emphasize the importance of CPET and fitness programs.}},
  articleno    = {{e27499}},
  author       = {{Vandekerckhove, Kristof and De Waele, Kathleen and Minne, Aurelie and Coomans, Ilse and De Groote, Katya and PANZER, JOSEPH and Dhooge, Catharina and Bordon Cueto De Braem, Maria and De Wolf, Daniël and Boone, Jan}},
  issn         = {{1545-5009}},
  journal      = {{PEDIATRIC BLOOD & CANCER}},
  keywords     = {{cardiac function,exercise performance,hematopoietic stem cell transplantation,quality of life,BONE-MARROW-TRANSPLANTATION,CHILDHOOD-CANCER,PHYSICAL-ACTIVITY,CARDIAC-FUNCTION,YOUNG-ADULTS,SURVIVORS,CARDIOTOXICITY,HEALTH,CAPACITY,HSCT}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{7}},
  title        = {{Evaluation of cardiopulmonary exercise testing, heart function, and quality of life in children after allogenic hematopoietic stem cell transplantation}},
  url          = {{http://dx.doi.org/10.1002/pbc.27499}},
  volume       = {{66}},
  year         = {{2019}},
}

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